Published 2023
Table of Contents:
“...Front Cover -- Overcoming Obstacles in Drug Discovery and Development -- Overcoming Obstacles in Drug Discovery and Development -- Copyright -- Contents -- Contributors -- Preface -- 1 -- Learning to think critically -- Some concerns with drug development & -- discovery -- Critical thinking basics -- Critical thinking analysis -- Critical thinking assessment -- Critical thinking traits -- Working on critical thinking -- Biases and conclusion -- References -- 2 -- Leveraging ADME/PK information to enable knowledge-driven decisions in drug discovery and development -- Introduction -- Decision-making stages across the drug discovery/development continuum -- The importance of data in decision-making -- Product differentiation: first in class versus
best in class -- Developing and using a target product profile in decision-making -- Why drugs fail and the evolution of ADME/PK in drug discovery -- Conclusion -- References -- 3 -- Systems biology and data science in research and translational medicine -- Brief overview of scope of systems biology and applications -- Introduction -- The origin of systems biology hypothesis -- Systems biology-the approach and scope -- Systems biology and its applications -- Obstacles in drug discovery and translational medicine, with a focus on new indications/targets-systems biology as a bridge ... -- Systems biology as the integration of discovery biology and data sciences -- Quantitative Systems Pharmacology Models-mechanistic virtualization of drug discovery and development
processes -- Defining the therapeutics mechanism of action -- Systems biology and pharmacology approaches in translational medicine -- Three illustrative examples -- Rare diseases-development of gene therapies -- Global Public Health-challenges specific to public health and opportunities captured versus gaps....
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