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APPLIED RAMAN SPECTROSCOPY : concepts, instrumentation, chemometrics, and life science applications.

Applied Raman Spectroscopy: Concepts, Instrumentation, Chemometrics, and Life Science Applications synthesizes recent developments in the field, providing an updated overview.

Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: [S.l.] : Elsevier, 2025.
Subjects:
Raman spectroscopy.
Spectroscopie Raman.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Applied Raman Spectroscopy: Concepts, Instrumentation, Chemometrics, and Life Science Applications
  • Copyright Page
  • Dedication
  • Contents
  • List of contributors
  • 1 Introduction of basic theory and principle of Raman scattering and spectroscopy
  • 1.1 Background
  • 1.2 Raman spectroscopy
  • 1.2.1 Theoretical principles: a quantum mechanical approach
  • 1.2.2 Theoretical background of surface-enhanced Raman spectroscopy
  • 1.2.3 Types of Raman spectroscopy
  • 1.2.3.1 Surface-enhanced Raman spectroscopy
  • 1.2.3.2 Ultrafast and non-linear surface-enhanced Raman spectroscopy
  • 1.2.3.3 Spatially offset Raman spectroscopy
  • 1.2.3.4 Transmission Raman spectroscopy
  • 1.2.3.5 Resonance Raman spectroscopy
  • 1.2.3.6 Spontaneous Raman spectroscopy
  • 1.2.3.7 Time-resolved Raman spectroscopy
  • 1.2.3.8 Tip-enhanced Raman spectroscopy
  • 1.2.3.9 Micro-Raman spectroscopy
  • 1.2.4 Hybrid techniques of Raman spectroscopy
  • 1.2.5 Instrumentations
  • 1.2.6 Applications
  • 1.2.6.1 Biological applications
  • 1.2.6.2 Mineralogical applications
  • 1.2.6.3 Cultural heritages
  • 1.2.6.4 Quality control and analytical processes
  • 1.2.7 Limitations and advantages of Raman spectroscopy
  • 1.3 Conclusion
  • Conflicts of interests
  • References
  • 2 Overview of the basics of resonance Raman spectroscopy, applications, and recent advances
  • 2.1 Introduction
  • 2.1.1 Historical context and development of resonance Raman spectroscopy
  • 2.1.2 Definition and significance of resonance Raman effect
  • 2.2 Applications and importance in interdisciplinary research
  • 2.3 Theory of resonance Raman spectroscopy
  • 2.3.1 Overview of electronic transitions and resonance conditions
  • 2.3.2 Derivation of the Raman scattering intensity in resonance conditions
  • 2.3.3 Resonance Raman enhancement factors and their significance.
  • 2.3.4 Theoretical models for interpreting resonance Raman spectra
  • 2.3.5 Factors influencing resonance Raman scattering efficiency
  • 2.4 Instrumentation for resonance Raman spectroscopy
  • 2.4.1 Components of a typical Raman spectrometer
  • 2.4.2 Spectral sources for resonance Raman experiments
  • 2.4.3 Raman excitation wavelength selection methods
  • 2.4.4 Sample handling and experimental setup considerations
  • 2.4.5 Recent advancements in instrumentation for improved sensitivity and resolution
  • 2.5 Experimental techniques and data analysis
  • 2.5.1 Choice of excitation wavelengths and chromophore selection
  • 2.5.2 Sample preparation and handling considerations
  • 2.5.3 Data acquisition and preprocessing methods
  • 2.5.4 Data analysis and interpretation techniques
  • 2.5.5 Strategies for overcoming common experimental challenges
  • 2.6 Applications of resonance Raman spectroscopy
  • 2.6.1 Biochemical and biomedical applications
  • 2.6.2 Materials science and nanotechnology applications
  • 2.6.3 Characterization of carbon-based materials
  • 2.6.4 Semiconductor nanomaterials analysis
  • 2.6.5 Environmental and atmospheric applications
  • 2.6.5.1 Monitoring pollutants and atmospheric species
  • 2.6.5.2 Studying environmental photochemistry and photobiology
  • 2.6.6 Pharmaceutical and drug development applications
  • 2.6.6.1 Detection and quantification of drug compounds
  • 2.6.6.2 In situ analysis of drug-protein interactions
  • 2.6.7 Raman spectroscopy in food technology
  • 2.6.7.1 Application of Raman spectroscopy in testing fruit and vegetable quality and safety
  • 2.6.7.2 Resonance Raman spectroscopy techniques in food analysis
  • 2.6.7.2.1 Spectroscopic techniques
  • 2.6.7.2.2 Chromatographic techniques
  • 2.6.7.2.3 Microbiological techniques
  • 2.6.7.2.4 Aspect of quality inspection
  • 2.6.7.2.5 Aspect of safety inspection.
