http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Unveiling the Proteolytic Networks of Parasites, Volume 129 in the Advances in Parasitology series, presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms.
6.1 Model systems for Ascaris -- 6.2 Ascaris virome -- 7 Conclusion -- References -- Chapter Two: Genetically modified helminths as pharmaceutical biofactories -- 1 Introduction -- 1.1 The hygiene hypothesis and the rise of autoimmune diseases -- 1.2 Helminth infections and immunoregulation -- 1.2.1 Controlled helminth infection in participants with autoimmune diseases -- 1.2.2 Controlled helminth infection in non-gastrointestinal disease -- 1.2.3 Helminths control host inflammation via their excretory/secretory products -- 2 Genetic modification with CRISPR -- 2.1 Class II, type II-A CRISPR-Cas9 system mechanism of action -- 2.1.1 Ribonucleoprotein complex targets dsDNA -- 2.1.1.1 Non-homologous end joining -- 2.1.1.2 Homology-directed repair in the presence of dsDNA repair templates -- 3 Genomic modifications of helminths -- 3.1 Knock-out with Cas9 -- confirmation of genetic modification at the target site -- 3.1.1 Non-homologous end joining -- 3.1.2 HDR in the presence of single-stranded oligodeoxynucleotides -- 3.2 CRISPR-Cas9 and gene knock-in in helminths -- 3.2.1 Somatic cell transgenesis -- 3.2.2 Germline cell transgenesis -- 4 The "therapeutic helminth" pipeline -- 4.1 The ideal model helminth -- 4.1.1 Animal helminth models to simulate transgenic helminth infection -- 4.1.1.1 Nippostrongylus brasiliensis -- the rat nematode -- 4.1.1.2 Heligmosomoides polygyrus -- the mouse nematode -- 4.1.1.3 Schistosoma miracidia -- 4.2 Diseases that could benefit from helminth therapy -- 4.2.1 Inflammatory bowel disease and rheumatoid arthritis -- 4.2.2 Type II diabetes -- 4.2.3 Microdosing of therapeutic proteins in coeliac disease and food allergy -- 4.3 The pinnacle test: Humans -- 5 Conclusions -- References -- Chapter Three: Epithelial cytokines in soil-transmitted helminth infections -- 1 Introduction to the type 2 immune response.