Neuropsychological and psychosocial foundations of neuro-oncology /
Neuropsychological & Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues, Chapters discuss primary CNS tumors, brain metastases, leptomenin...
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| Format: | eBook |
| Language: | English |
| Published: |
London :
Academic Press,
2024.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- Neuropsychological and Psychosocial Foundations of Neuro-Oncology
- Copyright
- Dedication
- Contents
- Contributors
- About the editors
- Preface
- Section I: Neuropsychological foundations of neuro-oncology
- Chapter 1: History of neuro-oncology and neuropsychology
- Introduction
- History of neuro-oncology
- History of neuropsychology
- References
- Chapter 2: Neurocognitive functioning: From brain structures to networks
- Introduction
- Short historical background
- Neurocognitive domains
- Primary functions: Visual, auditory perception, and sensorimotor function
- Higher order neurocognitive functions
- Information processing speed
- Attention
- Memory
- Executive functioning
- Motor and action
- Social cognition
- Language
- A network approach
- Short historical background and introduction into network theory
- Network neuroscience
- Measuring networks in humans
- Individual differences and variability
- Conclusion
- References
- Chapter 3: Taking a therapeutic and biopsychosocial approach to the neuropsychological interview for assessment of brain ...
- Introduction
- Assessment models in neuropsychology
- Informed consent as an ongoing process
- Biopsychosocial model in the neuropsychological assessment of primary brain tumor patients
- Assessment domains
- Cognitive symptoms
- Psychosocial distress: Mood, anxiety, trauma
- Sleep and fatigue
- Social functioning and support
- Identity changes
- Work and disability
- Sexual health and intimacy
- Caregiver burden
- Final thoughts
- References
- Chapter 4: Neuropsychological assessment in neuro-oncology
- Introduction
- Foundations of objective neuropsychological assessment
- Neuropsychological assessment in neuro-oncology
- Prerequisites to neuropsychological assessment
- Neurocognitive domains and the tests that measure them.
- Interpretation of neuropsychological findings
- Guidlines for objective neuropsychological assessment in neuro-oncology
- Objective neuropsychological assessment in clinical trials
- Future directions
- Conclusions
- References
- Chapter 5: Patient-reported assessment: Identifying cognitive concerns in brain tumor patients
- Definitions and incidence
- Subjective cognitive function
- Clinical practice implementation
- Subjective cognitive function measurement
- Instruments for initial screening
- Subjective cognitive function instruments
- Association with objective neuropsychological assessments
- Implications for practice
- References
- Chapter 6: Quality of life and patient-reported outcomes in neuro-oncology clinical care and research
- Introduction
- Quality of life in neuro-oncology
- Determinants of QoL
- Tumor and treatment-related factors
- Symptom burden and functional limitations
- Socioeconomic factors
- Social support
- Quality of life measurement approaches
- Multidimensional PROMs
- EORTC QLQ-C30
- EORTC QLQ-BN20
- FACT-Br
- SF-36
- Unidimensional PROMs
- Symptom burden and interference
- MDASI-BT
- ESAS
- BFI
- Mood
- Distress thermometer
- POMS
- HADS
- PROMIS anxiety and depression
- BDI and BAI
- STAI
- Cognitive function
- Neuro-QoL
- MOS-COG-R
- FACT-Cog
- Sleep
- PSQI
- ISI
- ESS
- PROMIS SD and SRI
- Physical function and performance status
- PROMIS physical function
- Barthel Index
- Preliminary EORTC IADL-BN
- Financial toxicity
- COST-FACIT
- Applications of PROMs in neuro-oncology
- Personalized care and shared decision-making
- Treatment selection and evaluation
- Long-term monitoring and survivorship care
- Supportive and palliative care
- Prognostication
- Research and comparative effectiveness
- Population health and policy.
