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Multitasking molecular chaperone Hsp60 : structure, function, and impact on health and disease /

The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Cappello, Francesco (Editor), Conway de Macario, Everly (Editor), Macario, Alberto J. L. (Editor)
Format: eBook
Language:English
Published: London, U.K. ; San Diego, CA : Academic Press, [2025]
Subjects:
Heat shock proteins.
Molecular chaperones.
Molécules chaperonnes.
Protéines de choc thermique.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • The Multitasking Molecular Chaperone Hsp60
  • The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease
  • Copyright
  • Contents
  • Contributors
  • Preface
  • One
  • The chaperone system and its diseases: Introductory overview focusing on Hsp60
  • 1. The chaperone system
  • 2. The chaperonopathies
  • 3. Hsp60
  • 4. Components and properties of the CS
  • 5. Mapping the CS components in tissues and cells
  • 6. The chapters
  • References
  • Two
  • Physical and biochemical properties of the molecular chaperone Hsp60
  • 1. Hsp60, a member of the chaperone system
  • 2. Oligomeric structure and allosteric states
  • 3. Structural diversity of Hsp60 with implications for pathology
  • 4. Further comments on Hsp60 functional diversity
  • 5. Hsp60 post-translational modifications
  • 5.1 Acetylation
  • 5.2 Nitration and S-nitrosylation
  • 5.3 Phosphorylation
  • Acknowledgments
  • References
  • Three
  • The spectrum of human Hsp60 genetic variants and associated chaperonopathies
  • 1. Introduction. Human Hsp60 chaperonin: origin, and physiological and physiopathological roles
  • 2. Chaperonopathies and Hsp60-associated chaperonopathies
  • 3. Hsp60 genetic chaperonopathies affecting the nervous system