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Advances in Parasitology.

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Unveiling the Proteolytic Networks of Parasites, Volume 129 in the Advances in Parasitology series, presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms.

Bibliographic Details
Main Author: Cantacessi, Cinzia
Corporate Author: ScienceDirect (Online service)
Other Authors: Cinzia Cantacessi
Format: eBook
Language:English
Published: Chantilly : Elsevier Science & Technology, 2025.
Edition:1st ed.
Series:Advances in Parasitology Series.
Subjects:
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • 6.1 Model systems for Ascaris
  • 6.2 Ascaris virome
  • 7 Conclusion
  • References
  • Chapter Two: Genetically modified helminths as pharmaceutical biofactories
  • 1 Introduction
  • 1.1 The hygiene hypothesis and the rise of autoimmune diseases
  • 1.2 Helminth infections and immunoregulation
  • 1.2.1 Controlled helminth infection in participants with autoimmune diseases
  • 1.2.2 Controlled helminth infection in non-gastrointestinal disease
  • 1.2.3 Helminths control host inflammation via their excretory/secretory products
  • 2 Genetic modification with CRISPR
  • 2.1 Class II, type II-A CRISPR-Cas9 system mechanism of action
  • 2.1.1 Ribonucleoprotein complex targets dsDNA
  • 2.1.1.1 Non-homologous end joining
  • 2.1.1.2 Homology-directed repair in the presence of dsDNA repair templates
  • 3 Genomic modifications of helminths
  • 3.1 Knock-out with Cas9
  • confirmation of genetic modification at the target site
  • 3.1.1 Non-homologous end joining
  • 3.1.2 HDR in the presence of single-stranded oligodeoxynucleotides
  • 3.2 CRISPR-Cas9 and gene knock-in in helminths
  • 3.2.1 Somatic cell transgenesis
  • 3.2.2 Germline cell transgenesis
  • 4 The "therapeutic helminth" pipeline
  • 4.1 The ideal model helminth
  • 4.1.1 Animal helminth models to simulate transgenic helminth infection
  • 4.1.1.1 Nippostrongylus brasiliensis
  • the rat nematode
  • 4.1.1.2 Heligmosomoides polygyrus
  • the mouse nematode
  • 4.1.1.3 Schistosoma miracidia
  • 4.2 Diseases that could benefit from helminth therapy
  • 4.2.1 Inflammatory bowel disease and rheumatoid arthritis
  • 4.2.2 Type II diabetes
  • 4.2.3 Microdosing of therapeutic proteins in coeliac disease and food allergy
  • 4.3 The pinnacle test: Humans
  • 5 Conclusions
  • References
  • Chapter Three: Epithelial cytokines in soil-transmitted helminth infections
  • 1 Introduction to the type 2 immune response.