NATURAL BIOPOLYMERS FOR DRUG DELIVERY.

Natural Biopolymers for Drug Delivery thoroughly details the properties, benefits and challenges of using these biomaterials in drug delivery, with a strong focus on biocompatibility and reduction of unwanted interactions.

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Format:	eBook
Language:	English
Published:	[S.l.] : WOODHEAD PUBLISHING, 2025.
Series:	Woodhead Publishing series in biomaterials.
Subjects:	Polymeric drug delivery systems. Drug delivery systems. Drug Delivery Systems Médicaments polymères > Administration > Dispositifs. Systèmes d'administration de médicaments. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Natural Biopolymers for Drug Delivery
Copyright Page
Contents
List of contributors
Preface
1 Introduction of natural biopolymers
1.1 Introduction
1.2 Biological origin
1.3 Examples of natural biopolymers
1.3.1 Cellulose
1.3.2 Starches
1.3.3 Chitin and chitosan
1.3.4 Alginate
1.3.5 Gellan gum
1.3.6 Pectins
1.3.7 Gum Arabica
1.3.8 Guar gum
1.3.9 Locust bean gum
1.3.10 Carrageenan
1.3.11 Hyaluronic acid
1.3.12 Collagen
1.3.13 Gelatin
1.3.14 Chondroitin sulfate
1.3.15 Albumin
1.3.16 Deoxyribonucleic acid
1.4 Properties and characteristics
1.5 Processing and modification
1.5.1 Extraction
1.5.2 Purification
1.5.3 Chemical modification
1.6 Biocompatibility and health applications
1.6.1 Drug delivery
1.6.2 issue engineering
1.6.3 Wound healing
1.6.4 Other healthcare applications
1.7 Environmental impact
1.8 Challenges and limitations
1.9 Research and innovation
1.10 Future prospects
1.11 Conclusion
References
2 Gum Arabic in drug delivery
2.1 Introduction
2.2 Major sources
2.3 Properties of Gum Arabic
2.3.1 Physical properties
2.3.2 Chemical properties
2.3.3 Biological properties
2.4 Production processes
2.4.1 Mechanical process
2.4.2 Spray drying process
2.4.3 Agglomeration process
2.5 Advantage and disadvantage
2.6 Application of Gum Arabic in drug delivery
2.6.1 Excipient in tablets
2.6.2 Hydrogels
2.6.3 Carrier of microspheres
2.6.4 Additive in films
2.6.5 Wall forming material of microcapsules
2.6.6 Carrier of nanoparticles
2.6.7 Modified conjugates in drug delivery
2.6.8 Coating material of nanoparticles
2.6.9 Emulsifying agent
2.6.10 Anticancer activity
2.7 Conclusions
References
3 Gum tragacanth in drug delivery
3.1 Introduction.
3.2 Gum tragacanth in pharmaceutical formulations
3.2.1 Emulsification and stabilization
3.2.2 Thickening and viscosity modification
3.2.3 Film formation and coating
3.3 Benefits of use in drug delivery
3.4 Drug delivery systems
3.4.1 Tablets
3.4.2 Suspensions
3.4.3 Emulsions
3.4.4 Hydrogels
3.4.5 Nanofibers
3.5 Hurdles and considerations in working with gum tragacanth
3.6 Conclusion
References
4 Pectin in drug delivery
4.1 Introduction
4.2 Overview of pectin
4.2.1 Properties of pectin
4.2.1.1 Chemical structure
4.2.1.2 General properties
4.2.2 Modification of pectin
4.2.2.1 Physical methods
Ultrasonication
Pressure-based techniques
High-speed shearing
Pulsed electric field
Ionizing Irradiation
Cold plasma
Microwave treatment
UV/H2O2 mediated degradation
4.2.2.2 Chemical methods
4.2.2.3 Enzymatic methods
4.2.2.4 Combined methods
4.2.3 Pectin in biomedical application
4.3 Pectin-based drug delivery system
4.3.1 Hydrogel
4.3.2 Aerogel
4.3.3 Nanocarrier
4.3.3.1 Nanocapsules
4.3.3.2 Nanoparticle
4.3.4 Complexation
4.3.5 Emulsion
4.4 Conclusion
References
5 Cellulose in drug delivery
5.1 Introduction
5.2 Cellulose nanoparticles: nanocellulose
5.3 Cellulose for drug and gene delivery
5.4 Conclusions
References
6 Starch in drug delivery
Abbreviations and acronyms
6.1 Introduction
6.2 Starch microspheres
6.3 Starch films
6.4 Starch hydrogels
6.5 Starch nanocrystals-nanoparticles
6.6 Conclusion
References
7 Guar gum in drug delivery
7.1 Introduction
7.2 Chemistry of guar gum
7.3 Health benefits of guar gum
7.4 Toxicology of guar gum
7.5 Guar gum-based devices for drug delivery
7.5.1 Guar gum-based prodrug
7.5.2 Guar gum-based devices via chemical modification.
7.5.3 Guar gum-based devices via coordination crosslinking strategy
7.5.4 Guar gum-based devices via chemical crosslinking strategy
7.5.5 Guar gum-based devices via polymerization crosslinking strategy
7.5.6 Guar gum-based devices via physically crosslinking strategy
7.5.6.1 Original guar gum
7.5.6.2 Modified guar gum
7.6 Conclusions
Acknowledgments
References
8 Locust bean gum in drug delivery
Abbreviations
8.1 Introduction
8.2 Structure and properties
8.2.1 Origin, composition, and biosynthesis