- Modern approaches to capture PROs in neuro-oncology
- Electronic patient-reported outcome (ePRO) platforms
- Wearable devices and sensors
- Telehealth and remote monitoring
- Integration with electronic health records (EHRs)
- Future directions for PROs in neuro-oncology
- Personalized patient care
- Longitudinal monitoring
- Shared decision-making
- Research and clinical trials
- Integration with electronic health records (EHRs)
- Harnessing artificial intelligence (AI)
- Conclusion
- References
- Section II: Effects of neuro-oncology and systemic treatment on cognitive functioning
- Chapter 7: Imaging in neuro-oncology
- Introduction
- Gliomas
- Adult-type diffuse gliomas
- Astrocytoma, IDH-mutant
- Oligodendroglioma, IDH-mutant and 1p/19q co-deleted
- Glioblastoma, IDH-wild type
- Pediatric-type diffuse low-grade gliomas
- Diffuse astrocytomas, MYB or MYBL1-altered
- Angiocentric glioma
- Polymorphous low-grade neuroepithelial tumor of the young (PLNTY)
- Diffuse low-grade gliomas, MAPK pathway altered
- Pediatric-type diffuse high-grade gliomas
- Diffuse midline glioma, H3K27-altered
- Diffuse hemispheric glioma, H3 G34-mutant
- Diffuse pediatric type high-grade glioma, H3-wildtype, and IDH-wildtype
- Infant-type hemispheric glioma
- Circumscribed astrocytic gliomas
- Pilocytic astrocytoma
- High-grade astrocytomas with piloid features
- Pleomorphic xanthoastrocytoma
- Subependymal giant cell astrocytoma
- Chordoid glioma
- Astroblastoma, MN1-altered
- Neuronal and glioneuronal tumors
- Ganglioglioma
- Dysembryoplastic neuroepithelial tumor (DNET)
- Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG)
- Dysplastic cerebellar gangliocytoma
- Multinodular and vacuolating neuronal tumor (MVNT)
- CNS lymphoma
- Extra-axial tumors
- Tumors of the meninges
- Tumors of the cranial nerves.
- Intraventricular neoplasms
- Pineal region neoplasms
- Sellar and suprasellar neoplasms
- Metastatic disease
- References
- Chapter 8: Pathology and treatment of primary and metastatic brain tumors
- Pathology and treatment of primary brain tumors
- Pathology of primary brain tumors
- Surgical therapy of primary brain tumors
- Radiation therapy of primary brain tumors
- Chemotherapy of primary brain tumors
- Molecular or ``targeted´´ treatment
- Tumor-treating fields
- Pathology and treatment of metastatic brain tumors
- Pathology of metastatic brain tumors
- Surgical therapy of metastatic brain tumors
- Radiation therapy of metastatic brain tumors
- Chemotherapy of metastatic brain tumors
- References
- Chapter 9: Overview of systemic treatment and toxicity in cancer patients
- Introduction
- Primary central nervous system tumors
- Breast cancer
- Prostate cancer
- Lung cancer
- Colorectal cancer
- Cutaneous melanoma
- Non-Hodgkin lymphoma
- Leukemia
- Myeloma
- Summary
- References
- Chapter 10: Delirium and mental status changes in neuro-oncology
- Introduction
- Delirium due to brain lesion
- Delirium due to local treatment
- Postoperative delirium
- Radiotherapy
- Delirium due to medication
- Chemotherapy
- Seizure medication
- Corticosteroids
- Supportive care
- Delirium due to complications of disease or treatment
- Infections
- Seizures
- Metabolic/hormonal complications
- Management of delirium
- References
- Chapter 11: The neuropsychological impact of surgical intervention and utility of awake craniotomies
- Introduction
- Tools to define neurocognition in awake craniotomy patients
- Anatomical basis of cognitive function in disease states indicating awake craniotomies
- Awake brain mapping craniotomy
- Indications and contraindications
- Intraoperative assessment of cognition.
- Anatomical basis of brain mapping
- Mapping technique
- Mapping outcomes
- References
- Chapter 12: Neuropsychological implications of radiotherapy
- Introduction
- Pathophysiology
- Neurocognitive and psychologic assessment and guidelines
- Risk factors for psychosocial disorders
- Radiation dosimetry and neuropsychological consequences
- Treatment
- Depression and anxiety
- Adjustment disorder (AD)
- Posttraumatic stress disorder (PTSD)
- Neurobehavioral impairment in pediatric brain tumor survivors
- Conclusion
- References
- Chapter 13: Neuropsychological manifestations of chemotherapy
- CRCI-Risk factors
- Natural aging
- Genetic predisposition
- Miscellaneous
- CRCI-Pathogenesis
- Immune dysregulation, inflammatory response, and cytokines release
- Altered hormonal homeostasis
- Blood-brain barrier permeability and CRCI risk
- Oxidative stress and DNA damage
- Neurovascular features of CRCI
- Neurostructural features of CRCI
- Neuroimaging features of CRCI
- Electrophysiologic features of CRCI
- Neuropathological features of CRCI
- Psychiatric features of CRCI
- Neuropsychological assessment of CRCI
- Cognitive domains at risk
- Neuropsychological testing considerations
- Socioeconomic toxicity of cancer and cancer therapy
- CRCI-Treatment and prevention
- Future directions
- References
- Chapter 14: Neuropsychological issues related to immunotherapy
- Introduction
- Epidemiology and pathophysiology
- CNS immune-related adverse events from immune checkpoint inhibitors
- CNS immune-mediated events from CAR T-cells
- Encephalitis
- Aseptic meningitis
- Hypophysitis
- Other ICI-associated CNS immune-related adverse events
- CAR T-cell-mediated neurotoxicity: Immune effector cell-associated neurotoxicity syndrome (ICANS)
- Conclusion
- References.