Advances in Heterocyclic Chemistry.

Advances in Heterocyclic Chemistry, Volume 147 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Bibliographic Details
Main Author:	Scriven, Eric F. V.
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Ramsden, Christopher A.
Format:	eBook
Language:	English
Published:	Chantilly : Elsevier Science & Technology, 2025.
Edition:	1st ed.
Series:	Advances in Heterocyclic Chemistry Series.
Subjects:	Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

2.1.1 Pyrroles
2.1.2 Furans
2.1.3 Thiophenes
2.1.4 Indoles
2.1.5 Carbazoles
2.2 Six-membered heterocycles with one heteroatom
2.2.1 Pyridines
2.2.2 Quinolines
2.2.3 Isoquinolines
2.2.4 Pyrans
2.2.5 Chromene derivatives
2.2.6 Isoflavones
2.3 Five-membered heterocycles with two heteroatoms
2.3.1 Pyrazoles
2.3.2 Isoxazoles
2.3.3 Thiazoles
2.4 Six-membered heterocycles with two heteroatoms
2.4.1 Pyrimidines
2.4.2 Quinazolines
2.4.3 Perimidines
2.4.4 Quinoxalins
2.4.5 Pyridazines
2.4.6 Imidazo[1,2-a]pyridines
2.4.7 Benzimidazoles and benzothiazoles
2.5 Heterocycles with three or more heteroatoms
2.5.1 Triazoles
2.5.2 Oxadiazoles
2.5.3 Triazolo-pyridazines
2.5.4 Pyrazolopyrimidines
2.5.5 Oxazepanes
2.5.6 Sulfonimides
2.6 Spiro-heterocycles
3 Mechanochemical derivatization/functionalization of heterocycles
3.1 C-C bond formation
3.1.1 Alkylation
3.1.2 Alkenylation
3.1.3 Alkynylation
3.1.4 Arylation
3.1.5 Miscellaneous C-C bond formation
3.2 C-X Bond Formation
3.2.1 Trifluoromethylation
3.2.2 Acylation
3.2.3 Diketone formation
3.2.4 Amidation
3.2.5 Borylation
3.2.6 Chalcogenization
3.2.7 Xanthate formation
3.3 Miscellaneous heterocyclic derivatization
3.3.1 N-H activation by Buchwald-Hartwig amination
4 Synthesis of functional heterocycles by mechanochemical methods
4.1 Active pharmaceutical ingredients
4.1.1 Dye and fluorophores
4.1.2 Porphyrins
4.1.3 Covalent-organic framework
5 Summary and future perspective
Acknowledgements
References
Further reading
Chapter Four: Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
1 4'-O-Methylgrynullarin and its derivatives.
2 Synthesis of isoflavone derivatives and their evaluation
3 Divergent total synthesis of 4'-O-methylgrynullarin and its derivatives
4 Scanderone and its derivatives
5 Divergent total synthesis of scanderone and its derivatives
6 Potential of scanderone and its derivatives as therapeutic agents for TTR amyloidosis
7 Synthesis of other natural products from phloroglucinol: Synthesis of bethuphenone F
8 Conclusion
References
Chapter Five: New trends in the synthesis of azulene-fused heterocycles
1 Introduction
2 Synthesis of heterocycles fused to the five-membered ring of azulene
2.1 Heterocycles fused to azulene via its 1,2-positions
2.1.1 Azuleno[1,2-b]thiophene
2.1.2 1H-Azuleno[2,1-b]pyrrole
2.1.3 Azuleno[1,2-d][1,3]dithiole
2.1.4 Azuleno[1,2-c]pyran
2.1.5 1H-azuleno[2,1-c]pyran
2.1.6 1H-azuleno[1,2-c]pyrane
2.1.7 4H-Azuleno[2,1-b]pyran
2.1.8 Azuleno[1,2-c]pyridine
2.1.9 Azuleno[2,1-c]pyridine
2.1.10 Azuleno[2,1-c]pyridazines
2.1.11 Azuleno[2,1-d]pyrimidine
2.1.12 Azuleno-1,4-dithin
2.1.13 1H-Azuleno[1,2-f]isoindole
2.1.14 5H-azuleno[1,2-b]indole
2.1.15 Thiophene[3',4':6,5]pyrido[3,2-a]azulene
2.1.16 Azuleno[1,2-b]thieno[2,3-d]pyridine
2.1.17 1H-Azuleno[2,1-b]pyrazolo[4,3-e]pyridine
2.1.18 Azuleno[2,1-b]quinoline
2.1.19 Azuleno[1,2-c]isoquinoline
2.1.20 Azuleno[2,1-c]benzo[e][1,2]azaborinine
2.1.21 Azuleno[1,2-h][1,6]naphthyridine
2.1.22 Azuleno[1,2-4,5]pyrrolo[2,1-b]quinazoline
2.1.23 Azuleno[1,2-c]azuleno[2',1':5,6]pyrido[3,4-g]isoquinoline
2.2 Heterocycles fused to azulene via its 1,3-positions
2.2.1 Azuliporphyrins
2.3 Heterocycles fused to azulene via its 1,2,3-positions
2.3.1 Azulene-fused azacoronene
2.4 Heterocycles fused to 2,2'- biazulene via their 1,1'-positions
2.4.1 Dicyclohepta[2,3:6,7]-as-indaceno[4,5-b]benzofuran.
2.5 Heterocycles fused to 1,1'- biazulene via their 2,2'-positions
2.5.1 Diazuleno[2',1':5,6
1'',2'':7,8]naphtho[1,2,3,4-lmn]dicyclohepta[1,2:7,8]-as-indaceno[4,5-f][3,8]phenanthroline
2.6 Heterocycles fused to 2,2'- biazulene via their 1,1'- and 3,3'-positions
2.6.1 Diazadiazuleno[1,2,3-ef:1',2',3'-kl]heptalene
3 Synthesis of heterocycles fused to the six-membered ring of azulene
3.1 Heterocycles fused to azulene via its 5,6-positions
3.1.1 1H-azuleno[6,5-c]pyran
3.1.2 Azuleno[5',6':5,6]benzo[2,1-b:3,4-b']dithiophene
3.1.3 5H-Azuleno[5',6':3,4]cyclobuta[1,2-d]dibenzo[b,f]silepine
4 Synthesis of heterocycles fused to both the five- and six-membered ring of azulene
4.1 Heterocycles fused to azulene via its 1,8-positions
4.1.1 2H-Azuleno[8,1-bc]furane
4.1.2 1H-Azuleno[8,1-bc]pyridine
4.1.3 3H-Azuleno[8,1-cd]pyridazine
4.1.4 Cyclopenta[5,6]heptaleno[2,3-c]pyrrole
4.1.5 Azulene-fused porphyrins
5 Conclusion
References
Chapter Six: Recent advances in the synthesis of seven-membered heterocycles by multicomponent and domino reactions (from 2017 to 2024)
1 Introduction
2 Azepines
3 1,3-Diazepines
4 1,4-Diazepines
5 1,5-Diazepines
5.1 Bicyclic 1,5-diazepines (involving 1,2-diaminobenzene and linear ketones or diketones)
5.2 Tricyclic 1,5-diazepines (involving o-diaminobenzenes and cyclic diketones)
5.3 Spirodiazepines
6 Triazepines
6.1 1,3-Oxazepines
6.2 1,4-Oxazepines
6.3 1,5-Oxazepines
6.4 1,4-Thiazepines
6.5 1,5-Thiazepine
7 1,3,5-Oxathiazepine
8 Conclusion
Acknowledgment
References
Index
Back Cover.