Development of new syntheses and transformations of β-lactones : application to a concise total synthesis of (+)-brefeldin A /

A highly diastereoselective approach to cis-disubstituted β-lactones has been developed and involves a SnCl₄-mediated reaction between aldehydes and thiopyridyl ketene acetals. Results to date are most consistent with a stepwise [2 + 2] cycloaddition. Certain substrates and reaction conditions led...

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Bibliographic Details

Main Author:	Wang, Yingcai, 1972-
Format:	Thesis Book
Language:	English
Published:	[Place of publication not identified] : [publisher not identified] ; 2002.
Subjects:	Major chemistry.
Online Access:	http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=764786551&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD