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|a 9780443154485
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|z 9780443154478
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|z 0443154473
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|2 23/eng/20250410
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|a TXAM
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| 245 |
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|a Metabolites as signals in immunity and inflammation
|c edited by Tristram A.J. Ryan, Luke A.J. O'Neill and Zbigniew Zaslona.
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| 260 |
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|a London :
|b Academic Press,
|c 2025.
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| 300 |
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|a 1 online resource
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|a Front Cover -- Metabolites as Signals in Immunity and Inflammation -- Copyright Page -- Contents -- List of contributors -- 1 The metabolism revolution: you need energy to fight and to live -- References -- 2 Host-microbe interactions in the lung and the role of immunometabolism -- Introduction -- Immunometabolites in the infected airway -- Pulmonary immunometabolites and the pathogenesis of bacterial infection -- Succinate -- Pseudomonas aeruginosa infection is fueled by succinate in the lung -- Itaconate -- Pseudomonas aeruginosa forms biofilms in response to itaconate -- The Pseudomonas aeruginosa transcription factor RpoN responds to immunometabolites -- Staphylococcus aureus adapts to airway immunometabolites -- Glucose utilization, proline, and glycolysis by Staphylococcus aureus in vivo -- Itaconate and Staphylococcus aureus clearance by neutrophils -- Itaconate and Staphylococcus aureus biofilm production -- Klebsiella pneumoniae pathotypes direct the immunometabolic response in the lung -- Production of host antiinflammatory metabolites is stimulated by Klebsiella pneumoniae -- Klebsiella pneumoniae responds to immunometabolic pressure through the type 6 secretion system -- Conclusions -- Acknowledgments -- Disclosures -- References -- 3 Crosstalk between metabolites and myeloid cell biology -- Chapter introduction-metabolites: friend or foe? -- Metabolic and innate immune signaling -- mTORC1 -- MAPK -- SREBP -- Stress responses in myeloid cells -- Crosstalk between tissue microenvironment and tissue-resident macrophage metabolism -- Metabolic and functional specialization of macrophages during homeostasis -- Tissue fuels as drivers of inflammation -- Concluding thoughts -- References -- 4 Immunometabolism in macrophage cell death -- Introduction -- Macrophag -- e programmed cell death -- Ferroptosis.
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| 505 |
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|a Pentose phosphate pathway -- Amino acid metabolites -- Arginine metabolism in immune cells -- Tryptophan metabolism and the kynurenine pathway -- Glutamine -- Homocysteine -- Tricarboxylic acid cycle intermediates -- Succinate -- Itaconate -- Short-chain fatty acids -- Butyrate and propionate -- Conclusion -- AI disclosure -- References -- 7 Damage-associated molecular patterns as metabolic regulators of innate immunity -- Introduction -- Intracellular metabolites function as damage-associated molecular patterns intrinsically modulating pathogen-associated molecular patterns-induced responses -- Succinate -- Fumarate -- Itaconate -- Metabolites and their derivatives: contrasting results in the context of type I interferons -- An ever-expanding array of immunomodulatory metabolites -- Extracellular damage-associated molecular patterns as extrinsic regulators of pathogen-associated molecular pattern-initiated immunometabolism: the case of oxidized phospholipids -- oxPLs modulate early metabolic reprogramming and block antiinflammatory responses -- oxPLs modulate long-term metabolic processes and boost inflammatory responses -- oxPLs induce hyperinflammation -- Conclusion -- References -- 8 Adaptive immunity and metabolism -- Introduction -- Metabolism of the antigen-presenting cells -- Metabolism of CD8+ T cells -- Naïve T cell metabolism -- T cell activation -- Mitochondrial metabolism dynamics in T cell activation -- Fatty-acid metabolism in activated T cells -- Amino acid metabolism in activated T cells -- Effector and memory CD8+ T cells -- T cell exhaustion -- Metabolism of CD4+ T cells -- Metabolism of CD4+ Treg cells -- Targeting Treg metabolism -- Metabolism of CD4+ Th1 T cells -- Targeting Th1 metabolism -- Metabolism of CD4+ Th2 cells -- Targeting Th2 metabolism -- Metabolism of CD4+ Th9 T cells -- Metabolism of CD4+ Th17 T cells.
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| 505 |
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|a "Sailing under false colors": LepR+ SPCs secrete IL-33 to mask the redox immunogenic niche they ensheathe -- Is the sympathetic perineurial cell barrier a mediator of immune privilege? -- References -- 12 Clinical stage drugs utilizing cellular metabolism pathways -- Introduction -- Metabolites as clinical biomarkers -- Targeting-and manipulating-immunometabolism for clinical therapies -- Drugs modulating glycolysis -- Targeting mitochondrial biology -- Targeting the tricarboxylic acid cycle -- Metabolism as a portal to new therapeutics -- Acknowledgments -- References -- Index -- Back Cover.
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| 520 |
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|a Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology.
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| 650 |
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|a Metabolites.
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| 650 |
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0 |
|a Immunology.
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| 650 |
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6 |
|a Métabolites.
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| 655 |
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7 |
|a Electronic books.
|2 local
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| 700 |
1 |
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|a Ryan, Tristram A. J.
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| 710 |
2 |
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|a ScienceDirect (Online service)
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| 776 |
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|i Print version:
|z 0443154473
|z 9780443154478
|w (OCoLC)1381443037
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| 856 |
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|u http://proxy.library.tamu.edu/login?url=https://www.sciencedirect.com/science/book/9780443154478
|z Connect to the full text of this electronic book
|t 0
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| 955 |
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|a Elsevier ScienceDirect 2026-2027
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| 994 |
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|a 92
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| 952 |
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|a Texas A&M University
|b College Station
|c Electronic Resources
|s www_evans
|d Available Online
|t 0
|e QP171
|h Library of Congress classification
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| 998 |
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f |
|a QP171
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|l Available Online
|