The Rose and Mackay textbook of autoimmune diseases /
**Selected for 2025 Doody's Core Titles® with "Essential Purchase" designation in Allergy/Clinical Immunology**The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision,...
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| Format: | eBook |
| Language: | English |
| Published: |
[Place of publication not identified] :
Academic Press,
2024.
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| Edition: | Seventh edition. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- 9780443239472v1_WEB
- Front Cover
- The Rose and Mackay Textbook of Autoimmune Diseases
- Copyright Page
- Dedication
- Contents to Volume 1
- List of contributors
- List of editors and section editors
- Editors
- Section editors
- Basic science
- Ear nose and throat
- Dermatology
- Endocrinology
- Hematology
- Hepatobiliary and gastroenterology
- Nephrology
- Neurology
- Ophthalmology
- Pulmonary
- Rheumatology
- Preface
- 1 Basic science: development of the immune system with cell lineages
- 1. Development of adaptive immune cells
- Self versus nonself
- Adaptive immune cell development
- Lymphocyte progenitors
- T cell development
- Altered mechanisms of T cell tolerance as promoters of autoimmunity
- B cell development
- Antibody diversity
- Self-reactive B cells are inherently part of the peripheral B cell pool
- Altered mechanisms of B cell tolerance and autoimmunity
- Conclusion
- Acknowledgment
- References
- 2. Revision to the origins of the mononuclear phagocyte
- Key points
- Overview
- Steady-state development of macrophages
- Transcriptional regulation of tissue-resident macrophages
- Common macrophage transcriptional profiles
- Adipose tissue macrophages
- Cardiac tissue macrophages
- Intestinal macrophages
- Kupffer cells
- Langerhans cells
- Peritoneal macrophages
- Lung macrophages
- Brain macrophages
- Nerve-associated macrophages
- Osteoclasts
- Splenic macrophages
- Synovial macrophages
- M1 and M2 paradigm revisited
- Future directions
- References
- 3. Tolerance and activation of peripheral B and T cells
- B cell central tolerance "checkpoints" in humans
- Tonic signaling at the immature B cell stage
- Receptor editing is likely a dominant tolerance mechanism at the immature B cell stage in mice and humans.
- The special case of immature B cell deletion in response to DNA-protein complexes
- T cell activation, T-B collaboration, and peripheral B cell tolerance
- Self-reactive B cells at the transitional B cell stages are likely most susceptible to receptor downregulation and subseque...
- Late transitional and mature follicular B cells are anergized by selective downregulation of IgM, but anergic B cells are a...
- An overview of T cell tolerance and peripheral T cell activation
- The simultaneous generation of CD4+ T cell subsets and the induction of the extrafollicular response
- The transient extrafollicular induction of autoimmunity after infection likely reflects the major contribution of self-reac...
- The extrafollicular response, tolerance, and common autoimmune disorders
- Regulatory T cells in the maintenance of B cell tolerance
- Autoantibodies in common variable immunodeficiency likely reflect altered T effector/T reg ratios that allow anergic B cell...
- Germinal center B cell tolerance may reflect a default process and a break in tolerance at this location may lead to frank ...
- Conclusion
- Acknowledgments
- References
- 4. Genetic alterations leading to autoimmunity
- Introduction
- The genetics of autoimmunity before development of the genome-wide association study
- Evidence supporting the role of genetics in autoimmune diseases
- Linkage studies in autoimmune diseases
- Candidate gene studies identify the first non-HLA associated autoimmune disease risk genes
- The genome-wide association study
- Genome-wide association study discover a trove of autoimmune disease associations
- Fine mapping autoimmune disease loci with the Immunochip
- Moving from genetic association to functional mechanism in the post-GWAS era
- The next technology advance: single cell sequencing.
- Leveraging polygenic risk scores to predict disease
- Summary
- References
- 5. Microbiome in autoimmunity
- Introduction
- Alterations in the gut microbiome in autoimmune diseases
- Inflammatory bowel diseases
- Type 1 diabetes
- Multiple sclerosis
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Mechanisms
- Metabolites
- Molecules mimicry
- Microbiota translocation
- Interventions
- Diet and metabolites
- Fecal microbiota transplantation
- Inflammatory bowel diseases
- Type 1 diabetes
- Multiple sclerosis
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Conclusion
- References
- 6. Metabolic control of pathogenesis in autoimmune diseases
- Short summary
- Introduction
- Systemic lupus erythematosus
- Mitochondrial oxidative stress underlies mTOR activation in SLE
- Rheumatoid arthritis
- Autoimmune spondyloarthritis
- Scleroderma and systemic sclerosis
- Metabolic control of organ-specific autoimmune diseases
- Conclusions
- Acknowledgments
- References
- 7. Triggers for autoimmunity
- Introduction
- Self-antigens that escape tolerance
- Neoantigens
- Breaking tolerance to existing autoantigens
- Enhanced presentation of posttranslationally modified epitopes
- Cryptic epitopes
- Sequestered antigens
- Environmental triggers of autoimmunity
- Viral-induced autoimmunity
- Epstein-Barr virus
- Enterovirus
- Hepatitis C virus
- Herpes simplex virus
- SARS-CoV-2
- Drug-induced autoimmunity
- Drug-induced lupus
- Potential mechanisms of drug-induced lupus
- Cellular autoimmunity
- Neutrophil extracellular traps
- Immune checkpoint inhibitor-induced autoimmunity
- Potential mechanisms of immune checkpoint inhibitor-induced autoimmunity
- Cellular autoimmunity
- Humoral autoimmunity
- Cytokine production
- Conclusion
- References
- 8. Organ damage in autoimmune disease.
