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Oxazole, isoxazole, benzoxazole-based drug discovery /

Oxazole, Isoxazole, Benzoxazole Based Drug Discovery offers complete coverage of oxazole and related molecules, both from natural and synthetic origin, with a focus on the reaction mechanisms, and medicinal, pharmacokinetic and computational aspects.

Bibliographic Details
Main Authors: Hussain, Erum Akbar (Author), Ghani, Ambreen (Author), Sadiq, Zubi (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: Amsterdam, Netherlands ; Cambridge, MA : Elsevier, [2025]
Series:Heterocyclic drug discovery series
Subjects:
Drug development.
Oxazoles.
Oxazoles
Médicaments > Développement.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Oxazole, Isoxazole, Benzoxazole-Based Drug Discovery
  • Copyright Page
  • Contents
  • 1 Introduction
  • 1.1 Introduction
  • 1.1.1 Natural sources
  • 1.1.2 Marine sources
  • 1.1.3 Terrestrial source
  • 1.2 Extraction methods
  • 1.3 Purification techniques and structure elucidation
  • 1.3.1 Chemistry
  • 1.3.2 Biological significance
  • 1.3.3 Drug discovery and development
  • References
  • 2 Oxazoles
  • 2.1 Introduction
  • 2.2 General methods of synthesis of oxazole
  • 2.2.1 Transition metal-catalyzed synthesis
  • 2.2.2 Van Leusen approach for an oxazole ring
  • 2.2.3 Robinson-Gabriel route toward oxazoles
  • 2.2.4 Aza-Wittig approach for oxazole synthesis
  • 2.2.5 Fischer synthesis of oxazole
  • 2.3 Marketed drugs containing the oxazole ring
  • 2.3.1 Oxaprozin
  • References
  • 3 Isoxazole
  • 3.1 Introduction
  • 3.2 General methods for synthesis of isoxazole
  • 3.3 Marketed drugs containing isoxazole nucleus
  • 3.3.1 Broxaterol
  • 3.3.2 Isocarboxazid
  • 3.3.3 Sulfamethoxazole
  • 3.3.4 Zonisamide
  • 3.3.5 Sulfisoxazole
  • 3.3.6 Parecoxib sodium
  • 3.3.7 Valdecoxib
  • 3.3.8 Risperidone
  • 3.3.9 Leflunomide
  • 3.3.10 Danazol
  • 3.3.11 Androisoxazole
  • 3.3.12 Isoxazolyl penicillins: cloxacillin, dicloxacillin, flucloxacillin, and oxacillin
  • References
  • 4 Benzoxazole
  • 4.1 Introduction
  • 4.2 General approaches for the synthesis of benzoxazole
  • 4.3 Marketed drugs containing benzoxazoles
  • 4.3.1 Flunoxaprofen
  • 4.3.2 Benoxaprofen
  • 4.3.3 Zoxazolamine
  • 4.3.4 Tafamidis
  • References
  • 5 Oxazolone
  • 5.1 General methods for synthesis of oxazolone
  • 5.1.1 Erlenmeyer synthesis
  • 5.2 Marketed drugs containing the oxazolone nucleus
  • 5.2.1 Chlorzoxazone
  • 5.2.2 Cyclazodone
  • 5.2.3 Thozalinone
  • 5.2.4 Fenozolone
  • References
  • 6 Oxadiazole
  • 6.1 Introduction
  • 6.1.1 1,2,3-Oxadiazoles
  • 6.1.2 1,2,4-Oxadiazole
  • 6.1.3 1,3,4-Oxadiazole
  • 6.2 General methods for synthesis of oxadiazoles
  • 6.2.1 Synthesis of 1,2,4-oxadiazoles
  • 6.2.1.1 Synthesis of 1,3,4-oxadiazoles
  • 6.3 Marketed drugs having an oxadiazole scaffold
  • 6.3.1 1,2,3-Oxadiazoles
  • 6.3.2 Molsidomine
  • 6.3.3 1,2,4-Oxadiazoles
  • 6.3.4 Ataluren
  • 6.3.5 Azilsartan medoxomil
  • 6.3.6 Butalamine
  • 6.3.7 Imolamine
  • 6.3.8 Fasiplon
  • 6.3.9 Opicapone
  • 6.3.10 Ozanimod
  • 6.3.11 Oxolamine
  • 6.3.12 Prenoxdiazine
  • 6.3.13 Proxazol citrate
  • 6.3.14 Pleconaril
  • 6.3.15 1,2,5-Oxadiazole
  • 6.3.16 Furazabol
  • 6.3.17 1,3,4-Oxadiazoles
  • 6.3.18 Furamizole
  • 6.3.19 Nesapidil
  • 6.3.20 Raltegravir
  • 6.3.21 Tiodazosin
  • 6.3.22 Fenadiazole
  • References
  • 7 Oxazolidinone
  • 7.1 Introduction
  • 7.2 Synthetic approaches for oxazolidinone
  • 7.2.1 Catalyst-free approaches for oxazolidinone
  • 7.2.2 Catalyst-mediated approaches for oxazolidinones
  • 7.2.3 Organocatalyst-mediated synthesis of oxazolidinone
  • 7.3 Marketed drugs having the oxazolidinone scaffold
  • 7.3.1 Terizidone
  • 7.3.2 Metaxalone
  • 7.3.3 Tedizolid phosphate