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Meiosis in development and disease /

Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The initiation stages of meiosis, The molecular basis and dynamics of meiotic cohesions,...

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Bibliographic Details
Main Author: Cole, Francesca (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: London, England ; San Diego, California ; Cambridge, Massachusetts : Academic press, [2023]
Series:Issn.
Subjects:
Meiosis.
Méiose.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Meiosis in Development and Disease
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Mechanism of initiation of meiosis in mouse germ cells
  • 1. Introduction
  • 2. STRA8 plays a key role in the initiation of meiosis
  • 3. MEIOSIN interacts with STRA8 during meiotic initiation
  • 4. MEIOSIN and STRA8 direct the switch from mitosis to meiosis
  • 5. MEIOSIN together with STRA8 determines meiotic entry
  • 6. MEIOSIN and STRA8 activate meiotic prophase program
  • 7. MEIOSIN and STRA8 boost the transcription of the meiotic genes
  • 8. Sexual difference of meiotic initiation
  • 9. Evolutionary conservation and divergence in the meiotic entry system
  • 10. Conclusion
  • Acknowledgments
  • Conflict of interest statement
  • References
  • Chapter Two: Orchestrating recombination initiation in mice and men
  • 1. Introduction-Orchestrating the critical stages of recombination initiation
  • 2. Germline replication timing affects broad-scale recombination patterning
  • 3. Chromatin loop array formation and loop extrusion
  • 4. Creating an accessible local chromatin environment
  • 5. Chromatin opening meiosis-specific Pioneer Complex
  • 6. Associate putative hotspot sites in the DNA loops with the chromosomal axis
  • 6.1. DSB formation
  • 7. Facilitating efficient homology engagement and DSB repair
  • 8. PRDM9 redundant meiotic recombination initiation
  • 9. Summary
  • References
  • Chapter Three: Cancer and meiotic gene expression: Two sides of the same coin?
  • 1. Introduction
  • 1.1. Role of meiotic genes in cancer
  • 2. Global DNA demethylation
  • 3. Histone modifications
  • 4. DNA accessibility
  • 5. Higher-order of chromatin structure
  • 5.1. Topologically associated domains
  • 5.2. Distal regulatory elements
  • 5.3. R-loops
  • 6. Conclusions
  • Acknowledgments
  • Author contributions
  • References.
  • Chapter Four: Phase separation in controlling meiotic chromosome dynamics
  • 1. Chromosome dynamics during meiosis
  • 2. Phase separation to form biomolecular condensates in cells
  • 3. Phase separation in controlling chromatin organization and activities
  • 4. Phase separation in meiotic recombination initiation
  • 5. Phase separation in homologous chromosome pairing
  • 5.1. DSB-independent pairing
  • 5.2. DSB-dependent pairing
  • 6. Phase separation in synapsis
  • 7. Potential phase separation in mammalian sex body formation
  • 8. Perspectives
  • Acknowledgments
  • References
  • Chapter Five: Meiotic chromosome organization and its role in recombination and cancer
  • 1. Chromatin and chromosome organization during meiosis
  • 2. Evolution of the core axis proteins and the synaptonemal complex
  • 3. Morphogenesis and remodeling of the chromosome axis
  • 4. Roles of chromosomal axis proteins in DSB and crossover formation during meiosis
  • 5. Does the chromosome axis play a role in CO interference?
  • 6. Temperature-based regulation of axis proteins and the impact on recombination
  • 7. Aberrant expression of the HORMADs and SC proteins regulates intrinsic DNA repair activities in somatic cancer cells
  • Acknowledgments
  • References
  • Chapter Six: Chromosome-specific behaviors during early meiosis
  • 1. Introduction
  • 2. What is meiosis?
  • 3. How do chromosomes differ from each other?
  • 4. Association between meiotic errors and chromosome structure in humans
  • 5. Regulation of crossing over on different chromosomes
  • 5.1. Regulation of DSBs and crossing over varies on different chromosomes
  • 5.2. Chromosome-specific defects occur with defective synapsis
  • 5.3. Chromosome-specific meiotic regulators
  • 6. Chromatin composition can influence multiple aspects of meiosis.
