Cover Image

Nanofiber therapeutics : revolutionizing cancer and inflammation management /

Nanofiber Therapeutics: Revolutionizing Cancer and Inflammation Management is a comprehensive resource designed to enrich knowledge, catalyze scientific advancements, empower patients, and inform policy decisions in nanomedicine. This book leverages the transformative potential of nanotechnology to...

Full description

Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Mishra, Neeraj (Editor), Rath, Goutam (Editor), Singh, Arun Kumar (Editor)
Format: eBook
Language:English
Published: [Place of publication not identified] : Academic Press, 2025.
Subjects:
Cancer > Treatment > Technological innovations.
Nanomedicine.
Inflammation.
Anti-inflammatory agents.
Nanofibers > Therapeutic use.
Nanomedicine
Inflammation
Anti-Inflammatory Agents
Nanomédecine.
Inflammation (Pathologie)
Antiinflammatoires.
Nanofibres > Emploi en thérapeutique.
Cancer > Treatment
Nanofibers
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Nanofiber Therapeutics
  • Nanofiber Therapeutics: Revolutionizing Cancer and Inflammation Management
  • Copyright
  • Contents
  • Contributors
  • About the editors
  • Preface
  • 1
  • Nanofibers: Principles, technology, and current applications in cancer and inflammatory diseases
  • 1. Introduction
  • 1.1 Electrospinning and fabrication of nanofibers
  • 1.1.1 Principle of electrospinning
  • 1.1.2 Electrospinning parameters
  • 1.1.2.1 Operating parameters
  • 1.1.2.2 Solution properties
  • 1.1.2.3 Solvent properties
  • 1.1.2.4 Environmental factors
  • 1.1.3 Types of electrospinning
  • 1.1.3.1 Co-axial electrospinning
  • 1.1.3.2 Emulsion electrospinning
  • 1.1.3.3 Blend electrospinning
  • 1.1.3.4 Side-by-side electrospinning
  • 1.1.3.5 Triaxial electrospinning
  • 1.1.3.6 Melt electrospinning
  • 1.1.3.7 Roller electrospinning
  • 1.1.4 Miscellaneous fabrication techniques
  • 1.1.4.1 Self-assembly
  • 1.1.4.2 Template synthesis
  • 1.1.4.3 Phase separation
  • 1.1.4.4 Drawing
  • 1.1.4.5 Freeze-drying method
  • 1.2 Application of nanofibers in cancer
  • 1.2.1 Breast cancer
  • 1.2.2 Lung cancer
  • 1.2.3 Skin cancer
  • 1.2.4 Prostate cancers
  • 1.2.5 Brain cancer
  • 1.2.6 Liver cancers
  • 1.2.7 Innovative use of electrospun nanofibers in the study of cancer
  • 1.2.7.1 Single and multidrug delivery
  • 1.2.7.2 Cancer cell detection and biosensing
  • 1.2.7.3 Engineering 3D cancer model in-vitro
  • 1.2.7.4 Electrospun scaffolds in conjunction with PTT effect
  • 1.2.7.5 Stimuli-responsive electrospun nanofibers
  • 1.3 Application of nanofibers in inflammatory diseases
  • 1.3.1 Wound healing
  • 1.3.2 Tissue engineering in autoimmune and degenerative disorders
  • 1.3.3 Nonsteroidal antiinflammatory drug delivery systems
  • 1.4 Challenges and solutions
  • 1.5 Conclusions
  • Acknowledgment
  • Declaration
  • References.
