http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
This academic volume examines the role of mitochondria in neurotoxicity, exploring their involvement in environmental and metabolic stress-induced neurological disorders. Contributors analyze mitochondrial dysfunction as both a consequence and driver of neurotoxicity, focusing on mechanisms such as oxidative stress, electron transport chain inhibition, and disruptions in mitochondrial dynamics. The book provides insights into the impact of neurotoxic agents, including pesticides, heavy metals, and solvents, on mitochondrial bioenergetics and proteostasis. It also addresses emerging technologies like high-resolution respirometry and mitochondrial proteomics used to study these phenomena. Intended for researchers, clinicians, and students, this work aims to advance understanding of the mitochondrial role in neurodegenerative diseases such as Parkinson's and the gut-brain axis's link to inflammation caused by mitochondrial toxicants.
Preface -- Introduction to mitochondrial toxicity : form, function, and signaling -- Respirometry parameters as indicators of neurotoxicity -- Pesticide exposure and hippocampal neurogenesis : role of ER stress and mitochondrial dysfunction -- Mitochondrial dysfunction induced by trichloroethylene in Parkinson's disease -- Gut-brain axis and inflammation induced by environmental mitochondrial toxicants -- Mitochondrial toxicants to model Parkinson's disease.