  • 6.1. Chromatin environment can alter timing of meiotic events between chromosomes
  • 6.2. Meiotic sex chromosome inactivation separates sex chromosomes from autosomes
  • 7. Aspects of chromosome biology that alter meiotic nuclear organization
  • 7.1. rDNA location affects pairing and nuclear organization
  • 7.2. Specialized chromosome-specific proteins pair homologs in C. elegans
  • 7.3. Changes in chromosome structure alter nuclear organization
  • 8. Other examples of chromosome-specific defects
  • 9. Summary
  • Acknowledgments
  • References
  • Chapter Seven: Emerging mechanisms and roles of meiotic crossover repression at centromeres
  • 1. Introduction
  • 2. The ``centromere´´ effect
  • 3. Mechanisms of meiotic crossover repression at centromeres
  • 4. Saccharomyces cerevisiae
  • 5. Schizosaccharomyces pombe
  • 6. Caenorhabditis elegans
  • 7. Drosophila melanogaster
  • 8. Plants
  • 9. Mammals
  • 10. Pericentric crossovers and chromosomal mis-segregation
  • 11. Role of pericentric crossovers in human diseases
  • 12. Future perspectives
  • Acknowledgment
  • References
  • Chapter Eight: Unwinding during stressful times: Mechanisms of helicases in meiotic recombination
  • 1. Introduction
  • 1.1. Architecture and mechanism of nucleic acid helicases
  • 1.2. Meiotic recombination
  • 2. Helicases and meiotic recombination
  • 2.1. Formation of meiotic DSB breaks
  • 2.1.1. HELLS helicase
  • 2.2. Break resection
  • 2.2.1. Sgs1 and Dna2 in break resection
  • 2.3. Presynaptic filament formation
  • 2.3.1. Srs2
  • 2.3.2. Rad54 (I)
  • 2.4. Interhomolog bias
  • 2.4.1. Rad54 (II)
  • 2.4.2. Mph1
  • 2.5. D-loop formation
  • 2.5.1. Mer3
  • 2.5.2. Pif1
  • 2.6. Crossover decision
  • 2.6.1. Sgs1
  • 3. Summary
  • Acknowledgments
  • References
  • Chapter Nine: Meiotic crossover interference: Methods of analysis and mechanisms of action
  • 1. Introduction.
  • 2. Methods for measuring crossover interference
  • 2.1. Genetic analysis
  • 2.2. Cytological analysis
  • 3. Complications in interpreting interference data
  • 4. Proteins required for crossover interference
  • 5. Models of crossover interference
  • 5.1. Trigger model
  • 5.2. Polymerization models
  • 5.3. Reaction-diffusion models
  • 5.4. Counting models
  • 5.5. Mechanical models
  • 5.6. Chromosome oscillatory movement model
  • 5.7. Clustering models
  • 6. Conclusions and future research
  • Acknowledgments
  • References
  • Further reading
  • Chapter Ten: Small RNAs and their protein partners in animal meiosis
  • 1. Introduction
  • 2. RNA binding proteins in non-coding RNA pathways
  • 2.1. Biogenesis of miRNA
  • 2.2. Biogenesis of siRNA
  • 2.3. Processing of miRNA and siRNA in the cytoplasm
  • 2.4. Loading of small RNAs into Argonaute proteins and post-transcriptional gene silencing
  • 3. Roles for small RNAs and associated RBPs in the germline
  • 4. Meiotic silencing of unpaired chromatin
  • 5. Meiotic silencing of sex chromatin
  • 6. Pericentromeric heterochromatin remodeling during meiosis
  • 7. Regulation of meiotic recombination and double strand break repair
  • 8. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Eleven: Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics
  • 1. Mitotic and meiotic checkpoints
  • 2. Unique requirements of meiotic prophase
  • 3. The meiotic prophase checkpoint
  • 4. The logic of the spindle assembly checkpoint
  • 5. The meiotic prophase checkpoint: Logic and open questions in light of the SAC
  • 6. Meiotic checkpoint factors in cancer?
  • Acknowledgments
  • References
  • Chapter Twelve: PCH-2 and meiotic HORMADs: A module for evolutionary innovation in meiosis?
  • 1. Introduction
  • 2. The PCH-2/HORMAD module
  • 3. The role of meiotic HORMADs.
  • 4. PCH-2/Pch2/PCH2/TRIP13 in meiosis
  • 5. Localization of PCH-2
  • 6. Role in pairing and synapsis
  • 7. Role in recombination
  • 8. Role in regulating meiotic progression
  • 9. Requirement for a cofactor
  • 10. A unified model of PCH-2s role in meiotic prophase
  • 11. Conclusion
  • References
  • Chapter Thirteen: In vitro spermatogenesis: Why meiotic checkpoints matter
  • 1. Introduction
  • 2. Key meiotic events during meiosis
  • 2.1. Key events of meiotic prophase I
  • 2.1.1. DSB formation, early DSB repair, and chromosome synapsis in vitro
  • 2.1.2. Complete chromosome synapsis, establishment of MSCI, XY body formation, and crossovers in vitro
  • 2.2. Key events of the meiotic metaphases
  • 2.2.1. Chiasmata formation and chromosome segregation during meiotic metaphases in vivo
  • 2.2.2. Chiasmata formation in vitro
  • 2.3. Spermiogenesis-The formation of elongated spermatids
  • 2.3.1. Formation of round spermatid-like cells and elongated spermatid-like cells in vitro
  • 3. Meiotic checkpoint mechanisms
  • 3.1. Investigation of meiotic checkpoints in vitro
  • 4. Prospects of in vitro spermatogenesis for research or clinical use
  • 4.1. Evaluation of in vitro-derived germ cells
  • 4.2. Concluding remarks on possible future applications
  • Acknowledgments
  • References.