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3941
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3942by Guedes Soares, CarlosTable of Contents: “...Front Cover -- Table of contents -- Preface -- Organisation -- Sponsors -- Invited lectures -- The past, present and future of the ocean engineering activities -- Risk assessment for ship collisions against offshore structures -- Ports -- The container terminal characteristics and customer satisfaction -- Performance evaluation using data envelopment analysis: The case of Portuguese general cargo terminals -- A System Dynamics model for evaluating container terminal management policies -- Methodology and tools to design container terminals -- Maritime transportation -- A generic maritime transportation network model -- Assessment of motorways of the sea through a method based on analysis of decision groups -- Competition dynamics between the Hamburg-Le Havre and the Mediterranean port ranges -- Inland navigation -- Technical feasibility study of iron ore export using Douro river -- Analysis of river/sea transportation of ore bulk using simulation process -- Design optimization of a bulk carrier for river/sea ore transport -- Forecasting navigability conditions of the Tapajós waterway-Amazon-Brazil -- Maritime economy -- Features of the maritime clusters of the Atlantic Arc -- Participative approaches to the Portuguese maritime cluster -- Multipliers, linkages and influence fields among the sectors of the Portuguese maritime cluster -- Main challenges facing the aquaculture sector: From a worldwide insight to a regional perspective -- Ship traffic -- The FCM classification of the ARPA targets -- Simulation and analysis of maritime traffic in the Tagus River Estuary using AIS data -- Assessment of ship collision estimation methods using AIS data -- Ship emergency response workflow modeling based on WIFA in uncertain knowledge of situation -- Maritime accidents....”
Published 2014
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3943Published 2023Table of Contents: “...Absolute bioavailability (ABA) -- Novel study design: duo-tracer for ABA and mass balance in a single-period study -- Conclusions -- References -- 11 -- Conquering low oral bioavailability issues in drug discovery and development -- Introduction -- Characterization of bioavailability -- In vivo approaches -- In vitro approaches -- Solubility and permeability -- First pass metabolism -- Design of molecules for optimizing bioavailability -- Rule-based approaches to design -- Computational modeling -- Formulation strategies to optimize bioavailability -- Conclusion -- References -- 12 -- Case study of OATP1B DDI assessment and challenges in drug discovery and development-real-life examples -- Background -- BMS-919373 -- Estimation of drug interaction potential for BMS-919373 using in vitro data -- Pharmacokinetcs of rosuvastatin and BMS-919373 in cynomolgus monkeys -- (A) BMS-919373 20mg/kg -- (B) BMS-919373 1mg/kg -- Pharmacokinetics of statins and BMS-919373 in human subjects -- Safety -- Discussion -- Conclusion -- References -- 13 -- Investigating the link between drug metabolism and toxicity -- Introduction -- Utility of metabolite-mediated toxicity information in discovery and development -- Discovery studies -- Development studies -- Metabolites in safety testing considerations -- Species specific metabolism-related toxicology -- Metabolism-related toxicology during clinical development -- Methods to investigate metabolite-mediated toxicology -- Exposure at site of action -- In vitro methods -- In vivo methods -- Examples of metabolite-mediated toxicity -- General -- Amgen PI3K inhibitor program -- Bristol-Myers Squibb MET kinase inhibitor -- Saxagliptin -- Empagliflozin -- SGX523 -- Conclusions -- Abbreviations -- References -- 14 -- Overcoming nephrotoxicity in rats: the successful development and registration of the HIV-AIDS drug efavirenz....”
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3944
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3945
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3948
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3949
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3950Published 2024Table of Contents: “...Data-driven approaches -- 8.5. Decision-making based on PHM -- 8.5.1. ...”
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3951
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