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Table of Contents: “...Absolute bioavailability (ABA) -- Novel study design: duo-tracer for ABA and mass balance in a single-period study -- Conclusions -- References -- 11 -- Conquering low oral bioavailability issues in drug discovery and development -- Introduction -- Characterization of bioavailability -- In vivo approaches -- In vitro approaches -- Solubility and permeability -- First pass metabolism -- Design of molecules for optimizing bioavailability -- Rule-based approaches to design -- Computational modeling -- Formulation strategies to optimize bioavailability -- Conclusion -- References -- 12 -- Case study of OATP1B DDI assessment and challenges in drug discovery and development-real-life examples -- Background -- BMS-919373 -- Estimation of drug interaction potential for BMS-919373 using in vitro data -- Pharmacokinetcs of rosuvastatin and BMS-919373 in cynomolgus monkeys -- (A) BMS-919373 20mg/kg -- (B) BMS-919373 1mg/kg -- Pharmacokinetics of statins and BMS-919373 in human subjects -- Safety -- Discussion -- Conclusion -- References -- 13 -- Investigating the link between drug metabolism and toxicity -- Introduction -- Utility of metabolite-mediated toxicity information in discovery and development -- Discovery studies -- Development studies -- Metabolites in safety testing considerations -- Species specific metabolism-related toxicology -- Metabolism-related toxicology during clinical development -- Methods to investigate metabolite-mediated toxicology -- Exposure at site of action -- In vitro methods -- In vivo methods -- Examples of metabolite-mediated toxicity -- General -- Amgen PI3K inhibitor program -- Bristol-Myers Squibb MET kinase inhibitor -- Saxagliptin -- Empagliflozin -- SGX523 -- Conclusions -- Abbreviations -- References -- 14 -- Overcoming nephrotoxicity in rats: the successful development and registration of the HIV-AIDS drug efavirenz....”
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Table of Contents: “...Some aspects of the epidemiology and economics of important diseases of large ruminants in Indonesia -- Evaluating economic and epidemiologic data from farms involved in disease surveillance in the US -- Process design and economic evaluation for SCP-production from Bagasse -- An economic evaluation of vibriosis vaccination of rainbow trout reared in Swedish brackish water net-pen farms -- Losses from ovine dermatophilosis -- Economic considerations related to infertility in smallholder dairy cattle in Malaysia -- A benefit-cost analysis of the New Zealand sheep measles control programme -- Economic impact of alternative Johne's disease management control strategies - a simulation approach -- A benefit-cost analysis of the program to eradicate an outbreak of anaplasmosis in Canada -- Screw-worm eradication in Mexico -- The eradication of footrot in sheep -- The eradication of serious animal diseases/zoonoses in Cyprus - echinococcosis, brucellosis and anthrax -- Veterinary epidemiology in Thailand -- Comments on the current rinderpest campaign -- Impact of African Swine Fever in Brazil: a retrospective view -- New OIE information reporting system -- The development of an animal disease information system -- A coding system of diagnoses for computerized data base -- Planning for surveillance systems in the new California veterinary diagnostic laboratory -- The use of abattoir condemnation data in a pig herd health programme -- Surveillance for bovine tuberculosis: the efficiency of an abattoir traceback system -- Abattoir data as a source of epidemiological information: a neglected resource -- SNOVET/EPIVET - standardising nomenclature -- Domestic ducks as carriers of influenza A virus --...”

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Table of Contents: “...7.5.1 Constant Topology -- 7.5.2 Varying Topology -- 7.6 Transient Electrical Network Analyzers -- 7.7 Special-Purpose Simulators -- 7.8 Computer Programs -- 7.8.1 PSS TM E Version 30 -- 7.8.2 EMTP -- 7.8.2.1 Inductance -- 7.8.2.2 Capacitance -- 7.8.2.3 Lossless Line -- 7.8.2.4 Nodal Equations -- 7.8.2.5 Frequency Scan Facility -- 7.8.3 ATP -- 7.8.4 PSCAD/EMTDC -- 7.8.5 SuperHarm -- 7.8.5.1 SuperHarm Models -- 7.8.5.2 SuperHarm Solution Procedure -- 7.8.5.3 Support Options -- 7.8.5.4 Pricing and Availability -- 7.8.6 Three-Phase Power Flow Programs -- 7.8.6.1 Powerlink Program -- 7.8.6.2 HARMFLO Program -- 7.9 DADiSP -- 7.10 Conclusions -- References -- Chapter 8 Monitoring Power Quality -- 8.1 Introduction -- 8.2 Site Surveys -- 8.2.1 Spectrum Analyzers -- 8.2.2 Special-Purpose Power System Harmonic Analyzers -- 8.2.3 Transient-Disturbance Analyzers -- 8.2.4 Combination Disturbance and Harmonic Analyzers -- 8.2.5 Flicker Meters -- 8.3 Transducers -- 8.3.1 Measurement of the Frequency Response of Instrument Transformers -- 8.3.2 Description of the Instrument Transformers' Tests -- 8.3.3 Summary of the Conclusions from the Tests -- 8.3.3.1 Voltage Transformers -- 8.4 IEC-Recommended Measurement Techniques for Harmonics -- 8.4.1 Harmonics -- 8.4.1.1 RMS Value of a Harmonic Group: G[Sub(g, n)] -- 8.4.1.2 RMS Value of a Harmonic Subgroup: G[Sub(sg, n)] -- 8.4.2 Total Harmonic Distortion (THD) -- 8.4.2.1 Group Total Harmonic Distortion (THDG) -- 8.4.2.2 Subgroup Total Harmonic Distortion (THDS) -- 8.4.2.3 Partial Weighted Harmonic Distortion (PWHD) -- 8.4.3 Interharmonics -- 8.4.3.1 RMS Value of an Interharmonic Component -- 8.4.3.2 RMS Value of an Interharmonic Group (C[Sub(ig, n)]) -- 8.4.3.3 RMS Value of an Interharmonic-Centered Subgroup (C[Sub(isg, n)]) -- 8.4.4 Relative and Absolute Harmonic Phase Angle Measurement....”
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Table of Contents: “...Kalinowski; Vibration Computations and Nomographs- Daniel Inman; Test Equipment and Measuring Instruments, Terrence W. ...”
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Table of Contents: “...Solar Eagle III Wins Sunrayce 97 -- The Needs for Engineering Design Are Boundless -- Greatest Engineering Achievements of the 20th Century -- Rewards and Opportunities of an Engineering Career -- Job Satisfaction -- Varied Opportunities -- Challenging Work -- Intellectual Development -- Social Impact -- Financial Security -- Prestige -- Professional Environment -- Understanding How Things Work -- Creative Thinking -- Engineering Disciplines -- Electrical Engineering -- Mechanical Engineering -- Civil Engineering -- Computer Engineering -- Chemical Engineering -- Industrial Engineering -- Overview of Other Engineering Disciplines -- Engineering Job Functions -- Analysis -- Design -- Test -- Development -- Sales -- Research -- Management -- Consulting -- Teaching -- Employment Opportunities -- Organization of Industry in the United States Service Sectors -- Manufacturing Subsectors -- Important Fields for the Future -- Advanced Manufacturing Technologies -- Information and Communication Technologies -- Advanced Materials and Processing --Biotechnology -- Civil Infrastructure Systems -- Improved Health Care Delivery -- Advanced Environmental Technologies -- Engineering as a Profession --...”

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