Mitophagy in health and disease : mechanisms, health implications, and therapeutic opportunities /
Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specif...
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| Format: | eBook |
| Language: | English |
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London :
Academic Press,
[2025]
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Mitophagy in Health and Disease
- Copyright Page
- Contents
- List of contributors
- About the editor
- Preface
- 1 The invitation
- 2 Why edit this book?
- 3 The contents
- 1 PINK1-Parkin quality control mitophagy pathway in Parkinson's disease
- Introduction
- Parkin, PINK1, and Parkinson's disease
- Discovery of a PINK1-Parkin stress-responsive quality control pathway
- Mechanism of PINK1-Parkin stress response pathway
- Step 1: PINK1 adopts an active conformation on the OMM following mitochondrial import failure
- PINK1 import and proteolysis in healthy mitochondria
- PINK1 sorting to the OMM and activation following mitochondrial import block
- Step 2: Parkin activation by PINK1
- Step 3: activated Parkin ubiquitinates OMM proteins in the vicinity of PINK1
- Step 4: ubiquitinated mitochondria are degraded by mitophagy
- Mitophagy in physiologic contexts
- Mitophagy in mammalian neurons
- Mito QC in the mitochondrial fission-fusion cycle
- PINK1-Parkin mitophagy in Drosophila
- PINK1-Parkin pathway in mice
- Therapeutic development
- Enhancing PINK1 activity
- Enhancing Parkin activity
- Other enhancers of PINK1-Parkin mitophagy
- Perspective on the therapeutic potential PINK1-Parkin pathway modulation
- Conclusion
- References
- 2 Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions
- Introduction
- Ubiquitin-dependent and -independent pathways of mitophagy
- BCL2 family protein-mediated mitophagy
- BNIP3-mediated mitophagy
- BNIP3L-mediated mitophagy
- BCL2L13-mediated mitophagy
- FUNDC1-mediated mitophagy
- FKBP8-mediated mitophagy
- PHB2-mediated mitophagy
- NIPSNAP1- and NIPSNAP2-mediated mitophagy
- Lipids in mitophagy
- Cardiolipin
- Ceramide
- Connection of ubiquitin-dependent and -independent mitophagy
- Conclusion and perspectives
- References.
- 3 Role of AMPK/ULK1 signaling in mitophagy
- Abbreviations
- Introduction
- Mitophagy: a brief overview of molecular mechanisms
- Structure, subcellular localization, and regulation mechanisms of AMPK
- Molecular structure and activation of AMPK
- Subcellular localization of AMPK
- AMPK signaling in the cytoplasm
- AMPK signaling in the nucleus
- Lysosomes as a crucial hub to mediate AMPK activation and signaling
- Role of AMPK at the endoplasmic reticulum
- Mitochondrial localization of AMPK
- AMPK signaling in the functional crosstalk between mitochondrial dynamics and mitophagy
- Role of the AMPK/ULK1 axis in regulation of the mitophagy cascade
- Concluding remarks
- References
- 4 Mitochondrial proteases
- Abbreviations
- Mitochondrial protease network
- Mitochondrial processing peptidases
- Oligopeptidases
- Quality control proteases
- i-AAA and m-AAA
- LonP
- ClpXP
- PARL, HTRA2, and OMA1
- The mitochondrial unfolded protein response (mtUPR)
- Mitochondrial proteases as emerging pharmacological targets
- Concluding remarks
- References
- Further reading
- 5 The mitochondrial unfolded protein response in health and disease
- Abbreviations
- Introduction
- Activation and regulation of the mitochondrial stress response (UPRmt)
- UPRmt activation in Caenorhabditis elegans
- UPRmt activation in mammals
- Chromatin remodeling and UPRmt activation
- Noncanonical pathways that mediate a mitochondrial stress response in mammals
- UPRmt sirtuin axis
- The estrogen receptor alpha axis
- UPRmt and the integrated stress response
- Effects of UPRmt activation in health and disease
- UPRmt and aging
- UPRmt and cardiovascular diseases
- UPRmt and cancer
- UPRmt and neurodegenerative diseases
- UPRmt and mitochondrial diseases
- Prolonged activation of the UPRmt.