  • 2.6.7.2.6 Detection of contaminants
  • 2.6.7.2.7 Quality control and assurance
  • 2.6.7.2.8 Shelf life determination
  • 2.7 Recent advances in resonance Raman spectroscopy
  • 2.7.1 Ultrafast time-resolved resonance Raman spectroscopy
  • 2.7.2 Surface-enhanced resonance Raman scattering
  • 2.7.3 Coherent anti-Stokes Raman scattering techniques
  • 2.7.4 Single-molecule resonance Raman spectroscopy
  • 2.7.5 Advancements in instrumentation for high-throughput analysis
  • 2.8 Future perspectives and challenges
  • References
  • 3 Remote Raman spectroscopy in nanoscale optics
  • 3.1 Introduction
  • 3.2 Nanoscale optics and plasmonics
  • 3.2.1 Surface plasmon polaritons
  • 3.2.2 Optical excitation of surface plasmon
  • 3.2.2.1 Prism coupling
  • 3.2.2.2 Grating coupling
  • 3.2.2.3 High numerical-aperture objective coupling
  • 3.2.2.4 Near-field excitation
  • 3.2.3 Confocal scanning optical microscopy
  • 3.3 Quantum emitters
  • 3.3.1 Quantum dots
  • 3.3.2 Color centers in diamond
  • 3.4 Fabrication of plasmonic structures
  • 3.4.1 Physical methods
  • 3.4.2 Chemical methods
  • 3.5 Plasmon influenced Raman spectroscopy
  • 3.5.1 Surface-enhanced Raman scattering
  • 3.5.1.1 Electromagnetic enhancement
  • 3.5.1.2 Chemical enhancement
  • 3.5.2 Beamed Raman scattering
  • 3.5.3 Remote Raman scattering
  • 3.6 Conclusion
  • Acknowledgment
  • References
  • 4 Theoretical developments, instrumentation, and biological applications of surface-enhanced Raman spectroscopy
  • 4.1 Introduction
  • 4.1.1 Surface-enhanced Raman spectroscopy substrate
  • 4.1.2 Surface-enhanced Raman spectroscopy analyte
  • 4.2 Theory of surface-enhanced Raman spectroscopy
  • 4.2.1 Localized surface plasmon polaritons
  • 4.2.2 Enhancement factor
  • 4.2.3 Electromagnetic enhancement
  • 4.2.4 Distance dependence
  • 4.2.5 Chemical enhancement
  • 4.2.6 Further developments.
