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Cancer therapy : potential applications of nanotechnology /

While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology with emphasis on polymeric nanoparticles in cancer therapy.

Bibliographic Details
Main Authors: Nimesh, Surendra (Author), Gupta, Nidhi (Author), Carneiro, Guilherme (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: Amsterdam, Netherlands : Elsevier, 2024.
Subjects:
Cancer > Treatment > Technological innovations.
Nanotechnology.
Nanotechnology
Nanotechnologie.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Cancer Therapy
  • Copyright Page
  • Dedication
  • Contents
  • List of contributors
  • About the authors
  • Foreword
  • Preface
  • 1 Introduction and barriers in cancer therapeutics
  • 1.1 Introduction
  • 1.2 Types of cancer
  • 1.3 Mechanism of cancer occurrence
  • 1.4 Treatment options available for cancer
  • 1.5 Limitations of present cancer treatment options
  • 1.6 Barriers encountered in cancer therapeutics
  • 1.7 Nanotechnology as an option for cancer therapeutics
  • References
  • 2 Nanoencapsulation approaches for enhancing cancer therapy
  • 2.1 Introduction
  • 2.2 Potentiality for the nanoencapsulation of anticancer agents
  • 2.2.1 Alterations in drug pharmacokinetic profile
  • 2.2.2 Drug protection
  • 2.3 Nanostructured drug delivery systems
  • 2.3.1 Nanocrystals
  • 2.3.2 Inorganic nanoparticles
  • 2.3.2.1 Metal oxide nanoparticles
  • 2.3.2.2 Metallic nanoparticles
  • 2.3.2.3 Magnetic nanoparticles
  • 2.3.2.4 Quantum dots
  • 2.3.3 Polymeric nanoparticles
  • 2.3.4 Lipid nanoparticles
  • 2.3.5 Liposomes
  • 2.3.6 Carbon nanotubes
  • 2.3.7 Dendrimers
  • 2.4 Nanotechnology application in cancer therapy
  • 2.4.1 Overcoming biological barriers
  • 2.4.2 Targeted delivery: enhanced permeability and retention effect (passive targeting) and active targeting
  • 2.4.3 Targeting the tumor heterogeneity
  • 2.4.4 Modulating the tumor microenvironment
  • 2.4.5 Disrupting cancer angiogenesis
  • 2.5 Current challenges of nanostructured drug delivery systems designing
  • 2.5.1 Cost of nanomedicine products
  • 2.5.2 Difficulties for scaling up nanomedicine products
  • 2.5.3 Protein corona effect
  • 2.5.4 Nanotoxicology
  • 2.5.5 Translation from preclinical to clinical studies
  • 2.6 Novel applications of nanotechnology in cancer
  • 2.6.1 Synergism between different drugs
  • 2.6.2 Immunotherapy
  • 2.6.3 Nucleic acid delivery
  • 2.7 Conclusion.
  • 7 Poly lactic-co-glycolic acid nanoparticles for anticancer therapy
  • 7.1 Introduction
  • 7.2 Chemical nature, synthesis, and characterization of poly lactic-co-glycolic acid
  • 7.2.1 Physicochemical properties of poly lactic-co-glycolic acid
  • 7.3 Advantages of poly lactic-co-glycolic acid as a nanoparticle for drug delivery
  • 7.4 Anticancer properties of poly lactic-co-glycolic acid nanoparticles
  • 7.5 Anticancer drugs delivered using poly lactic-co-glycolic acid nanoparticles
  • 7.5.1 Docetaxel
  • 7.5.2 Paclitaxel
  • 7.5.3 Etoposide
  • 7.5.4 Doxorubicin
  • 7.5.5 Trastuzumab
  • 7.5.6 Camptothecin
  • 7.5.7 Cisplatin
  • 7.5.8 Imatinib mesylate
  • 7.5.9 5-Fluorouracil
  • 7.5.10 Bortezomib
  • 7.5.11 Vincristine sulfate
  • 7.5.12 Methotrexate
  • 7.5.13 Lenalidomide
  • 7.5.14 Irinotecan
  • 7.5.15 Temozolomide
  • 7.5.16 Curcumin
  • 7.6 Mechanism(s) of the release of drugs from poly lactic-co-glycolic acid nanoparticles
  • 7.7 Poly lactic-co-glycolic acid along with other nanoparticles as anticancer agent
  • 7.7.1 Chitosan
  • 7.7.2 Liposome
  • 7.7.3 Dendrimer
  • 7.7.4 Iron oxide nanoparticles
  • 7.7.5 Gold nanoparticles
  • 7.7.6 Polyethylene glycol
  • 7.7.7 Carbon nanotube
  • 7.8 Toxicity associated with poly lactic-co-glycolic acid
  • 7.9 Conclusion
  • Future directions
  • References
  • 8 Dendrimers as anticancer delivery vectors
  • 8.1 Introduction
  • 8.2 Synthesis of dendrimers
  • 8.3 Classification of dendrimers
  • 8.4 Biomedical applications of dendrimers
  • 8.5 Antimicrobial agent
  • 8.6 Tissue engineering
  • 8.7 Transfection
  • 8.8 Drug delivery
  • 8.9 Dendrimers for cancer therapy
  • References
  • 9 Poly(lactic acid) (PLA) as drug and gene delivery system for tumor
  • 9.1 Introduction
  • 9.2 The importance of regulated drugs and gene delivery methods
  • 9.3 Overview of PLA as a biodegradable and biocompatible polymer.