Probing the mechanism of transthyretin amyloid fibril formation by site-directed mutagenesis and by in vitro inhibition of amyloid fibril formation /

The mechanism of transthyretin (TTR) amyloid fibril formation was studied by acid-induced denaturation which results in the formation of an intermediate that either undergoes further denaturation or self-assembles into amyloid fibrils. TTR acid denaturation involves a tetramer to monomer transition...

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Bibliographic Details

Main Author:	McCutchen, Sandra Lynn, 1966-
Format:	Thesis Book
Language:	English
Published:	[Place of publication not identified] : [publisher not identified] ; 1995.
Subjects:	Major chemistry.
Online Access:	http://proxy.library.tamu.edu/login?url=http://proquest.umi.com/pqdweb?did=742145291&sid=1&Fmt=2&clientId=2945&RQT=309&VName=PQD