  • 2
  • Nanofiber-based drug delivery systems for cancer treatment
  • 1. Introduction to nanofibers in cancer therapy
  • 1.1 Fabrication techniques for nanofibers
  • 1.1.1 Electrospinning: principles and applications
  • 1.1.2 Self-assembly and phase separation methods
  • 1.1.3 Advances in 3D printing for nanofiber production
  • 1.1.3.1 3D printing of thermally conductive polymer composites
  • 1.1.3.2 3D printing of electromagnetic interference shielding polymer composites
  • 1.1.3.3 3D printing of biomedical polymer composites
  • 1.1.3.4 3D printing of self-healing polymer composites
  • 1.1.3.5 3D printing of responsive polymer composites
  • 1.2 Physicochemical properties of nanofibers
  • 1.2.1 Nanofiber morphology
  • 1.2.2 Physical properties of electrospun nanofibers
  • 1.2.3 Geometrical characterization
  • 1.2.4 Chemical characterization
  • 1.2.5 Physical characterization
  • 1.2.6 Mechanical characterization
  • 1.2.7 Surface area, porosity, and mechanical strength
  • 1.2.8 Crystal structure and chemical composition
  • 1.2.9 Mechanical properties
  • 1.2.10 In vitro release and ex vivo cell line studies
  • 1.3 Drug loading and release mechanisms
  • 1.3.1 Drug loading
  • 1.3.2 Drug release
  • 1.4 Controlled and stimuli-responsive release systems
  • 1.4.1 pH-responsive nanofibers
  • 1.4.2 Thermo-responsive nanofibers
  • 1.5 Applications in cancer therapy
  • 1.6 Nanofiber-based platforms for advanced therapies
  • 1.6.1 Nanofibers for immunotherapy
  • 1.6.2 Delivery of gene and RNA-based therapies
  • 1.7 Preclinical and clinical insights
  • 1.8 Emerging trends and future directions
  • 1.9 Challenges and opportunities in scaling up production
  • 1.10 Conclusion
  • References
  • 3
  • Biodegradable polymeric nanofiber-mediated drug delivery approach for localized cancer chemotherapy
  • 1. Introduction.
  • 2. Application of biodegradable polymeric nanofibers in localized cancer chemotherapy
  • 2.1 Biodegradable natural polymeric nanofibers
  • 2.2 Alginate-based nanofibers
  • 2.3 Chitosan-based nanofibers
  • 2.4 Collagen-based nanofibers
  • 2.5 Hyaluronic acid-based nanofibers
  • 2.6 Biodegradable synthetic polymeric nanofibers
  • 2.7 Poly (lactic acid) (PLA)-based nanofiber
  • 2.8 Poly (lactic-co-glycolic acid)-based nanofiber
  • 2.9 Polycaprolactone (PCL)-based nanofiber
  • 2.10 Poly(vinyl alcohol)-based nanofiber
  • 2.11 Combination therapeutics using biodegradable nanofibers
  • 2.12 Chemotherapy and photothermal therapy using nanofibers
  • 2.13 Chemotherapy and magnetic hyperthermia using nanofibers
  • 2.14 Chemotherapy and gene therapy using nanofibers
  • 3. Challenges and conclusion
  • Declaration of competing interest
  • Acknowledgments
  • References
  • 4
  • Stimuli-responsive implantable biodegradable nanofibers for cancer therapy: challenges and opportunities
  • 1. Introduction
  • 2. Tumor microenvironment
  • 3. Stimuli-responsive nanofibers
  • 4. pH-responsive nanofibers
  • 5. ROS-responsive nanofibers
  • 6. Temperature-responsive nanofibers
  • 7. Enzyme-responsive nanofibers
  • 8. Multiple stimuli-responsive nanofibers
  • 9. Fabrication of implantable nanofibers
  • 9.1 Methods of fabrication
  • 10. Biodegradable materials used for fabrication
  • 11. Characterizations methods
  • 12. Challenges in developing implantable nanofibers
  • 13. Biocompatibility
  • 14. Immune response and inflammation
  • 15. Cytotoxicity of degradation products
  • 16. Hemocompatibility and tissue integration
  • 17. Stability
  • 18. Mechanical stability
  • 19. Hydrolytic and enzymatic degradation
  • 20. Storage and shelf-life
  • 21. Drug loading
  • 22. Limited drug encapsulation efficiency
  • 23. Drug-polymer compatibility
  • 24. Maintaining drug activity.
