Mechanisms of estrogen receptor (ER) action in breast cancer cells : role of ER AF-1 domain in ER/SP-1 transactivation and modulation of ER by the RING finger coactivator SNURF /

17β-Estradiol (E2) induces expression of several genes via estrogen receptor (ER)-Sp1 protein interactions with GC-rich promoter elements in which Sp1 but not ER binds DNA. This study reports the ligand- and cell context-dependent ER[α]/Sp1 and ER[β]/Sp1 action using an E2-responsive construct (pSp...

Full description

Bibliographic Details

Main Author:	Saville, Bradley Martin
Format:	Thesis Book
Language:	English
Published:	[Place of publication not identified] : [publisher not identified] ; 2002.
Subjects:	Major biochemistry.
Online Access:	http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=726462311&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD