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Macrophages biology and tissue inflammation in health and disease /

This book explores the biology of macrophages and their role in inflammation, tissue repair, and regeneration. It provides an in-depth analysis of the cellular and molecular mechanisms of inflammation, distinguishing between acute and chronic types. The text also examines the interaction between mac...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Goodman, Stuart B., Takagi, Michiaki, Gallo, Jiri
Format: eBook
Language:English
Published: London : Academic Press, 2024.
Subjects:
Macrophages.
Inflammation > Immunological aspects.
Inflammation (Pathologie) > Immunologie.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Macrophages Biology and Tissue Inflammation in Health and Disease
  • Copyright
  • Contents
  • Contributors
  • Chapter 1: Inflammation and macrophage development
  • 1. Inflammation
  • 2. Local immune response
  • 3. Role of macrophages in inflammation, tissue repair, and regeneration
  • 4. Macrophage development
  • 5. Macrophages populations
  • 6. Tissue-resident macrophages
  • References
  • Chapter 2: Acute and chronic inflammation
  • 1. General features of inflammation
  • 2. Proinflammatory threats
  • 3. Acute inflammation
  • 4. Chronic inflammation
  • 5. New insights of TRMs in inflammation
  • 6. Systemic effect of inflammation
  • References
  • Chapter 3: Phenotype and function of macrophages is regulated by chemokines
  • 1. Chemokines
  • 2. Chemokines and their receptors in macrophages
  • 2.1. Macrophage plasticity and heterogeneity
  • 2.1.1. Heterogeneity of macrophages
  • 2.1.2. Plasticity of macrophages
  • 3. Chemokines in homeostasis and inflammation
  • 4. Chemokines in diseases of the musculoskeletal system
  • 4.1. Chemokines in bone remodeling
  • 4.2. Chemokines in osteoporosis
  • 4.3. Chemokines mediating pathologic response to orthopedic implants
  • 4.4. Chemokines in osteoarthritis
  • 4.5. Chemokines in rheumatoid arthritis
  • 5. Chemokines in the therapy
  • References
  • Chapter 4: Cross talk between macrophages and other cells
  • 1. Introduction
  • 2. How does cellular cross talk occur?
  • 2.1. Macrophages and cell-to-cell contact
  • 2.2. Macrophage communication via soluble factors
  • 2.3. Extracellular vesicles, exosomes, and microvesicles
  • 2.4. Macrophage extracellular traps (METs)
  • 3. Discussion
  • 3.1. Where we are now
  • 3.2. Opportunities
  • 4. Conclusion
  • Acknowledgments
  • References
  • Chapter 5: Macrophages in tissue engineering and regeneration.
  • 1. Macrophage polarization: From inflammation to regeneration
  • 2. Mesenchymal stem cell-macrophage cross talk
  • 2.1. Macrophage production of growth factors
  • 3. Regeneration
  • 3.1. Bone
  • 3.2. Skeletal muscle
  • 3.3. Skin
  • 4. Regeneration vs. fibrosis
  • 5. Macrophages in tissue engineering
  • 5.1. Bone
  • 5.2. Skin
  • 5.3. Treatment of inflammatory dysregulation/chronic inflammation
  • 6. Conclusion
  • References
  • Chapter 6: Macrophages and the musculoskeletal system
  • 1. Introduction
  • 2. Tissue-specific macrophages in healthy musculoskeletal tissues
  • 3. Synovial macrophages and joint fluid production
  • 3.1. Synovium
  • 3.2. Joint fluid production
  • 3.3. Joint fluid workup
  • 4. Macrophages in inflammatory musculoskeletal diseases
  • 4.1. Rheumatoid arthritis
  • 4.2. Seronegative spondyloarthritis
  • 4.3. Psoriatic arthritis
  • 4.4. Reactive arthritis
  • 5. Macrophages in noninflammatory musculoskeletal diseases
  • 5.1. Osteoarthritis (OA)
  • 5.2. Macrophages in the intervertebral disc pathology
  • 5.3. Macrophages in tendinopathy and tendinitis
  • 5.4. Macrophages in enthesopathy
  • 5.5. Macrophages in the healing of traumatic injuries
  • 5.6. Macrophages in osteoporosis
  • 6. Macrophages in biomaterial-associated complications
  • 6.1. Macrophages around stable total joint arthroplasty
  • 6.2. Macrophages in aseptic loosening/periprosthetic osteolysis
  • 6.3. Macrophages in prosthetic joint infection
  • 7. Macrophages in orthopedic infections
  • 7.1. Osteomyelitis, spondylodiscitis
  • 7.2. Septic arthritis
  • 8. Macrophages in musculoskeletal tumors
  • 8.1. Tumor microenvironment (TME) concept
  • 8.2. Tumor-associated macrophages
  • 8.3. Role of macrophages in metastasis
  • 8.4. Why bone and not skeletal muscle is preferential metastatic site?
  • 9. Macrophages in aging MS system
  • 9.1. Multiple myeloma.
  • 9.2. Sarcopenia-Skeletal muscle aging and macrophages
  • 9.3. Musculoskeletal stiffness and inflammaging
  • 9.4. Can aging be slowed via affecting the macrophages?
  • 10. Conclusion
  • Acknowledgments
  • References
  • Chapter 7: Future research and applications
  • 1. Introduction
  • 2. Macrophage-assisted immunomodulation
  • 3. Macrophage-assisted tissue healing, regeneration, or substitution
  • 4. Macrophage-assisted strategies for maintenance of healthy implant-tissue interfaces
  • 5. Macrophage-assisted antiinfective approaches
  • 6. Macrophage-assisted antiaging and resilience strategies
  • 7. Bioinformatic approaches to estimation of macrophage behavior
  • 8. Conclusion
  • Acknowledgment
  • References
  • Chapter 8: Conclusion
  • Index.