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Food-borne delivery systems of functional substances for precision nutrition
Food-Borne Delivery Systems of Functional Substances for Precision Nutrition, Volume 112 highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Biological activity, limitations, and steady-state delivery of functional substances for precision nutrition, Nanoparticles delivery systems of functional substances for precision nutrition, Micelles delivery systems of functional substances for precision nutrition, Microgel delivery systems of functional substances for precision nutrition, Emulsions delivery systems of functional substances for precision nutrition, and Microencapsule delivery systems of functional substances for precision nutrition, and much more. Other chapters focus on Liposomes' delivery systems of functional substances for precision nutrition, Hydrogel delivery systems of functional substances for precision nutrition, Vesicle delivery systems of functional substances for precision nutrition, and Future development trend of food-borne delivery systems of functional substances for precision nutrition.
Front Cover -- Series Page -- Advances in Food and Nutrition Research -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Biological activity, limitations and steady-state delivery of functional substances for precision nutrition -- 1 Introduction and classification of functional substances -- 2 Challenges of functional substances in precision nutrition -- 2.1 Factors impacting the stability of functional substances -- 2.1.1 Light -- 2.1.2 Oxygen -- 2.1.3 Temperature -- 2.1.4 pH -- 2.1.5 Metal ions -- 2.1.6 Solubility -- 2.2 Bioavailability -- 2.2.1 Strong acidic environment in the gastric cavity -- 2.2.2 Enzyme metabolism in the gastrointestinal tract -- 2.2.3 Food matrix -- 2.2.4 Changes in the structure and permeability of delivery systems -- 2.2.5 Physiological barrier of mucous layer -- 3 Current status of delivery systems of functional substances -- 3.1 Design of stability encapsulation methods and construction of delivery system for functional substances -- 3.2 Targeted controlled release of functional substances -- 3.2.1 pH-responsive drug delivery system -- 3.2.2 Enzyme responsive release delivery system -- 3.2.3 Redox response release delivery system -- 3.2.4 Targeted delivery system -- 4 Desirable characteristics of functional substance delivery systems -- 4.1 Food grade status -- 4.2 High loading capacity -- 4.3 Targeting -- 4.4 Controlled release capacity -- 4.4.1 pH-response release -- 4.4.2 ROS-response release -- 4.4.3 GSH-response release -- 5 Applications of food-borne delivery systems for precise nutrient delivery -- 5.1 Passive targeting -- 5.2 Active targeting -- 5.2.1 Receptor targeting -- 5.2.2 Stimulus responsive targeted -- 5.2.3 Gastrointestinal tract cell targeting -- 5.2.4 Other tissue and organ targeting -- 5.2.5 Targeting specific organelles -- Acknowledgements -- References.
Chapter Two: Nanoparticle delivery systems of functional substances for precision nutrition -- 1 Introduction -- 2 Design and preparation of nanoparticle delivery systems for functional substances -- 2.1 Bioactive polysaccharides -- 2.2 Bioactive proteins and peptides -- 2.3 Polyunsaturated fatty acid -- 2.4 Vitamins -- 2.5 Probiotics -- 2.6 Enzymes -- 2.7 Phytochemicals -- 3 Application of nanoparticle delivery systems in nutritional intervention -- 3.1 Environmental stimuli-responsive delivery systems -- 3.1.1 pH-responsive delivery systems -- 3.1.1.1 Enzyme-responsive delivery systems -- 3.1.1.2 Mucoadhesive and mucus-penetrating delivery systems -- 3.2 Site-specific delivery systems -- 3.3 Delivery systems for diseases intervention -- 3.3.1 Obesity -- 3.3.2 Inflammatory bowel disease -- 3.3.3 Liver disease -- 3.3.4 Tumors and cancer -- 4 Conclusions -- References -- Chapter Three: Micellar delivery systems of bioactive compounds for precision nutrition -- 1 Introduction -- 2 Background of micelles -- 2.1 Preparation methods of micelles -- 2.1.1 Dialysis method -- 2.1.2 Direct dissolution method -- 2.1.3 Solvent evaporation method -- 2.1.4 Thin-film hydration method -- 2.1.5 Ultrasonication -- 2.1.6 pH cycling method -- 2.1.7 Other methods -- 2.2 Fundamental characteristics of polymeric micelles -- 2.2.1 Particle size and shape of polymeric micelles -- 2.2.2 Surface charge of polymeric micelles -- 3 Major polymeric micelles and customized strategies for improving their properties -- 3.1 Polymeric micellar delivery systems -- 3.1.1 Protein-based micelles -- 3.1.1.1 Casein-based micelles -- 3.1.1.2 Whey protein-based micelles -- 3.1.2 Polysaccharide-based micelles -- 3.1.2.1 Chitosan-based micelles -- 3.1.2.2 Starch-based micelles -- 3.1.2.3 Dextran-based micelles -- 3.1.2.4 Curdlan-based micelles -- 3.1.2.5 Other polysaccharides-based micelles.
