rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Caspases as molecular targets for cancer therapy
  name:
    name part: Vaidya, Ankur
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    date issued: 2024
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases.It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities.
  table of contents: Front Cover -- CASPASES AS MOLECULAR TARGETS FOR CANCER THERAPY -- CASPASES AS MOLECULAR TARGETS FOR CANCER THERAPY -- Copyright -- Dedication -- Contents -- Contributors -- About the editor -- Preface -- 1 -- Introduction to caspases, its function, mechanism, and classification -- 1. Introduction -- 2. Caspases -- 2.1 Molecular structure -- 2.2 Functions -- 2.2.1 Caspase's role in apoptosis -- 2.2.2 Caspases in the regulation of the JAK/STAT signaling pathway -- 2.2.3 Caspases as inflammatory mediators -- 2.2.4 Caspases in neurogenesis -- 2.2.5 Caspases signaling in excitotoxicity -- 2.3 Mechanism of activation -- 2.3.1 Intrinsic pathway -- 2.3.2 Extrinsic pathway -- 2.4 Classification of caspases -- 2.4.1 Caspase-1 -- 2.4.2 Caspase-2 -- 2.4.3 Caspase-3 -- 2.4.4 Caspase-4 -- 2.4.5 Caspase-5 -- 2.4.6 Caspase-6 -- 2.4.7 Caspase-7 -- 2.4.8 Caspase-8 -- 2.4.9 Caspase-9 -- 2.4.10 Caspase-10 -- 2.4.11 Caspase-11 -- 2.4.12 Caspase-12 -- 2.4.13 Caspase-13 -- 2.4.14 Caspase-14 -- 3. Conclusions -- References -- 2 -- Mutations within apoptosis gene and caspases -- 1. Introduction -- 1.1 What is apoptosis? -- 1.2 Importance of apoptosis in cell regulation -- 1.3 Role of apoptosis genes and caspases in the apoptotic pathway -- 2. Understanding apoptosis genes -- 2.1 Key apoptosis genes and their functions -- 2.2 Impact of mutations on apoptosis genes -- 2.3 Techniques for identifying apoptosis gene mutations -- 2.3.1 Electron microscopy -- 2.3.2 Proteomic and genomic methods -- 2.3.3 Spectroscopic techniques -- 2.3.4 Flow cytometry -- 2.3.5 Detection of the apoptosis using the immunological technique -- 3. Caspases: The executioners of apoptosis -- 3.1 Caspase family overview -- 3.2 Activation and regulation of caspases -- 3.2.1 Caspase activation by cell surface death receptors -- 3.2.2 Caspase activation by mitochondrial pathway.
  table of contents: 4. Diseases associated with apoptosis gene and caspase mutations -- 4.1 Cancer and apoptosis gene mutations -- 4.1.1 Carcinogenesis via intrinsic signaling defects -- 4.1.2 Carcinogenesis via extrinsic pathway signaling defect -- 4.2 Neurodegenerative disorders and caspase mutation -- 4.3 Other genetic diseases linked to apoptotic dysregulation -- 5. Clinical implications and therapeutic opportunities -- 5.1 Diagnostic and prognostic applications of apoptosis gene mutations -- 5.2 Targeting apoptosis for therapeutic interventions -- 6. Conclusion and future perspectives -- References -- 3 -- Inflammatory caspase-1, -4, and -5 and their role in anticancer activity -- 1. Introduction -- 1.1 Caspase-1, -4, and 5 -- 1.1.1 Structural features of caspase-1, -4, and -5 -- 1.1.2 Types of caspases based on their function and activation mechanism -- 1.2 Overview of their role in the inflammatory response -- 1.3 Overview of their potential role in cancer therapy -- 1.4 Inflammasome -- 1.5 Protective roles of inflammasomes in cancer -- 1.6 Pharmacological inhibition of NLRP3 inflammasome -- 2. Synthetic caspase inhibitors -- 2.1 Peptide-based inhibitors -- 2.2 Peptidomimetic inhibitors -- 2.2.1 Fluoromethyl ketones -- 2.2.2 Nitriles -- 2.2.3 Triazoles -- 2.2.4 Triazines -- 2.3 Nonpeptidic compounds -- 2.4 Allosteric caspase inhibitors -- 2.5 Natural inhibitors -- 2.5.1 Macromolecular inhibitors -- 2.5.2 Serpins -- 2.5.3 X-linked inhibitor of apoptosis protein -- 2.5.4 Recombinant proteins -- 2.6 Dual inhibitors -- 2.7 Miscellaneous -- 2.8 Conclusion -- References -- 4 -- Caspase-2 and tumor suppression -- 1. Introduction -- 2. Anticancer connection of caspase-2 -- 3. Structural features of caspase-2 regarding its activation and processing -- 3.1 Caspase recruitment initiation complex-dependent proximity-induced dimerization and conformation.