- Introduction
- Initiation of tissue injury
- Antibody-mediated tissue injury
- Organ-specific diseases initiated by autoantibodies
- Autoantibodies of unknown function
- Antibodies directed at ubiquitous self-antigens
- B cells as organizers of local inflammation
- B cell-directed therapies
- T cell-mediated tissue injury
- T cells as inflammatory effector cells
- Antigen-specific T cells
- T cells as B cell helpers or regulatory cells
- T cell-directed therapies
- Innate immune mechanisms
- Macrophages
- Neutrophils
- Innate lymphoid cells
- Soluble inflammatory mediators
- Soluble mediators of resolution
- Chronic tissue injury
- Hypoxia
- Immune senescence
- Cell death
- Fibrosis
- Fibroblasts
- Pro-fibrotic and antifibrotic soluble mediators
- Targeting fibrosis
- Failed resolution
- Genetics of tissue injury
- Loss of function
- Implications for therapy
- References
- 9. Therapeutic strategies for treating autoimmune disease
- Immunosuppression versus targeted therapy
- B cell depletion
- T cell-directed therapy
- Cytokine blockade
- Small molecule immune inhibitors
- Immunoablation and reconstitution
- Antigen-specific therapy
- Conclusion
- References
- 2 Rheumatology
- 10. Systemic lupus erythematosus
- Introduction
- History
- Disease diagnosis and classification
- Epidemiology, genetics, and the environment
- Pathogenesis
- Adaptive immunity
- Innate immunity
- Clinical features
- Clinical presentation
- Mucocutaneous manifestations
- Arthritis
- Renal involvement
- Neuro-psychiatric disease
- Hematologic manifestations
- Pulmonary and cardiovascular manifestations
- Other clinical manifestations
- Infections
- Clinical laboratory findings
- Treatment
- Outcome measures
- General therapeutic schema
- Therapeutic agents
- Antimalarials
- Corticosteroids
- Biologics.
- Immunosuppressive medications
- Calcineurin inhibitors
- Cyclophosphamide
- Supportive treatments
- Future directions
- References
- 11. Systemic sclerosis (scleroderma)
- Definition and classification
- Epidemiology and etiology
- Sex bias, ethnic background and mortality trends
- Environmental factors
- Pathogenesis
- Genetic associations
- Preclinical disease models
- Microvascular disease in systemic sclerosis
- Inflammation and autoimmunity
- Cellular immunity
- Humoral autoimmunity
- Fibrosis
- Pathology
- Skin
- Lungs
- Gastrointestinal tract
- Kidneys
- Heart
- Pathology in other organs
- Clinical features
- Overview
- Initial clinical presentation
- Organ involvement
- Raynaud's phenomenon
- Skin features
- Pulmonary features
- Interstitial lung disease
- Gastrointestinal involvement
- Renal involvement: scleroderma renal crisis
- Cardiac involvement
- Musculoskeletal complications
- Less recognized disease manifestations
- Biomarkers and autoantibodies in systemic sclerosis
- Screening and follow-up evaluation
- Management of patients with systemic sclerosis
- General principles
- Disease-modifying immunomodulatory therapy
- Therapy targeting fibrosis
- Vascular therapy
- Treatment of gastrointestinal complications
- Treatment of interstitial lung disease
- Management of renal crisis
- Treatment of pulmonary arterial hypertension
- Natural history and prognosis
- References
- 12. Antiphospholipid syndrome
- Historical perspective
- Geoepidemiology
- Pathogenesis
- Double-hit model
- Thrombosis
- Activation of endothelial cells, platelets and immune cells
- Complement activation
- Resistance to activated protein C
- Pregnancy complications
- Proliferation and migration of trophoblasts
- Inflammation
- Complement activation
- Genetics
- Diagnosis, screening, and prevention.