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1341
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1342Published 2024Table of Contents: “...Front Cover -- Microbial Diversity in the Genomic Era: Functional Diversity and Community Analysis -- Microbial Diversity in the Genomic Era: Functional Diversity and Community Analysis -- Copyright -- Contents -- Contributors -- I -- Overview of Microbial Diversity -- 1.1 -- Molecular Tools for Assessing Bacterial Diversity From Natural Environments -- 1.1.1 INTRODUCTION -- 1.1.2 ANALYSIS OF MICROBIAL COMMUNITIES BASED ON CULTURED APPROACHES -- 1.1.3 ANALYSIS OF MICROBIAL COMMUNITIES USING CULTURE-INDEPENDENT APPROACHES -- 1.1.3.1 Extraction of Environmental DNA (eDNA) From a Natural Sample -- 1.1.3.2 Clone Library and Sanger Sequencing -- 1.1.3.3 Terminal Restriction Fragment Length Polymorphism -- 1.1.3.4 Denaturing Gradient Gel Electrophoresis -- 1.1.3.5 Fluorescence In Situ Hybridization -- 1.1.3.6 Next-Generation Sequencing (NGS) -- 1.1.3.6.1 Illumina Sequencing -- 1.1.4 PROCESSING OF NGS DATA -- 1.1.5 THIRD-GENERATION SEQUENCERS -- 1.1.6 "OMICS"-DRIVEN METAGENOMICS -- REFERENCES -- 1.2 -- Importance of Microbial Diversity on Health: Perhaps the Best Tool to Intervene in Emerging and Continuing Di ... -- 1.2.1 BACKGROUND -- 1.2.2 INTRODUCTION -- 1.2.2.1 Gut Microbiota -- 1.2.2.2 Gut Microbial Composition, Host Immunity, and Metabolism -- 1.2.3 GUT MICROBIAL COMPOSITION (ABUNDANCE AND DIVERSITY) AND THEIR IMPORTANCE AND RELATION TO DISEASES -- 1.2.4 MOLECULAR BASIS OF MICROBIOME DISEASE CORRELATION: IN THE PERSPECTIVE OF CONSERVED AND UNIQUENESS OF METAGENOME AND METABOL ... -- 1.2.4.1 Neurological Diseases -- 1.2.4.2 Cardiovascular Diseases -- 1.2.4.3 Oncogenic Diseases -- 1.2.4.4 Gastrointestinal Diseases -- 1.2.4.5 Metabolic Diseases -- 1.2.4.6 Respiratory Diseases -- 1.2.5 IMPLICATION FROM THE PERSPECTIVE OF GUT MICROBIOTA -- 1.2.6 PROSPECTIVE -- AUTHOR CONTRIBUTIONS -- CONFLICT OF INTEREST -- APPENDIX -- Acknowledgments -- REFERENCES....”
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1343
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1344
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1345Published 2023Table of Contents: “...Front Cover -- Overcoming Obstacles in Drug Discovery and Development -- Overcoming Obstacles in Drug Discovery and Development -- Copyright -- Contents -- Contributors -- Preface -- 1 -- Learning to think critically -- Some concerns with drug development & -- discovery -- Critical thinking basics -- Critical thinking analysis -- Critical thinking assessment -- Critical thinking traits -- Working on critical thinking -- Biases and conclusion -- References -- 2 -- Leveraging ADME/PK information to enable knowledge-driven decisions in drug discovery and development -- Introduction -- Decision-making stages across the drug discovery/development continuum -- The importance of data in decision-making -- Product differentiation: first in class versus best in class -- Developing and using a target product profile in decision-making -- Why drugs fail and the evolution of ADME/PK in drug discovery -- Conclusion -- References -- 3 -- Systems biology and data science in research and translational medicine -- Brief overview of scope of systems biology and applications -- Introduction -- The origin of systems biology hypothesis -- Systems biology-the approach and scope -- Systems biology and its applications -- Obstacles in drug discovery and translational medicine, with a focus on new indications/targets-systems biology as a bridge ... -- Systems biology as the integration of discovery biology and data sciences -- Quantitative Systems Pharmacology Models-mechanistic virtualization of drug discovery and development processes -- Defining the therapeutics mechanism of action -- Systems biology and pharmacology approaches in translational medicine -- Three illustrative examples -- Rare diseases-development of gene therapies -- Global Public Health-challenges specific to public health and opportunities captured versus gaps....”
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