  • 4.2.7 Surface-enhanced Raman spectroscopy hotspots
  • 4.3 Instrumentation
  • 4.3.1 Hotspot generation by nanoparticle self-assembly, tip probe, and shell formation
  • 4.3.2 Hotspot generation by coupled nanostructures
  • 4.4 Biological applications
  • 4.4.1 Biocompatibility
  • 4.4.2 Biomedical applications
  • 4.4.2.1 Live cells
  • 4.4.3 Detection of pathogens
  • 4.4.4 Biomolecules
  • 4.4.5 Proteins
  • 4.4.6 Metabolites
  • 4.4.7 DNA
  • 4.4.8 Other applications
  • 4.5 Future outlook
  • Acknowledgment
  • References
  • 5 Tip-enhanced Raman spectroscopy: fundamentals and applications
  • 5.1 Introduction
  • 5.1.1 Techniques to improve infrared absorption and scattering
  • 5.2 Concept of tip-enhanced infrared spectroscopy
  • 5.3 Instrumentation for tip-enhanced infrared spectroscopy
  • 5.4 Advancement in tip-enhanced Raman spectroscopy
  • 5.5 Chemical analysis by tip-enhanced Raman spectroscopy
  • 5.5.1 Future directions
  • References
  • 6 Stimulated Raman scattering microscopy: principles and life science applications
  • 6.1 Introduction
  • 6.2 Principle of stimulated Raman scattering microscopy
  • 6.2.1 Improvement in chemical sensitivity and enhancing spatial resolution
  • 6.3 Life science applications
  • 6.3.1 Applications of stimulated Raman scattering microscopy in drug tracking and microbial detection
  • 6.4 Conclusions
  • References
  • 7 Biomedical and clinical applications of Raman spectroscopy and multivariate chemometric methods
  • 7.1 Introduction
  • 7.2 Data acquisition and preprocessing
  • 7.2.1 "Cleaning-up" of the data
  • 7.2.2 Background and baseline removal
  • 7.2.3 Normalization
  • 7.2.4 Columnwise preprocessing
  • 7.3 Multivariate analysis for pattern recognition
  • 7.3.1 Unsupervised chemometric analysis
  • 7.3.2 Supervised linear techniques for classification
  • 7.3.3 Deep-learning algorithms
  • 7.4 Future perspectives
  • References.
  • 8 Raman spectroscopy and chemometrics: a potential method for life science applications
  • 8.1 Introduction: the case for Raman fingerprinting in life sciences
  • 8.2 Spectral complexity of biological molecules and samples
  • 8.3 Chemometric modeling approach
  • 8.4 Case study: Escherichia coli phenotypic responses to erythromycin exposure
  • 8.5 Spectral processing
  • 8.5.1 Spectral averaging and truncation
  • 8.5.2 Wavenumber calibration
  • 8.5.3 Baselining
  • 8.5.4 Normalization
  • 8.6 Unsupervised models
  • 8.6.1 Principal component analysis
  • 8.6.2 Clustering
  • 8.6.3 k-Means clustering
  • 8.6.4 Distance formulas
  • 8.6.5 Total principal component distance
  • 8.6.6 Hierarchical clustering
  • 8.6.7 Gaussian mixture models
  • 8.7 Supervised learning models
  • 8.7.1 Purpose and types of models
  • 8.7.2 Multivariate analysis of variance
  • 8.7.3 Supervised model testing
  • 8.7.4 Probability density function clustering
  • 8.7.5 Discriminant analysis of principal components
  • 8.7.6 Discriminant analysis of principal components model performance metrics
  • 8.7.7 Principal component regression and partial least squares regression
  • 8.8 Molecular contributions
  • 8.9 Using a model for predictions
  • 8.10 Conclusions and moving forward
  • References
  • 9 Raman-gene integration provides a novel space of information to explore metabolism and gene function
  • 9.1 Introduction
  • 9.2 Key studies
  • 9.3 Experimental approaches and considerations for Raman-gene integration
  • 9.4 Conclusion
  • References
  • 10 Raman spectroscopic studies on mineralized tissues and skin appendages
  • 10.1 Raman characteristic spectra for tissue characterization
  • 10.1.1 Mineralized tissues-bone and teeth
  • 10.1.2 Skin appendages-hair and nails
  • 10.2 Raman spectroscopic studies for tissue characterization
  • 10.3 Raman spectroscopy in forensic science.