http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Metabolites as signals in immunity and inflammation
Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology.
Front Cover -- Metabolites as Signals in Immunity and Inflammation -- Copyright Page -- Contents -- List of contributors -- 1 The metabolism revolution: you need energy to fight and to live -- References -- 2 Host-microbe interactions in the lung and the role of immunometabolism -- Introduction -- Immunometabolites in the infected airway -- Pulmonary immunometabolites and the pathogenesis of bacterial infection -- Succinate -- Pseudomonas aeruginosa infection is fueled by succinate in the lung -- Itaconate -- Pseudomonas aeruginosa forms biofilms in response to itaconate -- The Pseudomonas aeruginosa transcription factor RpoN responds to immunometabolites -- Staphylococcus aureus adapts to airway immunometabolites -- Glucose utilization, proline, and glycolysis by Staphylococcus aureus in vivo -- Itaconate and Staphylococcus aureus clearance by neutrophils -- Itaconate and Staphylococcus aureus biofilm production -- Klebsiella pneumoniae pathotypes direct the immunometabolic response in the lung -- Production of host antiinflammatory metabolites is stimulated by Klebsiella pneumoniae -- Klebsiella pneumoniae responds to immunometabolic pressure through the type 6 secretion system -- Conclusions -- Acknowledgments -- Disclosures -- References -- 3 Crosstalk between metabolites and myeloid cell biology -- Chapter introduction-metabolites: friend or foe? -- Metabolic and innate immune signaling -- mTORC1 -- MAPK -- SREBP -- Stress responses in myeloid cells -- Crosstalk between tissue microenvironment and tissue-resident macrophage metabolism -- Metabolic and functional specialization of macrophages during homeostasis -- Tissue fuels as drivers of inflammation -- Concluding thoughts -- References -- 4 Immunometabolism in macrophage cell death -- Introduction -- Macrophag -- e programmed cell death -- Ferroptosis.
Pentose phosphate pathway -- Amino acid metabolites -- Arginine metabolism in immune cells -- Tryptophan metabolism and the kynurenine pathway -- Glutamine -- Homocysteine -- Tricarboxylic acid cycle intermediates -- Succinate -- Itaconate -- Short-chain fatty acids -- Butyrate and propionate -- Conclusion -- AI disclosure -- References -- 7 Damage-associated molecular patterns as metabolic regulators of innate immunity -- Introduction -- Intracellular metabolites function as damage-associated molecular patterns intrinsically modulating pathogen-associated molecular patterns-induced responses -- Succinate -- Fumarate -- Itaconate -- Metabolites and their derivatives: contrasting results in the context of type I interferons -- An ever-expanding array of immunomodulatory metabolites -- Extracellular damage-associated molecular patterns as extrinsic regulators of pathogen-associated molecular pattern-initiated immunometabolism: the case of oxidized phospholipids -- oxPLs modulate early metabolic reprogramming and block antiinflammatory responses -- oxPLs modulate long-term metabolic processes and boost inflammatory responses -- oxPLs induce hyperinflammation -- Conclusion -- References -- 8 Adaptive immunity and metabolism -- Introduction -- Metabolism of the antigen-presenting cells -- Metabolism of CD8+ T cells -- Naïve T cell metabolism -- T cell activation -- Mitochondrial metabolism dynamics in T cell activation -- Fatty-acid metabolism in activated T cells -- Amino acid metabolism in activated T cells -- Effector and memory CD8+ T cells -- T cell exhaustion -- Metabolism of CD4+ T cells -- Metabolism of CD4+ Treg cells -- Targeting Treg metabolism -- Metabolism of CD4+ Th1 T cells -- Targeting Th1 metabolism -- Metabolism of CD4+ Th2 cells -- Targeting Th2 metabolism -- Metabolism of CD4+ Th9 T cells -- Metabolism of CD4+ Th17 T cells.
"Sailing under false colors": LepR+ SPCs secrete IL-33 to mask the redox immunogenic niche they ensheathe -- Is the sympathetic perineurial cell barrier a mediator of immune privilege? -- References -- 12 Clinical stage drugs utilizing cellular metabolism pathways -- Introduction -- Metabolites as clinical biomarkers -- Targeting-and manipulating-immunometabolism for clinical therapies -- Drugs modulating glycolysis -- Targeting mitochondrial biology -- Targeting the tricarboxylic acid cycle -- Metabolism as a portal to new therapeutics -- Acknowledgments -- References -- Index -- Back Cover.
edited by Tristram A.J. Ryan, Luke A.J. O'Neill and Zbigniew Zaslona.