http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Advances in Cancer Research, Volume 162 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
Front Cover -- Advances in Cancer Research -- Copyright -- Contents -- Contributors -- Chapter One: Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis -- 1 Roles and critical requirement of cellular cysteine -- 1.1 Sources of intracellular cysteine and modes of its entry into cells -- 1.1.1 De novo Cys synthesis -- 1.1.2 Cys in cells and in circulation -- 1.2 GSH in cells and in circulation -- 1.3 GSSG in cells and in circulation -- 1.4 Other possible sources of cytosolic cys
1.5 Roles of NADPH, the NADPH-dependent disulfide reductase systems, and redoxins in CSSC reduction -- 2 Ferroptosis -- 2.1 Erastin -- 2.1.1 On- and off-target activities of erastin -- 2.1.2 Sulfasalazine-similar results as erastin? -- 2.1.3 Impacts of erastin or SSZ on cellular cystine uptake and Cys or GSH levels -- 2.2 Protection/prevention against ferroptosis by iron-chelators -- 2.3 Association with lipid peroxidation -- 3 Role of GPX4 in ferroptosis -- 3.1 Kinetics and substrate specificities of GPX4 -- 3.2 Results that question the exact mechanisms of GPX4 targeting in ferroptosis
4 FSP1 and other enzymes affecting ferroptosis in parallel with GPX4 -- 4.1 FSP1 -- 4.2 DHODH -- 4.3 MBOAT1 and MBOAT2 -- 4.4 Proteins affecting iron status -- 5 Genetic and pharmacologic models that question the exact roles of cystine, Cys, xCT, GSH, or GSH synthesis in ferroptosis -- 5.1 CSSC and xCT -- 5.2 GSSG/GSH and GGT -- 5.3 GCL disruptions -- 5.4 GSR KO -- 6 Potential roles of the thioredoxin system in ferroptosis -- 7 Concluding remarks -- Acknowledgments -- References -- Chapter Two: Protein Tyrosine Phosphatase regulation by Reactive Oxygen Species -- 1 Introduction
2 The Protein Tyrosine Phosphatase (PTP) catalytic domain -- 3 A Cys-based catalytic mechanism and sensitivity to oxidation -- 4 Sources of Reactive Oxygen Species (ROS) in cellular signaling -- 5 Oxidation of PTPs I: Cellular mechanisms -- 6 Oxidation of PTPs II: Structural aspects -- 7 Conclusions -- Acknowledgments -- Disclosure of potential conflicts of interest -- References -- Chapter Three: Mitochondrial metallopeptidase OMA1 in cancer -- 1 Introduction -- 2 OMA1 and its role in mitochondrial and cellular physiology -- 3 Redox regulation of OMA1 -- 4 OMA1 and its regulation in cancers
5 Clinical implications -- 6 Challenges and future directions -- Acknowledgments -- Conflict of interest -- References -- Chapter Four: Role of antioxidants in modulating anti-tumor T cell immune resposne -- 1 Introduction -- 1.1 ROS production by T cells -- 1.2 Role of ROS in T cell signaling -- 1.3 Negative impact of ROS on T cell function -- 1.4 Antioxidant defense mechanisms in T cells -- 1.5 Sources of ROS in the TME -- 1.6 Antioxidant molecules and metabolites targeted in anti-tumor immunity -- 1.7 Clinical trials targeting immune cell antioxidant metabolism
edited by Danyelle Townsend, Ed Schmidt.
Advances in cancer research ; volume 162