Caspases as molecular targets for cancer therapy /

Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases.It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities.

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Vaidya, Ankur (Editor)
Format:	eBook
Language:	English
Published:	London : Academic Press, [2024]
Subjects:	Cancer > Chemotherapy. Cancer > Treatment. Cancer > Chimiothérapie. Cancer > Traitement. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
CASPASES AS MOLECULAR TARGETS FOR CANCER THERAPY
CASPASES AS MOLECULAR TARGETS FOR CANCER THERAPY
Copyright
Dedication
Contents
Contributors
About the editor
Preface
1
Introduction to caspases, its function, mechanism, and classification
1. Introduction
2. Caspases
2.1 Molecular structure
2.2 Functions
2.2.1 Caspase's role in apoptosis
2.2.2 Caspases in the regulation of the JAK/STAT signaling pathway
2.2.3 Caspases as inflammatory mediators
2.2.4 Caspases in neurogenesis
2.2.5 Caspases signaling in excitotoxicity
2.3 Mechanism of activation
2.3.1 Intrinsic pathway
2.3.2 Extrinsic pathway
2.4 Classification of caspases
2.4.1 Caspase-1
2.4.2 Caspase-2
2.4.3 Caspase-3
2.4.4 Caspase-4
2.4.5 Caspase-5
2.4.6 Caspase-6
2.4.7 Caspase-7
2.4.8 Caspase-8
2.4.9 Caspase-9
2.4.10 Caspase-10
2.4.11 Caspase-11
2.4.12 Caspase-12
2.4.13 Caspase-13
2.4.14 Caspase-14
3. Conclusions
References
2
Mutations within apoptosis gene and caspases
1. Introduction
1.1 What is apoptosis?
1.2 Importance of apoptosis in cell regulation
1.3 Role of apoptosis genes and caspases in the apoptotic pathway
2. Understanding apoptosis genes
2.1 Key apoptosis genes and their functions
2.2 Impact of mutations on apoptosis genes
2.3 Techniques for identifying apoptosis gene mutations
2.3.1 Electron microscopy
2.3.2 Proteomic and genomic methods
2.3.3 Spectroscopic techniques
2.3.4 Flow cytometry
2.3.5 Detection of the apoptosis using the immunological technique
3. Caspases: The executioners of apoptosis
3.1 Caspase family overview
3.2 Activation and regulation of caspases
3.2.1 Caspase activation by cell surface death receptors
3.2.2 Caspase activation by mitochondrial pathway.
4. Diseases associated with apoptosis gene and caspase mutations
4.1 Cancer and apoptosis gene mutations
4.1.1 Carcinogenesis via intrinsic signaling defects
4.1.2 Carcinogenesis via extrinsic pathway signaling defect
4.2 Neurodegenerative disorders and caspase mutation
4.3 Other genetic diseases linked to apoptotic dysregulation
5. Clinical implications and therapeutic opportunities
5.1 Diagnostic and prognostic applications of apoptosis gene mutations
5.2 Targeting apoptosis for therapeutic interventions
6. Conclusion and future perspectives
References
3
Inflammatory caspase-1, -4, and -5 and their role in anticancer activity
1. Introduction
1.1 Caspase-1, -4, and 5
1.1.1 Structural features of caspase-1, -4, and -5
1.1.2 Types of caspases based on their function and activation mechanism
1.2 Overview of their role in the inflammatory response
1.3 Overview of their potential role in cancer therapy
1.4 Inflammasome
1.5 Protective roles of inflammasomes in cancer
1.6 Pharmacological inhibition of NLRP3 inflammasome
2. Synthetic caspase inhibitors
2.1 Peptide-based inhibitors
2.2 Peptidomimetic inhibitors
2.2.1 Fluoromethyl ketones
2.2.2 Nitriles
2.2.3 Triazoles
2.2.4 Triazines
2.3 Nonpeptidic compounds
2.4 Allosteric caspase inhibitors
2.5 Natural inhibitors
2.5.1 Macromolecular inhibitors
2.5.2 Serpins
2.5.3 X-linked inhibitor of apoptosis protein
2.5.4 Recombinant proteins
2.6 Dual inhibitors
2.7 Miscellaneous
2.8 Conclusion
References
4
Caspase-2 and tumor suppression
1. Introduction
2. Anticancer connection of caspase-2
3. Structural features of caspase-2 regarding its activation and processing
3.1 Caspase recruitment initiation complex-dependent proximity-induced dimerization and conformation.
2.2.5 Neurological implications
2.3 Effects of caspase-7 activators on cellular responses and disease outcomes
3. Activators of caspase-7
3.1 Overview of endogenous activators of caspase-7
3.1.1 Identification and characterization of natural activators
3.1.2 Regulatory mechanisms governing caspase-7 activation
3.1.2.1 Extrinsic and intrinsic cell death
3.1.2.2 Activation of caspases in differentiation
3.2 Exogenous activators and their impact on caspase-7 activation
3.2.1 Pharmacological agents and compounds targeting caspase-7
3.2.2 Therapeutic implications of caspase-7 activators
3.2.2.1 Ischemia
3.2.2.2 Ischemia/reperfusion injury
3.2.2.3 Cancer
4. Clinical relevance and potential therapeutic strategies
5. Conclusion
References
7
Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy
1. Introduction
2. Pharmacology of caspase-8
3. Caspase-8 overexpression induces cell death
3.1 Apoptosis
3.2 Role of caspase-8 and caspase-10 in apoptosis
3.3 Activation of caspase-8 and caspase-10
3.4 Initiating apoptotic signaling
3.5 Cross-talk with other pathways
4. Overview of apoptosis and its dysregulation in cancer
5. Dysregulation in diseases
5.1 Immunodeficiency and autoimmune disorders
5.2 Cancers
5.2.1 Breast cancer
5.2.2 Colorectal cancer
5.2.3 Prostate cancer
5.2.4 Ovarian cancer
5.2.5 Tongue squamous carcinoma
5.2.6 Bladder cancer
5.2.7 Glioblastoma
5.2.8 Renal cell cancer
5.2.9 Lung cancer
5.2.10 Liver cancer/hepatocellular carcinoma
5.2.11 Pediatric tumors
5.2.12 Human neuroblastoma
5.2.13 Neurodegenerative diseases
6. Significance of caspase-8 and caspase-10 dysregulation in cancer progression
7. Molecular mechanisms of caspase-8 and caspase-10 dysregulation in cancer.