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Recent advances in nanomedicines mediated wound healing /

Recent Advances in Nanomedicines Mediated Wound Healing presents an overview of various nanotechnology-based drug delivery systems explored widely for wound healing. The book provides a comprehensive review of thriving strategies used for wound healing and thoroughly describes the most recent develo...

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Bibliographic Details
Main Author: Kesharwani, Prashant (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: London, United Kingdom : Academic Press is an imprint of Elsevier, 2025.
Subjects:
Wound healing > Technological innovations.
Nanomedicine.
Nanomedicine
Cicatrisation > Innovations.
Nanomédecine.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Recent Advances in Nanomedicines Mediated Wound Healing
  • Copyright Page
  • Dedication
  • Contents
  • List of contributors
  • About the author
  • Preface
  • Acknowledgment
  • 1 Introduction and types of wounds
  • 1.1 Introduction
  • 1.2 Types of wounds
  • 1.2.1 Normal wound
  • 1.2.2 Open wound
  • 1.2.3 Closed wound
  • 1.3 Wound healing process
  • 1.3.1 Hemostasis phase
  • 1.3.2 Inflammatory phase
  • 1.3.3 Proliferation phase
  • 1.3.4 Remodeling phase
  • 1.4 Factors affecting the wound healing process
  • 1.5 Chronic wound
  • 1.5.1 Ulcers
  • 1.5.2 Diabetic wound
  • 1.6 Wound dressing properties
  • 1.7 Using nanotechnology for wound healing
  • 1.7.1 Nanomaterials as intrinsic therapeutic agents
  • 1.7.1.1 Metallic and metal oxide nanomaterials
  • 1.7.1.1.1 Gold nanoparticles
  • 1.7.1.1.2 Silver nanoparticles
  • 1.7.1.1.3 Zinc oxide nanoparticles
  • 1.7.1.2 Nonmetallic nanomaterials
  • 1.7.1.2.1 Carbon nanotubes
  • 1.7.1.2.2 Graphene
  • 1.7.1.2.3 Fullerenes
  • 1.7.2 Nanostructures as carriers of therapeutic agents
  • 1.7.2.1 Nitric oxide containing nanocarriers
  • 1.7.2.2 Controlled drug delivery systems
  • 1.7.2.3 Nanoengineered scaffolds for wound healing
  • 1.8 Challenges in the use of nanoparticles for wound healing
  • 1.9 Conclusions
  • References
  • 2 Plant-based nanomaterials: an effective wound healing medicine
  • 2.1 Introduction
  • 2.2 Plant as a source of wound healing nanomedicine
  • 2.3 Significance of plant-based nanomedicines
  • 2.4 Wound healing approaches of nanomedicines
  • 2.5 Plant-based silver nanoparticles for wound healing
  • 2.5.1 Plant-based gold nanoparticles for wound healing
  • 2.5.2 Plant-based other nanoparticles for wound healing
  • 2.5.3 Plant-based nanostructures for wound healing
  • 2.5.4 Plant-based nanomedicines for diabetic wound healing
  • 2.6 Conclusion
  • Acknowledgments
  • References.
  • 3 Curcumin-mediated nanomedicines for wound healing
  • 3.1 Introduction
  • 3.1.1 Wound types and healing process
  • 3.1.2 Factors impairing wound healing
  • 3.1.2.1 Local wound conditions
  • 3.1.2.2 Concomitant conditions
  • 3.1.2.3 Other factors that alter inflammatory and immune response
  • 3.1.2.4 Lifestyle
  • 3.2 Curcumin: properties, wound healing efficacy, and limitations
  • 3.3 Wound healing efficacy of curcumin nanomedicines
  • 3.3.1 Polymeric micelles
  • 3.3.2 Polymeric nanoparticles
  • 3.3.3 Nanofibers
  • 3.3.4 Nanocomposites