3.1.3 Other polymeric-basic micelles -- 3.2 Customized strategies for modifying polymeric micelle properties -- 3.2.1 Changing internal properties -- 3.2.1.1 Enzyme cross-linking -- 3.2.1.2 Glycosylation modification -- 3.2.1.3 Moderate enzymolysis -- 3.2.1.4 Octenyl succinic anhydride (OSA) modification -- 3.2.2 Changing medium environment -- 3.2.2.1 pH variations -- 3.2.2.2 Temperature variations -- 3.2.2.3 Ultrasonication -- 3.2.2.4 High hydrostatic pressure (HHP) treatment -- 4 Polymeric micelles for delivering bioactives -- 4.1 Polymeric micellar carriers for carotenoids -- 4.2 Polymeric micellar carriers for polyphenols -- 4.3 Polymeric micellar carriers for vitamins -- 4.4 Polymeric micellar carriers for other bioactives -- 5 Micellar carriers for precision nutrition -- 5.1 Targeted-release of bioactives -- 5.2 Organ-targeted ability of bioactives -- 5.3 Cell uptake promotion of bioactives -- 5.4 Application in nutritional intervention of chronic diseases -- 5.4.1 Inflammatory bowel disease -- 5.4.2 Obesity -- 5.4.3 Cancer -- 5.4.4 Liver diseases -- 6 Conclusions -- References -- Chapter Four: Microgel delivery systems of functional substances for precision nutrition -- 1 Introduction -- 2 Biopolymers for the preparation of microgel -- 2.1 Polysaccharide -- 2.2 Protein -- 3 Microgel fabrication strategies and methods -- 3.1 The "top-down" route -- 3.2 The "bottom-top" route -- 3.3 Other preparation routes -- 4 Characteristics and functions of microgel delivery system -- 4.1 Characteristics of microgel delivery system -- 4.2 High encapsulation of microgel delivery system -- 4.3 Responsive-release function of microgel delivery system -- 4.4 Targeting function of microgel delivery system -- 4.5 Good bioaccessibility and absorption of microgel delivery system -- 5 Microgel delivery system for precision nutrition.
4.1 Controlling gastrointestinal fate of bioactive components -- 4.1.1 Mouth -- 4.1.2 Stomach -- 4.1.3 Small intestine -- 4.1.4 Colon -- 4.2 Application of microcapsule delivery systems in chronic disease intervention -- 4.2.1 Nutritional intervention on inflammatory bowel disease -- 4.2.2 Nutritional intervention on alcoholic/nonalcoholic fatty liver disease -- 4.2.3 Nutritional intervention on diabetes -- 4.2.4 Nutritional intervention on cancer -- 5 Conclusions -- References -- Chapter Seven: Liposomes delivery systems of functional substances for precision nutrition -- 1 Introduction -- 2 Designing and modification of liposomes -- 2.1 Natural and synthetic liposomes -- 2.2 Surface modification of liposomes -- 2.2.1 The evolution of liposomes -- 2.2.2 PEG-modified liposomes -- 2.2.3 Targeted liposomes -- 2.3 Specific modalities of liposome surface modification -- 2.3.1 Liposomes modified by polymers -- 2.3.2 Liposomes modified with nanoparticles -- 2.3.3 Liposomes modified with functional groups -- 3 Application status of liposomes in functional substances -- 3.1 Preparation method of food-grade liposomes -- 3.1.1 Conventional preparation methods of food-grade liposomes -- 3.1.1.1 Mechanical dispersion method -- 3.1.1.2 Thin film dispersion method -- 3.1.1.3 Detergent removal method -- 3.1.1.4 Solvent injection method -- 3.1.1.5 Reverse phase evaporation method -- 3.1.1.6 Calcium fusion method -- 3.1.2 Novel methods -- 3.1.2.1 Supercritical fluid method -- 3.1.2.2 Dynamic high pressure microfluidization method -- 3.1.2.3 Membrane contactor-based method -- 3.1.2.4 Freeze-drying double emulsions -- 3.1.2.5 Other methods -- 3.2 Loading and encapsulation of nutrients -- 3.2.1 Passive loading -- 3.2.2 Active loading -- 3.3 Applications of nutrient-loaded liposomes in the food industry -- 3.3.1 Loading enzyme preparations.
Advances in food and nutrition research ; volume 112
Advances in food and nutrition research ; v. 112