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Biochemical and molecular pharmacology in drug discovery /

This comprehensive book, 'Biochemical and Molecular Pharmacology in Drug Discovery,' edited by Mithun Rudrapal, Chukwuebuka Egbuna, and William C. C Ho, provides an in-depth exploration of the biochemical and molecular aspects critical to the process of drug discovery. It covers a wide arr...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: [S.l.] : Elsevier, 2024.
Series:Drug Discovery Update Series.
Subjects:
Pharmacology.
Molecular pharmacology.
Pharmacology
Pharmacologie.
Pharmacologie moléculaire.
pharmacology.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY
  • BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY
  • Copyright
  • Contents
  • Contributors
  • I
  • Biochemical and molecular aspects
  • 1
  • Structures and functions of biomolecules
  • 1. Introduction
  • 1.1 About biomolecules
  • 1.2 Carbohydrates
  • 1.2.1 Structure of carbohydrates
  • 1.2.2 Functions of carbohydrates
  • 1.3 Proteins
  • 1.3.1 Structure of proteins
  • 1.3.2 Functions of proteins
  • 1.4 Lipids
  • 1.4.1 Structure of lipids
  • 1.4.2 Functions of lipids
  • 1.5 Nucleic acids
  • 1.5.1 Structure of nucleic acids
  • 1.5.1.1 Types of RNA
  • 1.5.2 Functions of nucleic acids
  • 2. Structure Activity Relationship (SAR)
  • 2.1 Need for the SAR study
  • 3. Ligands
  • 3.1 Classification of ligands
  • 4. Receptors
  • 4.1 Classification of receptors
  • 4.2 Some of the examples of the receptors acting as therapeutic targets
  • 5. Conclusion
  • References
  • 2
  • Pharmacokinetics and pharmacodynamics
  • 1. Introduction
  • 1.1 Sources of drugs
  • 1.2 Drug nomenclature
  • 1.3 Drug classification
  • 1.4 Drug transport through cell membranes
  • 1.4.1 Simple diffusion
  • 1.4.2 Filtration
  • 1.4.3 Carrier mediated
  • 1.4.4 Endocytosis
  • 2. Pharmacokinetics (ADME)
  • 2.1 Absorption
  • 2.1.1 Bioavailability
  • 2.1.1.1 Factors affecting oral bioavailability
  • 2.1.2 Factors influencing digestive resorption
  • 2.1.2.1 Pharmaceutical form
  • 2.1.2.2 pH, PKa, log P, molecular weight
  • 2.1.2.3 Metabolism in the digestive tract, gastric secretion and food bowl
  • 2.1.2.4 First pass effect
  • 2.1.2.5 Other factors
  • 2.2 Distribution
  • 2.2.1 Patterns of distribution
  • 2.2.2 Factors affecting distribution of drugs
  • 2.2.3 Apparent volume of distribution (Vd)
  • 2.3 Metabolism (biotransformation)
  • 2.3.1 Site of metabolism
  • 2.3.2 Types of metabolic reactions
  • 2.3.3 Enzymes responsible for biotransformation
  • 2.3.4 Factors affecting hepatic microsomal enzyme activity
  • 2.4 Excretion
  • 2.4.1 Clearance
  • 2.5 Fundamental principles of pharmacokinetics
  • 2.5.1 Plasma half-life (t1/2)
  • 2.5.2 Loading dose
  • 2.5.3 Maintenance dose
  • 2.5.4 Methods used to prolong duration of action of drugs
  • 3. Pharmacodynamics
  • 3.1 Possible mechanisms of action of drugs
  • 3.2 Definition of receptors
  • 3.3 Affinity
  • 3.4 Efficacy
  • 3.5 Potency
  • 3.6 The amount of response
  • 3.7 Relation between concentration and response
  • 3.7.1 Dose-response curve of drugs
  • 3.7.2 Types of ligands
  • 3.7.3 Types of antagonists
  • 3.7.4 Non-competitive block types
  • 3.7.5 Types of receptors and signal transduction mechanism
  • 4. Conclusion
  • References
  • 3
  • Overview of drugs and drug targets
  • 1. Introduction
  • 1.1 Drug development process
  • 1.2 Discovery
  • 1.2.1 Target identification and validation
  • 1.2.2 Assay development
  • 1.2.3 Lead identification
  • 1.2.4 Lead optimization
  • 1.3 Development
  • 1.3.1 Predevelopment