rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Metabolites as signals in immunity and inflammation
  name:
    name part: Ryan, Tristram A. J.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    place:
      place term: London
    publisher: Academic Press
    date issued: 2025
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology.
  table of contents: Front Cover -- Metabolites as Signals in Immunity and Inflammation -- Copyright Page -- Contents -- List of contributors -- 1 The metabolism revolution: you need energy to fight and to live -- References -- 2 Host-microbe interactions in the lung and the role of immunometabolism -- Introduction -- Immunometabolites in the infected airway -- Pulmonary immunometabolites and the pathogenesis of bacterial infection -- Succinate -- Pseudomonas aeruginosa infection is fueled by succinate in the lung -- Itaconate -- Pseudomonas aeruginosa forms biofilms in response to itaconate -- The Pseudomonas aeruginosa transcription factor RpoN responds to immunometabolites -- Staphylococcus aureus adapts to airway immunometabolites -- Glucose utilization, proline, and glycolysis by Staphylococcus aureus in vivo -- Itaconate and Staphylococcus aureus clearance by neutrophils -- Itaconate and Staphylococcus aureus biofilm production -- Klebsiella pneumoniae pathotypes direct the immunometabolic response in the lung -- Production of host antiinflammatory metabolites is stimulated by Klebsiella pneumoniae -- Klebsiella pneumoniae responds to immunometabolic pressure through the type 6 secretion system -- Conclusions -- Acknowledgments -- Disclosures -- References -- 3 Crosstalk between metabolites and myeloid cell biology -- Chapter introduction-metabolites: friend or foe? -- Metabolic and innate immune signaling -- mTORC1 -- MAPK -- SREBP -- Stress responses in myeloid cells -- Crosstalk between tissue microenvironment and tissue-resident macrophage metabolism -- Metabolic and functional specialization of macrophages during homeostasis -- Tissue fuels as drivers of inflammation -- Concluding thoughts -- References -- 4 Immunometabolism in macrophage cell death -- Introduction -- Macrophag -- e programmed cell death -- Ferroptosis.
  table of contents: Pentose phosphate pathway -- Amino acid metabolites -- Arginine metabolism in immune cells -- Tryptophan metabolism and the kynurenine pathway -- Glutamine -- Homocysteine -- Tricarboxylic acid cycle intermediates -- Succinate -- Itaconate -- Short-chain fatty acids -- Butyrate and propionate -- Conclusion -- AI disclosure -- References -- 7 Damage-associated molecular patterns as metabolic regulators of innate immunity -- Introduction -- Intracellular metabolites function as damage-associated molecular patterns intrinsically modulating pathogen-associated molecular patterns-induced responses -- Succinate -- Fumarate -- Itaconate -- Metabolites and their derivatives: contrasting results in the context of type I interferons -- An ever-expanding array of immunomodulatory metabolites -- Extracellular damage-associated molecular patterns as extrinsic regulators of pathogen-associated molecular pattern-initiated immunometabolism: the case of oxidized phospholipids -- oxPLs modulate early metabolic reprogramming and block antiinflammatory responses -- oxPLs modulate long-term metabolic processes and boost inflammatory responses -- oxPLs induce hyperinflammation -- Conclusion -- References -- 8 Adaptive immunity and metabolism -- Introduction -- Metabolism of the antigen-presenting cells -- Metabolism of CD8+ T cells -- Naïve T cell metabolism -- T cell activation -- Mitochondrial metabolism dynamics in T cell activation -- Fatty-acid metabolism in activated T cells -- Amino acid metabolism in activated T cells -- Effector and memory CD8+ T cells -- T cell exhaustion -- Metabolism of CD4+ T cells -- Metabolism of CD4+ Treg cells -- Targeting Treg metabolism -- Metabolism of CD4+ Th1 T cells -- Targeting Th1 metabolism -- Metabolism of CD4+ Th2 cells -- Targeting Th2 metabolism -- Metabolism of CD4+ Th9 T cells -- Metabolism of CD4+ Th17 T cells.
  table of contents: "Sailing under false colors": LepR+ SPCs secrete IL-33 to mask the redox immunogenic niche they ensheathe -- Is the sympathetic perineurial cell barrier a mediator of immune privilege? -- References -- 12 Clinical stage drugs utilizing cellular metabolism pathways -- Introduction -- Metabolites as clinical biomarkers -- Targeting-and manipulating-immunometabolism for clinical therapies -- Drugs modulating glycolysis -- Targeting mitochondrial biology -- Targeting the tricarboxylic acid cycle -- Metabolism as a portal to new therapeutics -- Acknowledgments -- References -- Index -- Back Cover.
  note: edited by Tristram A.J. Ryan, Luke A.J. O'Neill and Zbigniew Zaslona.
  subject:
    topic: Metabolites
  subject:
    topic: Immunology
  subject:
    topic: Métabolites
  classification: QP171
  classification: 572/.4
  related item:
    identifier: (OCoLC)1381443037
  identifier: 9780443154485
  identifier: 0443154481
  identifier: 9780443154478
  identifier: 0443154473
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: YDX
    record creation date: 250403
    record change date: 20260327190322.5
    record identifier: in00005774752
    language of cataloging:
      language term: eng