  • 3.3.5 Nanoemulsions
  • 3.3.6 Lipid nanoparticles
  • 3.4 Conclusion/summary
  • Acknowledgment
  • Conflict of interest
  • References
  • 4 Green synthesis of nanoparticles for wound healing
  • 4.1 Introduction
  • 4.1.1 Overview of wound healing
  • 4.2 Stages of wound healing
  • 4.3 Factors affecting wound healing
  • 4.3.1 Intrinsic factors
  • 4.3.1.1 Age
  • 4.3.1.2 Sex hormones
  • 4.3.1.3 Genetics
  • 4.3.1.4 Systemic diseases
  • 4.3.2 Extrinsic factors
  • 4.3.2.1 Oxygenation
  • 4.3.2.2 Infection
  • 4.3.2.3 Nutrition
  • 4.3.2.4 Alcoholism
  • 4.3.2.5 Obesity
  • 4.3.2.6 Stress
  • 4.3.3 Iatrogenic factors
  • 4.3.3.1 Medications
  • 4.3.4 Diabetic wound healing challenges
  • 4.3.4.1 Pathophysiology of diabetic wounds
  • 4.3.4.2 Types of diabetic wounds
  • 4.3.5 Diagnosis and classification of diabetic wounds
  • 4.3.6 Different types of diagnostic tests used for diabetic wounds
  • 4.3.7 Factors contributing to delayed wound healing in diabetic patients
  • 4.3.8 Nanotechnology in diabetic wound healing
  • 4.3.9 Types of nanoparticle synthesis
  • 4.3.9.1 Chemical precipitation
  • 4.3.9.2 Sol-Gel method
  • 4.3.9.3 Thermal decomposition
  • 4.3.9.4 Microemulsion
  • 4.3.9.5 Electrochemical deposition
  • 4.3.9.6 Vapor deposition
  • 4.3.9.7 Green synthesis
  • 4.3.10 Different types of nanoparticles
  • 4.3.10.1 Metal nanoparticles.
  • 4.3.10.2 Semiconductor nanoparticles
  • 4.3.10.3 Magnetic nanoparticles
  • 4.3.10.4 Carbon-based nanoparticles
  • 4.3.10.5 Oxide nanoparticles
  • 4.3.10.6 Polymer nanoparticles
  • 4.3.10.7 Lipid-based nanoparticles
  • 4.3.10.8 Composite nanoparticles
  • 4.3.10.9 Composite metal oxide nanoparticles
  • 4.3.10.10 Silica nanoparticles
  • 4.3.10.11 Ceramic nanoparticles
  • 4.3.10.12 Core-shell nanoparticles
  • 4.3.10.13 Dendrimers
  • 4.3.10.14 Janus nanoparticles
  • 4.3.10.15 Upconversion nanoparticles
  • 4.3.11 Different types of nanocomposites
  • 4.4 Plant-based therapeutics for wound healing
  • 4.4.1 Phytochemicals with wound healing properties
  • 4.4.1.1 Flavonoids
  • 4.4.1.2 Polyphenols
  • 4.4.1.3 Terpenoids
  • 4.4.1.4 Alkaloids
  • 4.4.2 Medicinal plants with wound healing potential
  • 4.4.2.1 Aloe vera
  • 4.4.2.2 Calendula
  • 4.4.2.3 Centella asiatica
  • 4.4.2.4 Turmeric
  • 4.4.3 Mechanisms of action
  • 4.4.4 Application of plant-based therapeutics
  • 4.4.5 Clinical evidence and studies
  • 4.4.6 Effectiveness of copper nanoparticles in wound healing process
  • 4.4.7 Zinc oxide nanoparticles in diabetic wound healing
  • 4.5 Conclusion
  • References
  • 5 Wound healing approaches based on polysaccharide-nanoparticles biocomposites
  • 5.1 Introduction
  • 5.2 Wound healing
  • 5.2.1 The wound healing process
  • 5.2.2 Wound dressings
  • 5.2.2.1 Types of wound dressings
  • 5.2.2.2 Polymeric dressings
  • 5.2.2.3 Biocomposite dressings
  • 5.3 Polysaccharide-based biomaterials for wound healing
  • 5.3.1 Polysaccharides as structuring materials
  • 5.3.2 Bioactive polysaccharides
  • 5.3.2.1 Antioxidant activity
  • 5.3.2.2 Anti-inflammatory action
  • 5.3.2.3 Antimicrobial properties
  • 5.3.2.4 Wound-healing capacity
  • 5.3.2.5 Anti-cancer activity
  • 5.4 Polysaccharide nanoparticles for wound healing
  • 5.4.1 Nanoparticles
  • 5.4.1.1 Synthesis of nanoparticles.
