Cover Image

Redox signaling /

Advances in Cancer Research, Volume 162 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Townsend, Danyelle M. (Editor), Schmidt, Ed (Editor)
Format: eBook
Language:English
Published: [Place of publication not identified] : Academic Press, 2024.
Series:Advances in cancer research ; volume 162
Subjects:
Oxidation-reduction reaction.
Oxidation, Physiological.
Cellular signal transduction.
Cancer > Molecular aspects.
Oxydoréduction.
Oxydation biologique.
Transduction du signal cellulaire.
Cancer > Aspect moléculaire.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Advances in Cancer Research
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis
  • 1 Roles and critical requirement of cellular cysteine
  • 1.1 Sources of intracellular cysteine and modes of its entry into cells
  • 1.1.1 De novo Cys synthesis
  • 1.1.2 Cys in cells and in circulation
  • 1.2 GSH in cells and in circulation
  • 1.3 GSSG in cells and in circulation
  • 1.4 Other possible sources of cytosolic cys
  • 1.5 Roles of NADPH, the NADPH-dependent disulfide reductase systems, and redoxins in CSSC reduction
  • 2 Ferroptosis
  • 2.1 Erastin
  • 2.1.1 On- and off-target activities of erastin
  • 2.1.2 Sulfasalazine-similar results as erastin?
  • 2.1.3 Impacts of erastin or SSZ on cellular cystine uptake and Cys or GSH levels
  • 2.2 Protection/prevention against ferroptosis by iron-chelators
  • 2.3 Association with lipid peroxidation
  • 3 Role of GPX4 in ferroptosis
  • 3.1 Kinetics and substrate specificities of GPX4
  • 3.2 Results that question the exact mechanisms of GPX4 targeting in ferroptosis
  • 4 FSP1 and other enzymes affecting ferroptosis in parallel with GPX4
  • 4.1 FSP1
  • 4.2 DHODH
  • 4.3 MBOAT1 and MBOAT2
  • 4.4 Proteins affecting iron status
  • 5 Genetic and pharmacologic models that question the exact roles of cystine, Cys, xCT, GSH, or GSH synthesis in ferroptosis
  • 5.1 CSSC and xCT
  • 5.2 GSSG/GSH and GGT
  • 5.3 GCL disruptions
  • 5.4 GSR KO
  • 6 Potential roles of the thioredoxin system in ferroptosis
  • 7 Concluding remarks
  • Acknowledgments
  • References
  • Chapter Two: Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species
  • 1 Introduction
  • 2 The Protein Tyrosine Phosphatase (PTP) catalytic domain
  • 3 A Cys-based catalytic mechanism and sensitivity to oxidation
  • 4 Sources of Reactive Oxygen Species (ROS) in cellular signaling
  • 5 Oxidation of PTPs I: Cellular mechanisms
  • 6 Oxidation of PTPs II: Structural aspects
  • 7 Conclusions
  • Acknowledgments
  • Disclosure of potential conflicts of interest
  • References
  • Chapter Three: Mitochondrial metallopeptidase OMA1 in cancer
  • 1 Introduction
  • 2 OMA1 and its role in mitochondrial and cellular physiology
  • 3 Redox regulation of OMA1
  • 4 OMA1 and its regulation in cancers
  • 5 Clinical implications
  • 6 Challenges and future directions
  • Acknowledgments
  • Conflict of interest
  • References
  • Chapter Four: Role of antioxidants in modulating anti-tumor T cell immune resposne
  • 1 Introduction
  • 1.1 ROS production by T cells
  • 1.2 Role of ROS in T cell signaling
  • 1.3 Negative impact of ROS on T cell function
  • 1.4 Antioxidant defense mechanisms in T cells
  • 1.5 Sources of ROS in the TME
  • 1.6 Antioxidant molecules and metabolites targeted in anti-tumor immunity
  • 1.7 Clinical trials targeting immune cell antioxidant metabolism