http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Pathophysiological aspects of proteases in cancer
1 online resource (xxii, 625 pages) : color illustrations
Provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
Chapter 1. Pathophysiological aspects of calpains in cancer -- Chapter 2. Mitochondrial proteases in cancer development and progression -- Chapter 3. Proteases in head and neck cancer -- Chapter 4. Matrix metalloproteinases and uveal melanoma -- Chapter 5. Proteases in DNA damage, repair, and radioresistance: Cellular and molecular aspects -- Chapter 6. Radiotherapy, proteases and gastric cancer: A complex interplay -- Chapter 7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma -- Chapter 8. Exploring synthetic and natural compounds for cathepsin B: Mechanisms and therapy -- Chapter 9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer -- Chapter 10. Ubiquitin specific protease 3,7 in bone cancer and squamous cell carcinoma -- Chapter 11. Serine protease: Structure, classification, mechanism and role in breast cancer -- Chapter 12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and a novel therapeutic targets for gastric cancer -- Chapter 13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer -- Chapter 14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis -- Chapter 15. Cathepsins as diagnostic and prognostic markers in oral cancer -- Chapter 16. Role of kallikreins in prostate cancer -- Chapter 17. Mechanistic aspects of serine protease as biomarkers in wound healing of lung cancer -- Chapter 18. The role of acetylcholinesterase in cancer development and possible therapeutic applications -- Chapter 19. Therapeutics of animal-derived compounds in proteases-induced cancer -- Chapter 20. Molecular warriors: Proteases as sentinels in the war against cancer diagnosis and prognosis --
Chapter 21. Serine proteases and their contribution to chemoresistance in cancer -- Chapter 22. Cathepsins, chemoresistance, and cancer -- Chapter 23. Matrix metalloproteinases, chemoresistance and cancer -- Chapter 24. MMPs (-2 and -9)-mediated drug resistance and their reversal in gynecological cancer -- Chapter 25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer -- Chapter 26. Role of proteasome in the development of chemoresistance in multiple myeloma -- Chapter 27. Role of cysteine cathepsin and matrix metalloproteinases in progression and chemoresistance in ovarian and breast cancer -- Chapter 28. Proteases, chemoresistance, and cancer -- Chapter 29. Breaking barriers: Proteases as key players in cancer chemoresistance -- Chapter 30. Matrix metalloproteases-targeting low-molecular-weight compounds -- Chapter 31. Evidence from clinical trials on synthetic protease inhibitors in oral, head, and neck cancer -- Chapter 32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: Results of clinical trials -- Chapter 33. Side effects of synthetic protease inhibitors used in gynecology cancers -- Chapter 34. The role of synthetic protease inhibitors in breast cancer -- Chapter 35. Cathepsin-responsive nanomaterials for targeted delivery of malignant tumors.
edited by Sajal Chakraborti, Srijit Das, Cheorl-Ho Kim.
Includes bibliographical references and index.