  • 25. Drug release
  • 26. Burst release and initial drug loss
  • 27. Sustained and controlled release
  • 28. Tumor microenvironment
  • 29. Multidrug release systems
  • 30. Opportunities in cancer treatment
  • 31. Enhanced drug delivery and sustained release
  • 32. Combination therapy for synergistic effects
  • 33. Regenerative and postsurgical applications
  • 34. Future perspectives and clinical translation
  • 35. Conclusion
  • AI disclosure
  • References
  • 5
  • Opportunity and challenges in nanofiber technology to target stem and immunocompetent cells for cancer treatment
  • 1. Introduction
  • 1.1 Overview of nanofiber technology
  • 1.2 Significance in cancer treatment
  • 2. Nanofiber technology: fundamentals and key properties
  • 2.1 Structural and functional characteristics
  • 2.1.1 High surface area to volume ratio
  • 2.1.2 Porosity and interconnectivity
  • 2.1.3 Tunable mechanical properties
  • 2.1.4 Biocompatibility and biodegradability
  • 2.1.5 Surface functionalization
  • 2.1.6 Role in mimicking the extracellular matrix
  • 2.2 Topographical features
  • 2.2.1 Bioactive molecule incorporation
  • 2.2.2 Mechanical cues
  • 2.2.3 Promoting stem cell functionality
  • 3. Targeting stem cells using nanofibers
  • 3.1 Stem cells in cancer therapy
  • 3.2 Cancer stem cells (CSCS)
  • 3.3 Therapeutic use of stem cells
  • 3.4 Nanofiber-based delivery systems for stem cells
  • 3.4.1 Microenvironment mimicry
  • 3.4.2 Controlled drug release
  • 3.4.3 Targeted delivery
  • 3.4.4 Integration with immunotherapy
  • 4. Nanofibers and immunocompetent cells
  • 4.1 Modulating immune responses in cancer
  • 4.1.1 Enhancement of antigen presentation
  • 4.1.2 Recruitment of immune cells
  • 4.2 Modulation of tumor microenvironment
  • 4.3 Role of nanofibers in immunotherapy
  • 4.3.1 Delivery of immunotherapeutic agents
  • 4.3.2 Combination therapies.
  • 4.3.3 Protection of therapeutics
  • 4.4 Personalized immunotherapy
  • 5. Challenges in nanofiber technology for cancer treatment
  • 5.1 Biocompatibility and safety concerns
  • 5.1.1 Material selection
  • 5.1.2 Potential for inflammatory response
  • 5.1.3 Long-term stability
  • 5.2 Production and scalability issues
  • 5.2.1 Manufacturing Processes
  • 5.2.2 Cost-Effectiveness
  • 5.2.3 Quality control
  • 5.3 Tumor Microenvironment Interactions
  • 5.3.1 Heterogeneity of tumor microenvironment
  • 5.3.2 Interactions with tumor cells
  • 5.3.3 Potential for immune evasion
  • 6. Emerging opportunities and innovations
  • 6.1 Nanofiber Integration with gene therapy
  • 6.1.1 Enhanced gene delivery
  • 6.1.2 Targeted delivery
  • 6.1.3 Protection of genetic material
  • 6.2 CRISPR and nanotechnology synergies
  • 6.2.1 CRISPR delivery systems
  • 6.2.2 Reduced immunogenicity
  • 6.2.3 Improved editing precision
  • 6.3 Personalized and precision medicine
  • 6.3.1 Customization of therapeutics
  • 6.3.2 Biomarker-driven therapies
  • 6.3.3 Real-time monitoring
  • 7. Clinical translation and future perspectives
  • 7.1 Preclinical and clinical studies
  • 7.1.1 Preclinical studies
  • 7.1.2 Clinical studies
  • 7.1.3 Clinical outcomes
  • 7.2 Regulatory and ethical considerations
  • 7.2.1 Regulatory considerations
  • 7.2.2 Ethical considerations
  • 8. Conclusion
  • 8.1 Summary of opportunities and challenges
  • 8.1.1 Opportunities
  • 8.1.1.1 Targeted delivery systems
  • 8.1.1.2 Integration with advanced therapeutic modalities
  • 8.1.1.3 Customizability and versatility
  • 8.1.1.4 Regenerative medicine applications
  • 8.1.2 Challenges
  • 8.1.2.1 Biocompatibility and safety concerns
  • 8.1.2.2 Production and scalability issues
  • 8.1.2.3 Regulatory and ethical considerations
  • 8.2 Vision for future applications
  • 8.2.1 Next-generation therapeutics.