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Advances in Parasitology.

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Unveiling the Proteolytic Networks of Parasites, Volume 130 in the Advances in Parasitology series, presents a cutting-edge exploration of specific proteases across a spectrum of parasitic organisms.

Bibliographic Details
Main Author: Cantacessi, Cinzia
Corporate Author: ScienceDirect (Online service)
Other Authors: Cinzia Cantacessi
Format: eBook
Language:English
Published: Chantilly : Elsevier Science & Technology, 2025.
Edition:1st ed.
Series:Advances in Parasitology Series.
Subjects:
Leishmaniasis.
Parasitology.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Series Page
  • Advances in Parasitology
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Survival of the fittest: How Leishmania evades drug therapy
  • 1 Introduction
  • 2 Treatment failure and clinical relapse
  • 2.1 Treatment failure in human leishmaniasis
  • 2.1.1 Visceral leishmaniasis
  • 2.1.2 Cutaneous leishmaniasis
  • 2.2 Treatment failure in canine leishmaniasis
  • 3 Drug resistance in Leishmania
  • 3.1 Leishmania genome: Organization, genome plasticity, epigenetics, and polymorphism
  • 3.1.1 Pentavalent antimony
  • 3.1.2 Miltefosine
  • 3.1.3 Amphotericin B
  • 3.1.4 Paromomycin
  • 3.1.5 Pentamidine
  • 3.2 Drugs in development and resistance mechanisms
  • 3.3 Extracellular vesicles and drug resistance
  • 4 Therapy amp
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  • perspectives
  • 4.1 Vaccines
  • 4.2 Alternative therapies
  • 4.2.1 Cutaneous and mucocutaneous leishmaniasis
  • 4.2.2 Visceral leishmaniasis
  • 4.3 Host factors amp
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  • protection
  • 4.3.1 Immune response
  • 4.3.2 Co-morbidities
  • 5 Canine leishmaniasis
  • 6 Conclusion amp
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  • perspectives
  • References
  • Chapter Two: Key discoveries from research in anisakiasis: From parasite biology to pathology in the human host
  • 1 Epidemiology of anisakidosis
  • 2 The third- and fourth larval stages
  • 3 Anisakis antigenic properties and host immune response
  • 3.1 Source, structure and allergenicity of Anisakis antigens
  • 3.2 Structural properties
  • 3.3 Thermal stability
  • 3.4 Protease stability
  • 3.5 Routes and time of exposure to Anisakis antigens
  • 3.5.1 Infection by live or dead larvae (Anisakidosis)
  • 3.5.2 Occupational exposure
  • 3.5.3 Duration of antigen exposure
  • 4 Focus on the excreted/secreted milieu.
  • 4.1 The role of the Anisakis L3 secretome in pathology and parasite defence strategy
  • 4.2 Proteomic variability and key immunomodulatory proteins in Anisakis L3 EVs
  • 4.3 RNAi related proteins and miRNAs in Anisakis L3 EVs
  • 5 Learning from in vivo and in vitro models
  • 5.1 The whole larva
  • 5.2 The crude extract
  • 5.3 Excretory/secretory products
  • 6 Clinical cases and long-term effects of Anisakis infections
  • Acknowledgements
  • References
  • Further reading
  • Chapter Three: Hard to make and hard to take: Exploring the current and future barriers to the development and implementation of antipoverty vaccines in sub-Saharan Africa
  • 1 Introduction
  • 2 Antipoverty and antiparasitic vaccines
  • 3 Hard to make
  • 3.1 Scientific challenges for development of antipoverty vaccines
  • 3.2 Financial challenges for the antipoverty vaccines
  • 4 Hard to take
  • 4.1 Implementation challenges for the antipoverty vaccines
  • 4.2 Anti-vaccine conspiracies
  • 4.3 Antipoverty vaccine safety challenges
  • the case of Dengvaxia
  • 5 Antipoverty vaccines
  • stakeholder perceptions (Box 1)
  • 6 Conclusions
  • Acknowledgements
  • References
  • Back Cover.