Chromatin : structure, function, and history /
Brings the reader up to date on the remarkable progress made in chromatin research over the course of the past 50 years. Coverage includes the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin...
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| Format: | eBook |
| Language: | English |
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London : San Diego :
Academic Press,
[2024]
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Intro
- Chromatin: Structure, Function, and History
- Copyright
- Contents
- Preface
- Part 1: Chromatin structure
- Chapter 1: Early history
- 1869-1950: Identification of nucleic acid and the ``dark ages ́́of chromatin research
- Prelude to the nucleosome: 1950s and 1960s
- A model for the nucleosome: A new era of chromatin biology begins
- References
- Chapter 2: The nucleosome unveiled
- From model to structure: The nucleosome core particle
- Size and shape
- The path of the DNA
- Histones in the nucleosome
- The nucleosome unveiled: High-resolution structure of the core particle
- References
- Chapter 3: Chromatin compaction
- Early observations
- Factors influencing chromatin folding
- Cations
- Linker histones
- Histone tails
- The structure of compact chromatin
- Compact chromatin in living cells
- Chromosome architecture
- Chromosome territories
- Loops
- Topologically associating domains or TADs
- Liquid-liquid condensates
- Heterochromatin
- Heterochromatin in budding yeast
- References
- Chapter 4: Nucleosomes in context: Positioning, occupancy, and spacing
- Overview
- Rotational vs translational nucleosome positioning
- Nucleosome spacing
- Methods for determining nucleosome positioning
- Local analysis of nucleosome positioning
- Global analysis of nucleosome positioning
- First studies of nucleosome positioning
- Nucleosome positioning in vivo
- Heterogeneity in nucleosome positioning: Single cell approaches
- Mechanisms of nucleosome positioning
- Role of DNA sequence
- DNA bending and nucleosome positioning
- Poly(dA)-poly(dT) tracts and nucleosome exclusion
- Cis vs trans determinants of nucleosome positioning and occupancy
- Factors that contribute to nucleosome organization in trans
- Nucleosome-positioning proteins
- Nucleosome-excluding proteins
- Remodelers and nucleosome positioning
- Barrier elements, nucleosome spacing, and chromatin remodelers
- NDRs and ``fragile ́́nucleosomes
- References
- Chapter 5: Histones and variants
- General considerations
- Histone deposition and chromatin maturation following DNA replication
- Histone chaperones
- Histone variation: Early work
- Sea urchins: Variant histones expressed during development
- Other species
- Evolution of the histones
- Canonical histones: Nonallelic variants
- Histone mutants
- Specialized variants
- H2A.Z
- H2A.X
- H2A.B and the short H2A variants
- MacroH2A
- CenH3
- H3.3
- References
- Part 2: Chromatin function
- Chapter 6: Chromatin remodeling
- The SWI/SNF complex
- Yeast genetics points to a chromatin remodeling machine
- swi and sin mutants
- snf and ssn mutants
- spt mutants
- Connections between swi, snf, and spt mutants and chromatin
- The SWI/SNF complex as a chromatin remodeling machine
- More remodeling machines
- SWI/SNF in other species
- BAF mutations and cancer
- RSC: A close cousin of the SWI/SNF complex
- Chapter 7: Histone modifications
- Chapter 8: Chromatin and transcription.