Synthesis and biological evaluation of a bicyclo[7.4.1]enediyne and enantioselective synthesis of 1,2-Aziridinomitosenes /
Naturally occurring enediyne antibiotics possess fascinating structural features, interesting modes of action, and potent antitumor activities. This novel class of antibiotics includes the neocarzinostatin chromophore, [calicheamicin M1] , [esperamicin A,] , and dynemicin A. These molecules have sti...
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| Format: | Thesis Book |
| Language: | English |
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[Place of publication not identified] :
[publisher not identified] ;
1998.
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| Subjects: | |
| Online Access: | http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=732838441&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD |
| Summary: | Naturally occurring enediyne antibiotics possess fascinating structural features, interesting modes of action, and potent antitumor activities. This novel class of antibiotics includes the neocarzinostatin chromophore, [calicheamicin M1] , [esperamicin A,] , and dynemicin A. These molecules have stimulated synthetic studies in the development of novel mechanism based antitumor agents. This dissertation describes the synthesis of unnatural bicyclo[7.4.l]enediynes. The potent biological activity and novel structure of the mitomycins has long provoked interest in the synthesis of members of long provoked interest in the synthesis of members of differing biological profiles of the enantiomer of mitomycin C, the development of an enantioselective construction of mitomycin ring system is benefical. An enantioselective approach to l,2-aziridinomitosenes based on chemosensitive intramolecular carbon-hydrogen insertion of diazoester is also discussed. In connection with the preparation of the diazoester connection with the preparation of the diazoester substituted phenyl acetic acid derivatives was developed. |
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| Item Description: | Vita. "Major Subject: Chemistry". |
| Physical Description: | xiv, 220 leaves : illustrations ; 28 cm. Issued also on microfiche from University Microfilm Inc. |
| Bibliography: | Includes bibliographical references: pages 93-99. |