- Mitochondrial stress response and mitophagy in recovery of the mitochondrial network
- References
- 6 Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles
- Abbreviations
- Introduction
- Mitochondrial quality control
- Mitochondria-derived vesicles
- Mechanisms of MDV formation
- The roles of MDVs in inflammation
- Release of mitochondrial content within extracellular vesicles
- Nature of the mitochondrial content within EVs
- Roles of mitoEVs
- Conclusion
- References
- 7 Molecular regulation of mitochondrial turnover by exercise: tissue adaptation through mitochondrial biogenesis and mitophagy
- Introduction
- Skeletal muscle form and function: important considerations
- Effect of exercise on skeletal muscle mitochondria turnover
- Mechanisms of exercise-mediated mitochondrial biogenesis and mitophagy
- Energy sensor AMPK regulates exercise-induced mitochondrial biogenesis and mitophagy
- Contraction-induced calcium release activates mitochondrial biogenesis and mitophagy
- Exercise-induced ROS signaling promotes mitochondrial turnover in skeletal muscle
- Effect of exercise on mitochondrial biogenesis and mitophagy in other tissues
- Conclusion
- References
- 8 Role of mitophagy and mitochondria in aging and cellular senescence
- List of abbreviations
- Introduction
- Mitochondrial DNA, mitochondrial function, and aging
- Mitochondrial dynamics and aging
- Mitochondrial dysfunction, ROS production, and aging
- Mitochondrial dysfunction, sirtuins, and aging
- Mitophagy and aging
- Mitophagy and cell senescence
- Mitophagy, immunity, and aging
- Mitophagy, neurodegeneration, and aging
- Mitophagy and cardiac aging
- Mitophagy and oocyte aging
- Conclusions
- References
- 9 Mitophagy in erythropoiesis
- Abbreviations
- Introduction.
- Mitochondria clearance and normal red blood cell maturation
- Mitophagy relevance during erythroid maturation
- Mitophagy can be conducted by different molecular pathways
- Mitophagy regulation in erythropoiesis
- Mitophagy associated to hematological disorders
- Concluding remarks
- References
- 10 The dual role of mitophagy in cancer and its targeting for effective anticancer therapy
- Abbreviations
- Introduction
- Brief insights into mitophagy mechanisms
- Role of mitophagy in cancer
- Mitophagy in tumor suppression
- Metabolic reprogramming
- Regulation of cell proliferation and cell death
- Maintenance of oxidative stress
- Targeting inflammasome activation
- Mitophagy in tumor growth and progression
- Maintenance of mitochondrial homeostasis in cancer cells
- Promotion of cancer cell survival and therapy resistance
- Maintenance of cancer stem cells
- Therapeutic targeting of mitophagy for effective anticancer strategy
- Conclusion
- References
- 11 Mitophagy and neurodegenerative disease
- Abbreviations
- Introduction
- Mitophagy in AD
- Mitophagy in PD
- Mitophagy in HD
- Mitophagy in ALS
- Mitophagy in stroke
- Cerebellar atrophy
- Mitophagy as a potential therapeutic target for neurodegenerative disease
- Small molecules targeting PINK1/Parkin
- Therapeutic targets on other mitophagic pathways
- Therapeutic targets on antioxidative stress
- Therapeutic targets on antiinflammation
- Physical effects
- Future perspectives
- References
- 12 The antiaging role of mitophagy
- Abbreviations
- Introduction
- The molecular pathways of mitophagy
- The phosphatase and tensin homolog-induced putative kinase 1/Parkin pathway
- Receptor-mediated mitophagy
- Alterations in mitophagy during aging and age-related diseases
- Alterations in mitophagy during aging.
- Alterations in mitophagy of age-related diseases
- The antiaging role of mitophagy
- Compounds that act as mitophagy modulators
- Calorie restriction and exercise promote longevity
- Conclusions
- References
- 13 Compromised mitophagy in aging and neurodegenerative diseases
- Abbreviations
- Introduction
- Mitophagy
- PINK-Parkin-dependent mitophagy
- PINK-Parkin-independent mitophagy
- Receptor-mediated mitophagy
- Ubiquitin ligase-mediated mitophagy
- Compromised mitophagy in aging
- Compromised mitophagy in Alzheimer's disease
- Compromised mitophagy in Parkinson's disease
- Compromised mitophagy in amyotrophic lateral sclerosis diseaset?
- Mitophagy in Huntington's disease
- Concluding remarks
- References
- 14 Mitophagy inducers as potential therapeutic agents
- Why inducing mitophagy is a promising medical strategy
- A detailed discussion of the mechanisms of action of five well-characterized inducers of mitophagy
- Berberine as an inducer of mitophagy
- Resveratrol as an inducer of mitophagy
- Rapamycin as an inducer of mitophagy
- Spermidine as an inducer of mitophagy
- Metformin as an inducer of mitophagy
- Behavior of mitophagy inducers in animal models
- Other benefits and safety concerns of mitophagy inducers
- Other potential inducers of mitophagy
- Concluding remarks
- References
- 15 Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family
- Introduction
- The lay of the land: mitophagy players
- Mitochondrial malfunction
- AMPK, the puppet master
- Regulation of autophagy by AMPK
- Lysosomal biogenesis: planning ahead
- AMPK and communication between mitochondria and lysosomes
- TFEB regulation
- TFEB and autophagy
- TFEB and mitophagy
- TFEB and mitochondrial biogenesis
- Concluding remarks
- References
- 16 Cardioprotection through mitophagy.