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Mechanics in development and disease /

This book, 'Mechanics in Development and Disease,' edited by Celeste M. Nelson and Lance A. Davidson, explores the role of mechanical forces in developmental biology and disease. It provides in-depth insights into the mechanics underlying the development of various biological systems, incl...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Nelson, Celeste M. (Editor), Davidson, Lance A. (Editor)
Format: eBook
Language:English
Published: London : Academic Press, an imprint of Elsevier, 2024.
Edition:First edtion.
Series:Current topics in developmental biology ; v. 160.
Subjects:
Biomechanics.
Biophysics.
Biomécanique.
Biophysique.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Series Page
  • Current Topics in Developmental Biology
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Salivary gland developmental mechanics
  • 1 Introduction
  • 1.1 Structure and function of the salivary gland
  • 1.2 Morphogenesis overview of the salivary gland
  • 1.3 Cell differentiation in salivary gland development
  • 1.4 Mechanics of salivary gland development
  • 2 Epithelial cell mechanics in salivary gland morphogenesis
  • 2.1 Epithelial cell adhesions
  • 2.2 Contribution of epithelial cell adhesion to morphogenesis
  • 2.3 Cell proliferation in salivary gland morphogenesis
  • 2.4 Epithelial cell motility in salivary gland morphogenesis
  • 2.5 Actomyosin contractility
  • 3 Basement membrane mechanics in salivary gland morphogenesis
  • 3.1 Basement membrane in the salivary gland
  • 3.2 Adhesion between epithelial cells and the basement membrane
  • 3.3 Patterned mechanical constraint by the basement membrane
  • 4 Mechanical contributions by the mesenchyme
  • 4.1 The mesenchyme of embryonic salivary gland
  • 4.2 Mechanical properties of the mesenchyme
  • 4.3 Mechanical constraint by the mesenchyme
  • 5 Concluding remarks
  • References
  • Chapter Two: The fusion of physics and biology in early mammalian embryogenesis
  • 1 Introduction to early mammalian embryogenesis: from blastulation to gastrulation
  • 2 Blastulation
  • 2.1 Morula compaction and polarization
  • 2.2 Cavitation
  • 2.3 ICM sorting
  • 3 Implantation
  • 3.1 Biomechanics at the endometrium-trophoblast interface
  • 3.2 Peri-implantation epiblast development
  • 4 Gastrulation
  • 4.1 Germ layer specification and establishment of the body axes
  • 5 Outlook on the future of biomechanics in embryogenesis: a role for embryo models
  • Acknowledgment
  • References
  • Chapter Three: Biophysics of morphogenesis in the vertebrate lung.
  • 1 Introduction to the functional anatomy of the vertebrate lung
  • 1.1 Bronchoalveolar lung of mammals
  • 1.2 Parabronchial lung of birds
  • 1.3 Faveolar lung of reptiles
  • 2 Biophysics of branch initiation in the mammalian lung
  • 2.1 Epithelial tissue structure during branch initiation
  • 2.2 Physical forces from airway smooth muscle differentiation
  • 2.3 Physical properties of ECM and pulmonary mesenchyme
  • 2.4 Fluid pressure and downstream signaling
  • 3 Active folding during branch initiation in the avian lung
  • 3.1 Epithelial tissue structure during branch initiation
  • 3.2 Physical properties of the ECM and pulmonary mesenchyme
  • 4 Pressure-driven expansion of the epithelium in the lizard lung
  • 4.1 Epithelial tissue structure during formation of faveoli
  • 4.2 Morphogenesis of the pulmonary mesenchyme-building a rigid mesh
  • 4.3 Fluid pressure and downstream signaling
  • 4.4 Similarities to alveologenesis in the mammalian lung
  • 5 Conceptual framework-mesenchyme is the architect
  • 5.1 Material properties of the epithelium-what's the parameter space?
  • 5.2 Softening or stiffening of the mesenchyme-how is pattern controlled?
  • 5.3 The connections between biochemical signaling and tissue mechanics
  • 6 Conclusions and outlook
  • Acknowledgments
  • References
  • Chapter Four: Gears of life: A primer on the simple machines that shape the embryo
  • 1 Self-assembly and morphogenesis
  • 1.1 The embryo as a machine
  • 1.2 The gears of morphogenesis
  • 2 Mechanical principles of morphogenesis
  • 2.1 Morphogenesis requires wet cells and tissues carry out physical work
  • 2.2 Materials and structures
  • 2.3 Biopolymers
  • 2.4 From solid-like elasticity to fluid-like viscosity, and all points in between
  • 2.5 The labors of the embryo: force generation, transmission, and dissipation
  • 3 Simple machines
  • 3.1 Epithelial and mesenchymal sheets.
  • 3.2 Thinning, thickening, or multilayering through cell shape change, division, extrusion, and radial intercalation
  • 3.3 Traction, tethers, and anchors
  • 4 Understanding morphogenesis through models
  • 4.1 Build-a-model
  • 4.2 Biomechanical testing
  • 4.3 The value of simple models and biomechanical analysis
  • 5 Lessons from embryonic and cell culture models
  • 5.1 Coordination within and between cell multiple layers
  • 5.2 Embryos are unlikely places to find single isolated migratory cells
  • 5.3 Diversity in epithelial material properties exposed in "epithelial bridges"
  • 6 Supracellular movements
  • 6.1 Blastopore closure in Xenopus
  • 6.2 Dorsal closure in Drosophila
  • 6.3 Open problems in supracellular self-assembly
  • 7 Conclusion
  • Acknowledgments
  • References
  • Back Cover.