Advancement of phenolic acids in drug discovery : fundamentals and applications /

This book explores the role of phenolic acids in drug discovery, focusing on their applications in medicine and biotechnology. Edited by Naresh Kumar, Nidhi Goel, and Jesus Simal Gandara, it provides a comprehensive overview of phenolic acids' biosynthesis, sources, and extraction methods. The...

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Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Format:	eBook
Language:	English
Published:	London : Academic Press, 2024.
Subjects:	Drugs. Phenolic acids. Pharmaceutical Preparations Médicaments. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Advancement of Phenolic Acids in Drug Discovery
Copyright Page
Contents
List of contributors
1 Phenolic acids: a brief overview*
1.1 Introduction
1.2 Biosynthesis and its regulation
1.3 Bioavailability and metabolism
1.4 Concluding remarks
Acknowledgments
References
2 Sources and extraction methods of phenolic acids
2.1 Introduction
2.2 Sources of phenolic acids
2.3 Classical and modern extraction methods
2.3.1 Classical methods
2.3.1.1 Maceration extraction
2.3.1.2 Decoction extraction
2.3.1.3 Soxhlet extraction
2.3.2 Modern extraction methods
2.3.2.1 Ultrasound-assisted extraction
2.3.2.2 Microwave-assisted extraction
2.3.2.3 Pressurized liquid extraction
2.4 Factors affecting the extraction
2.5 Current scenario and future trends
2.6 Concluding remarks
References
Further reading
3 Role of phenolic acids in plant system
3.1 Introduction
3.2 Phenolic compounds
3.3 Biosynthesis of phenolic acids
3.3.1 Shikimate/phenylpropanoid pathway
3.3.2 Phenylpropanoid pathway
3.4 Function of phenolic acids in plant system
3.4.1 Light stress
3.4.2 Temperature stress
3.4.3 Drought stress
3.4.4 Salinity stress
3.4.5 Microbial pathogens
3.4.6 Insects and herbivorous organisms
3.4.7 Plant growth and senescence
3.4.8 Pigments and aromatic compounds
3.4.9 Allelopathy
3.5 Conclusions
References
4A Antioxidant methods, in vitro and in vivo studies of phenolic acids
4A.1 Introduction
4A.2 Relationship between structure-antioxidant activities of phenolic acids
4A.2.1 Effect of the carboxylic acid group on antioxidant activity
4A.2.2 Effect of the methoxy and phenolic hydroxyl groups on antioxidant activity
4A.3 Commonly used methods for antioxidant potential of phenolic acids.
5.2 Mechanism of antimicrobial action of phenolic acids
5.3 Phenolic acids toward the advancement of antimicrobial drugs
5.3.1 Toward antibacterial and antifungal drugs development
5.3.2 Toward antiparasitic drugs development
5.3.3 Toward antiviral drugs development
5.4 Enhancing phenolic acids use in antimicrobial drug development
5.4.1 Combination therapy (phenolic acids and other compounds)
5.4.2 Phenolic acids in synergism with antibiotics
5.4.3 Phenolic acids for prevention of antimicrobial resistance
5.5 New technologies for antimicrobial agents' development
5.5.1 Nanotechnology
5.5.2 Computational and systems biology approach
5.5.3 Prodrugs revival and targeting Gram-negative bacteria mechanisms
5.5.4 Phenolic acid-metal complexing and green chemistry
5.5.5 Phenolic acid-biomaterials conjugates
5.6 Antimicrobial use of phenolic acids and phenolic acid-rich extracts in other industries
5.7 Major challenges to the use of phenolic acids in antimicrobial drug development
5.7.1 Potential side effects
5.7.2 Bioavailability concerns
5.7.3 Promising metabolites assessment methods
5.8 Future perspectives and concluding remarks
References
6 Promising role of phenolic acids as antimalarial and antiviral drugs
6.1 Introduction
6.2 Phenolic acids as potential antimalarial agents
6.3 Phenolic acids as potential antiviral agents
6.3.1 Class I: double-stranded DNA viruses
6.3.2 Class II: single-stranded DNA viruses
6.3.3 Class III: double-stranded RNA viruses
6.3.4 Class IV: positive-sense single-stranded RNA viruses
6.3.4.1 Family Picornaviridae
6.3.4.2 Family Caliciviridae
6.3.4.3 Family Flaviviridae
6.3.4.4 Family Togaviridae
6.3.4.5 Family Coronaviridae
6.3.5 Class V: negative-sense single-stranded RNA viruses
6.3.5.1 Family Rhabdoviridae.
6.3.5.2 Family Orthomyxoviridae
6.3.6 Class VI: single-stranded RNA viruses with a DNA intermediate
6.3.7 Class VII: double-stranded DNA viruses with a RNA intermediate
6.4 Conclusions
References
7 Development of phenolic acids-based system as anticancer drugs
7.1 Introduction
7.2 Occurrence and intake of phenolic acids
7.3 Phenolic acids as anticancer agents
7.4 Drug delivery systems with phenolic acids
7.4.1 Phenolic acid's encapsulation with polymers
7.4.1.1 In vitro studies
7.4.2 Nano-encapsulation of phenolic acids with natural nano-carriers
7.4.2.1 Nano-encapsulation technologies for phenolic acids based on specialized equipment
7.4.3 Use of phenolic acids as natural nano-carriers
7.4.3.1 In vitro studies
7.4.3.2 In vivo studies
7.5 Conclusion and future perspective
Acknowledgments
Conflicts of interest
References
8 Utility of phenolic acids in neurological disorders
8.1 Introduction
8.2 Phenolic acids action on nervous system population
8.2.1 Neuroprotective effects on neurons
8.2.2 Neuroprotective effects on glial cells
8.2.2.1 Effect on astrocytes
8.2.2.2 Effect on oligodendrocytes
8.2.2.3 Effect on microglial cells
8.3 Major activities of phenolic acids against neurological disorders
8.3.1 Phenolic acids as antidepressant agents
8.3.2 Phenolic acids as antiepileptic agents
8.3.3 Phenolic acids as memory improving agents
8.3.4 Phenolic acids as antiamnesic agents
8.3.5 Phenolic acids as antitauopathy agents
8.3.6 Phenolic acids as antitraumatic agents
8.3.7 Phenolic acids as regulators of psychotic disorders
8.3.8 Phenolic acids as cerebral antiischemic agents
8.4 Integration of phenolic acids in neuroprotective drugs development process
8.5 Major strategies to enhance bioefficacy of phenolic acids as neuroprotectants.