  table of contents: 2.2.5 Neurological implications -- 2.3 Effects of caspase-7 activators on cellular responses and disease outcomes -- 3. Activators of caspase-7 -- 3.1 Overview of endogenous activators of caspase-7 -- 3.1.1 Identification and characterization of natural activators -- 3.1.2 Regulatory mechanisms governing caspase-7 activation -- 3.1.2.1 Extrinsic and intrinsic cell death -- 3.1.2.2 Activation of caspases in differentiation -- 3.2 Exogenous activators and their impact on caspase-7 activation -- 3.2.1 Pharmacological agents and compounds targeting caspase-7 -- 3.2.2 Therapeutic implications of caspase-7 activators -- 3.2.2.1 Ischemia -- 3.2.2.2 Ischemia/reperfusion injury -- 3.2.2.3 Cancer -- 4. Clinical relevance and potential therapeutic strategies -- 5. Conclusion -- References -- 7 -- Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy -- 1. Introduction -- 2. Pharmacology of caspase-8 -- 3. Caspase-8 overexpression induces cell death -- 3.1 Apoptosis -- 3.2 Role of caspase-8 and caspase-10 in apoptosis -- 3.3 Activation of caspase-8 and caspase-10 -- 3.4 Initiating apoptotic signaling -- 3.5 Cross-talk with other pathways -- 4. Overview of apoptosis and its dysregulation in cancer -- 5. Dysregulation in diseases -- 5.1 Immunodeficiency and autoimmune disorders -- 5.2 Cancers -- 5.2.1 Breast cancer -- 5.2.2 Colorectal cancer -- 5.2.3 Prostate cancer -- 5.2.4 Ovarian cancer -- 5.2.5 Tongue squamous carcinoma -- 5.2.6 Bladder cancer -- 5.2.7 Glioblastoma -- 5.2.8 Renal cell cancer -- 5.2.9 Lung cancer -- 5.2.10 Liver cancer/hepatocellular carcinoma -- 5.2.11 Pediatric tumors -- 5.2.12 Human neuroblastoma -- 5.2.13 Neurodegenerative diseases -- 6. Significance of caspase-8 and caspase-10 dysregulation in cancer progression -- 7. Molecular mechanisms of caspase-8 and caspase-10 dysregulation in cancer.
  note: edited by Ankur Vaidya.
  note: Includes bibliographical references and index.
  subject:
    topic: Cancer
    topic: Chemotherapy
  subject:
    topic: Cancer
    topic: Treatment
  subject:
    topic: Cancer
    topic: Chimiothérapie
  subject:
    topic: Cancer
    topic: Traitement
  classification: RC271.C5 C37 2024
  classification: 616.99/4061
  related item:
    identifier: (OCoLC)1427657350
  identifier: 9780443156458
  identifier: 044315645X
  identifier: 9780443156441
  identifier: 0443156441
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: YDX
    record creation date: 240815
    record change date: 20260327180327.6
    record identifier: in00005773652
    language of cataloging:
      language term: eng