Three functional states of proteins : structured, intrinsically disordered, and phase separated /

Explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and inn...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Tripathi, Timir (Editor), Uversky, Vladimir N. (Editor)
Format:	eBook
Language:	English
Published:	London, U.K. : Academic Press, [2025]
Subjects:	Proteins. Proteins > Structure. Proteins Intrinsically Disordered Proteins Protein Structural Elements Protéines. Protéines > Structure. protein. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Chapter 1. The three functional states of proteins: beyond the classical "lock and key" paradigm
Chapter 2. Ordered proteins and structure-function relationship: a classical view
Chapter 3. Binding of a substrate ("lock and key") and conformational adaption ("induced fit") are different stages of enzyme action
Chapter 4. Intrinsically disordered proteins: functionality of chaos
Chapter 5. Protein conformation-based phenotypic switching and implications in the origin and evolution of multicellularity
Chapter 6. Hybrid proteins: fusion chimeras and natural wonders
Chapter 7. Functional protein oligomers
Chapter 8. Fuzzy complexes
Chapter 9. SMARTQ: single-molecule amyloid fibRil tracking and quantification. A method for accurately imaging, tracking, and quantifying the growth of individual amyloid fibrils using TIRF
Chapter 10. Structural polymorphism in amyloids--states within proteins' solid-state
Chapter 11. Liquid-liquid phase separation, biomolecular condensates, and membraneless organelles: a novel blueprint of intracellular organization
Chapter 12. Physical principles and molecular interactions underlying protein phase separation
Chapter 13. Various levels of phase transitions in the protein universe and around
Chapter 14. Targeting phase separated protein states for drug discovery
Chapter 15. Protein hydrogels: structure, characteristics, and applications
Chapter 16. Interactions among the three protein states
Chapter 17. Frustration and fuzziness in the three functional states of proteins
Chapter 18. Thermoresponsive intrinsically disordered protein polymers
Chapter 19. The evolution and exploration of intrinsically disordered and phase-separated protein states
Chapter 20. Computational modeling of intrinsically disordered and phase-separated protein states
Chapter 21. Molecular dynamics simulations of intrinsically disordered proteins, fuzzy complexes, and phase-separated protein states
Chapter 22. Biological complexity of the phase-separated protein states
Chapter 23. Protein structure-function continuum.