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|a Animal Models of Disease Part B
|c volume editor, Lorenzo Galluzzi, Fernando Aranda Vega, Aitziber Buque Martinez, Jose Manuel Bravo-San Pedro.
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| 264 |
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1 |
|a Amsterdam :
|b Academic Press,
|c 2024.
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|a 1 online resource
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|a Methods in cell biology
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|a Intro -- Animal Models of Disease -- Part B -- Copyright -- Contents -- Contributors -- Animal models of disease: Achievements and challenges -- Acknowledgments -- Competing interests -- References -- Chapter One: Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation -- 1. Introduction -- 2. Methods and strategies to generate C. elegans neurodegenerative models -- 3. Methods and strategies to validate C. elegans neurodegenerative models -- 3.1. C. elegans lifetime cycle synchronization -- 3.1.1. Purpose -- 3.1.2. Materials -- 3.1.3. Methods -- 3.2. Survival assay -- 3.2.1. Purpose -- 3.2.2. Materials -- 3.2.3. Methods -- 3.2.4. Application of survival assays to validate neurodegenerative models -- 3.3. Fertility assay -- 3.3.1. Purpose -- 3.3.2. Materials -- 3.3.3. Methods -- 3.3.4. Application of fertility assays to validate neurodegenerative models -- 3.4. Mobility assay -- 3.4.1. Purpose -- 3.4.2. Materials -- 3.4.3. Methods -- 3.4.4. Video Analysis with Fiji-ImageJ software -- 3.4.5. Application of mobility assays to validate neurodegenerative models -- 3.5. Electropharyngeogram assays -- 3.5.1. Purpose -- 3.5.2. Materials -- 3.5.3. Methods -- 3.5.4. Application of electropharyngeogram assays to validate neurodegenerative models -- 3.6. Confocal imaging -- 3.6.1. Purpose -- 3.6.2. Materials -- 3.6.3. Methods -- 3.6.4. Application of mitochondria confocal imaging assays to validate neurodegenerative models -- 3.7. C. elegans RNA extraction for qRT-PCR and RT-PCR -- 3.7.1. Purpose -- 3.7.2. Materials (see Note 13) -- 3.7.3. Methods -- 3.7.4. Application of qRT-PCR and RT-PCR to validate neurodegenerative models -- 3.8. Defecation rate measurements -- 3.8.1. Purpose -- 3.8.2. Materials -- 3.8.3. Methods -- 3.8.4. Application of rate of defecation measurement assays to validate the neurodegenerative models.
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| 505 |
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|a 4. Discussion -- 5. Notes -- References -- Chapter Two: Animal model of multiple sclerosis: Experimental autoimmune encephalomyelitis -- 1. Introduction -- 2. Models for multiple sclerosis -- 2.1. Virus-induced chronic demyelinating disease -- 2.2. Toxin-induced demyelination -- 2.3. Experimental autoimmune encephalomyelitis -- 3. Spontaneous experimental autoimmune encephalomyelitis -- 4. Induced experimental autoimmune encephalomyelitis -- 5. EAE animal model -- 5.1. Primates -- 5.2. Rodents -- 6. EAE model: Advances in multiple sclerosis -- 6.1. Immune and inflammatory response -- 6.2. Oxidative stress -- 6.3. The role of the microbiota -- 6.4. Therapies and vaccines -- 7. In vitro models -- 8. Conclusions -- References -- Chapter Three: A new procedure to induce aortic aneurysms in mice -- 1. Introduction -- 2. Materials -- 2.1. Fungible material and reagents -- 2.2. Softwares and equipments -- 3. Experimental procedure -- 3.1. Tamoxifen administration -- 3.2. Genotyping -- 3.3. Angiotensin II infusion -- 3.4. Aortic ultrasound in vivo imaging -- 4. Conclusions remark -- 5. Notes -- Acknowledgments -- References -- Chapter Four: Spinal nerve ligation: An experimental model to study neuropathic pain in rats and mice -- 1. Introduction -- 2. Materials -- 2.1. Animals -- 2.2. Drugs -- 2.3. Supplies and equipment -- 3. Methods: Surgical procedure -- 3.1. Rats -- 3.2. Mice -- 3.3. After the nerve ligation in rats and mice -- 4. Nociceptive behavior tests -- 4.1. Evoked stimulus nociceptive behavior -- 4.1.1. Tactile allodynia -- 4.1.2. Muscle hyperalgesia -- 4.1.3. Hargreaves test -- 4.2. Spontaneous nociceptive behavior in neuropathic animals -- 5. Results -- 5.1. Spinal nerve ligation induces evoked stimulus nociceptive behaviors in rats and mice -- 5.2. Spinal nerve ligation induces non-evoked stimulus nociceptive behavior in rats and mice.
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| 520 |
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|a This volume, part of the 'Methods in Cell Biology' series, focuses on animal models of disease, providing a comprehensive overview of methodologies used in research to simulate human diseases in animals. Edited by experts from various institutions, the book explores topics such as the use of C. elegans for disease modeling, experimental autoimmune models for multiple sclerosis, and procedures to induce conditions like aortic aneurysms and neuropathic pain in mice. It serves as a detailed resource for researchers and practitioners in the field of biomedical research, offering insights into the challenges and advancements of using animal models to study diseases and test potential treatments. The book is intended for scientists, researchers, and students involved in biomedical and disease research.
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| 650 |
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|a Animal models in research.
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| 650 |
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|a Pathology, Experimental.
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| 655 |
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7 |
|a Electronic books.
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|a ScienceDirect (Online service)
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|a Methods in cell biology ;
|v v. 197.
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| 856 |
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|a Texas A&M University
|b College Station
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|h Library of Congress classification
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| 998 |
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