8.2.2 Physicochemical properties
8.2.3 Possibleimpurities
8.2.4 Synergistic behaviors of locust bean gum
8.2.4.1 Xanthan gum
8.2.4.2 Carrageenan
8.2.4.3 Miscellaneous
8.2.5 Locust bean gum derivatives
8.3 Biodegradation
8.4 Processing
8.4.1 Extraction and Manufacturing
8.4.2 Purity and Quality Control Test
8.5 Application in Drug Delivery System
8.5.1 Tablets
8.5.2 Microparticles
8.5.3 Nanoparticles
8.5.4 Hydrogels
8.5.5 Polymeric films
8.6 Other applications
8.6.1 Tissue engineering
8.6.2 Solubility enhancement of poorly water-soluble drugs
8.7 Conclusion
References
9 Okra gum in drug delivery
9.1 Introduction: out of Africa, into the world
9.1.1 The plant
9.2 The gum
9.2.1 Preparation
9.2.2 Characteristics
9.2.3 Chemical modifications
9.2.3.1 Carboxymethylation
9.2.3.2 Thiolation
9.2.3.3 Sulfation
9.2.3.4 Blending
9.2.3.5 Grafting
9.3 Pharmaceutical applications
9.3.1 Okra gum as a film coating agent
9.3.2 Okra gum as tablet binder
9.3.3 Okra gum as suspending agent
9.3.4 Okra gum as hydrophilic matrix for controlled release
9.3.4.1 Carboxymethylation
9.3.4.2 Thiolation
9.3.4.3 Sulfation
9.3.4.4 Blending
9.3.4.5 Grafting
9.3.4.6 Microspheres
9.3.4.7 Nanoparticles.
9.3.4.8 Nanocomposite film
9.3.4.9 Buccal patches
9.3.4.10 Vaccine delivery
9.4 Outlook
References
10 Cashew gum in drug delivery
10.1 Introduction to cashew
10.2 Natural product gum and cashew gum
10.3 How can cashew gum be applied in biomedicine?
10.4 Adverse effect of cashew gum
10.5 Cashew gum and drug delivery
10.5.1 General concept
10.5.2 Preparation for cashew gum-based drug delivery system
10.5.2.1 Microwave-initiated rapid synthesis
10.5.2.2 Ionotropic-gelation
10.5.2.3 Nanoprecipitation and dialysis
10.5.2.4 Gum acetylation
10.5.2.5 Nanoencapsulation
10.5.3 Applied nanomaterial technology with cashew gum
10.5.3.1 Nanoparticle
10.5.3.2 Nanoemulsion
10.5.3.3 Nanocomposite
10.5.3.4 Nanogel
10.5.4 Route for cashew gum-based drug delivery
10.5.4.1 Transdermal route
10.5.4.2 Oral route
10.5.4.3 Injection
10.5.5 Drug that can be delivered by cashew gum-based drug delivery
10.5.5.1 Amphotericin B
10.5.5.2 Indomethacin
10.5.5.3 Diclofenac
10.5.5.4 Epiisopiloturine
10.5.5.5 Insulin
10.6 Conclusion
Conflict of interest
References
11 Sterculia gum in drug delivery
Abbreviations
11.1 Introduction
11.2 Overview of sterculia gum
11.2.1 History and source of sterculia gum
11.2.2 Extraction and marketing
11.2.3 Applications
11.2.3.1 Medical application
11.2.3.2 Drug delivery
Development of floating drug delivery systems
Microspheres development for drug delivery at specific sites
Microencapsulation of the drug
11.2.3.3 Bulk laxative
11.2.3.4 Nanoparticles synthesis
11.2.3.5 Wound plaster and dressing
11.2.3.6 Food industry
11.3 Properties of sterculia gum
11.3.1 Chemical composition
11.3.2 Physicochemical properties.
11.4 Pharmaceutical formulations and dosage forms of sterculia gum in drug delivery
11.4.1 Tablets
11.4.2 Hydrogels
11.4.3 Nanoparticles
11.4.4 Films
11.5 Conclusion
References
12 Alginates in drug delivery
12.1 Introduction
12.2 Routes for alginate extraction
12.3 Significant factors for the use of alginates as drug delivery system
12.4 Pure and hybrid applications of alginates as drug delivery system
12.5 Conclusions
References
13 Agar agar in drug delivery
13.1 Introduction
13.2 Agarose properties and functionalities
13.3 Agaropectin and its application
13.4 Agar-agar and its copolymer functionality and performance
13.5 Agar-agar in drug delivery systems
13.6 Conclusion
References
14 Chitin and chitosan in drug delivery
14.1 Introduction
14.2 Properties of chitin and chitosan
14.3 Chitin and chitosan in drug delivery
14.3.1 Tablets
14.3.2 Capsules
14.3.3 Hydrogels
14.3.4 Vescicular drug delivery systems
14.3.5 Particulate drug delivery systems
14.3.6 Microsponges
14.3.7 Patches and films
14.4 Conclusion
Acknowledgments
References
15 Gellan gum in drug delivery
15.1 Introduction
15.2 Structure and physicochemical properties of gellan gum
15.3 Drug administration routes for gellan gum formulations
15.3.1 Nasal administration route
15.3.2 Ocular administration route
15.3.3 Oral administration route
15.3.4 Buccal administration route
15.4 Conclusion
References
16 Xanthan gum in drug delivery
16.1 Introduction
16.2 Structure and properties of xanthan gum
16.3 Formulation strategies utilizing xanthan gum
16.3.1 Sustained-release formulations
16.3.2 Targeted drug delivery systems
16.3.3 Mucoadhesive drug carriers
16.3.4 Nanoparticulate systems
16.4 Applications of xanthan gum in drug delivery.