  • 5.4.1.2 Nanoparticles and their properties and applications
  • 5.4.2 Polysaccharide-metallic nanoparticles biocomposites
  • 5.5 The future of polysaccharide-nanoparticles biocomposites in wound healing
  • References
  • 6 Microsphere-mediated approaches for wound healing applications
  • 6.1 Introduction
  • 6.2 Types of microspheres used in wound healing
  • 6.3 Mechanisms of microsphere-mediated wound healing
  • 6.4 Experimental techniques and characterization methods
  • 6.5 Applications of microsphere-based therapies
  • 6.6 Clinical considerations and challenges
  • 6.7 Future directions and conclusions
  • Declaration of competing interest
  • Acknowledgments
  • References
  • 7 Nanoemulsion mediated approaches for wound healing
  • 7.1 Introduction
  • 7.2 Structure of nanoemulsions
  • 7.3 Components of nanoemulsions
  • 7.3.1 Lipophilic phase
  • 7.3.2 Surfactants
  • 7.3.2.1 Classification of surfactants
  • 7.3.2.1.1 Synthetic surfactants
  • 7.3.2.1.2 Natural surfactants
  • 7.3.3 Cosurfactants
  • 7.4 Forms of nanoemulsions
  • 7.4.1 Oil-in-water nanoemulsions
  • 7.4.2 Water-in-oil nanoemulsions
  • 7.4.3 Bicontinuous nanoemulsions
  • 7.5 Forms of micelles
  • 7.5.1 Regular micelles
  • 7.5.2 Reverse micelles
  • 7.5.3 Unimolecular micelles
  • 7.6 Preparation methodologies
  • 7.6.1 High energy methods
  • 7.6.1.1 High-pressure homogenization
  • 7.6.1.2 Microfluidization
  • 7.6.1.3 Ultra-sonication
  • 7.6.1.4 Jet disperser
  • 7.6.2 Low energy methods
  • 7.6.2.1 Phase inversion temperature
  • 7.6.2.2 Spontaneous emulsification
  • 7.6.2.3 Solvent displacement method
  • 7.7 Destabilization and stabilization of nanoemulsions
  • 7.7.1 Destabilization
  • 7.7.2 Driving forces for preparing stable nanoemulsions specialized in wound healing
  • 7.8 Characterization of nanoemulsions for skin care
  • 7.8.1 Particle size determination
  • 7.8.2 Morphology.
  • 7.8.3 Refractive index
  • 7.8.4 Visual observation
  • 7.8.5 In vitro skin permeation
  • 7.8.6 Skin irritation
  • 7.9 Advantages of nanoemulsions in wound healing
  • 7.10 Mechanism of wound healing
  • 7.10.1 Mechanism of wound healing as a general
  • 7.10.2 Skin permeation pathways
  • 7.10.3 Mechanism of drug release to skin via nanoemulsions
  • 7.10.3.1 Mechanisms of hydrophilic drug release to skin via nanoemulsions
  • 7.10.3.1.1 Boosting drug permeability
  • 7.10.3.1.2 Fine-tuning the electrostatic profile of ionic therapeutics
  • 7.10.3.1.3 Solubilization of sebum by nanoemulsions
  • 7.10.3.1.4 Follicular delivery
  • 7.10.3.2 Mechanisms of hydrophobic drug release to skin via nanoemulsions
  • 7.10.3.2.1 Disruption of the stratum corneum lipid bilayers
  • 7.10.3.2.2 Nanosizing of oil droplets
  • 7.10.3.2.3 Positively charged nanoemulsions
  • 7.10.3.2.4 Reducing the nanoemulsion viscosity
  • 7.10.3.2.5 Hydrating the skin
  • 7.11 Biofilm development in wounds and suppression (i.e., cleansing) mechanism
  • 7.11.1 Biofilm development in wounds
  • 7.11.2 Biofilm suppression (i.e., wound cleansing) mechanisms
  • 7.12 Challenges
  • 7.13 Conclusions
  • References
  • 8 Nanohydrogel mediated approaches for wound healing
  • 8.1 Introduction
  • 8.2 The function of nanomaterials in hydrogel dressings for wound care
  • 8.3 The typical substances employed in crafting nanohydrogel for wound healing
  • 8.3.1 Collagen
  • 8.3.2 Gelatin
  • 8.3.3 Fibrin
  • 8.3.4 Chitosan
  • 8.3.5 Cellulose
  • 8.3.6 Hyaluronic acid
  • 8.3.7 Polyethylene glycol
  • 8.4 Conclusion
  • References
  • 9 Smart bioactive hydrogel-based films loaded with nanoparticles for wound healing
  • 9.1 Introduction
  • 9.2 Wound healing process
  • 9.3 Classification of wounds
  • 9.4 Biopolymer-based hydrogels.