Translational orthopedics /
| Corporate Author: | |
|---|---|
| Other Authors: | , , , , |
| Format: | eBook |
| Language: | English |
| Published: |
London, United Kingdom ; San Diego, CA :
Academic Press, an imprint of Elsevier,
[2024]
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| Series: | Handbook for designing and conducting translational research
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Translational Orthopedics
- Handbook for Designing and Conducting Clinical and Translational Research
- Translational Orthopedics
- Copyright
- Contents
- List of contributors
- Preface
- I
- Introduction
- 1
- Introduction
- Definitions and objectives
- Structure
- How to use this book
- Intervention development
- Clinical emphasis
- Limitations
- References
- 2
- Translational process
- Key points
- Introduction section/why it matters
- Translational research definition
- Historical perspective
- The process of translational research
- T0: Basic and applied research
- T1: Translation to humans
- T2: Translation to patients
- T3: Translation to practice
- T4: Translation to community
- Conclusion
- Get started
- Potential pitfalls
- Examples
- References
- 3
- Scientific method
- Key points
- Introductory section/Why it matters
- Text
- Observation
- Question
- Hypothesis
- Experiment
- Analysis
- Conclusion
- Get started
- Potential pitfalls
- Examples of scientific method
- Resources
- References
- 4
- Basic research
- Key points
- Why it matters
- Basic research and the "reductionist approach"
- Disciplines of basic research
- Get started
- References
- II
- Pre-clinical
- 5
- Overview of preclinical research
- Key points
- Introduction section/why it matters
- Get started
- Potential pitfalls
- Examples
- Resources
- References
- 6
- Formulating a researchable question: a critical step for facilitating good clinical research
- Key points
- Introduction
- Population
- Intervention
- Comparison
- Outcome
- Time frame
- Feasibility
- Interesting
- Novel
- Ethical
- Relevant
- Getting started
- Pitfalls to avoid
- Additional resources
- References
- 7
- Types of interventions: drug, device, diagnostic, procedural technique, or behavior change
- Key points
- Introduction
- Getting started
- Potential pitfalls
- Resources
- References
- 8
- Drug discovery
- Key points
- Why it matters?
- Drug discovery
- Small molecules
- Biological therapies
- Prodrugs
- The drug discovery process
- Target discovery
- Molecular diagnostics
- Antibodies
- Genetics
- Lead identification and lead optimization
- Disciplines and common lab methods and techniques
- Gel electrophoresis
- High-throughput screening
- Enzyme-linked immunosorbent assay
- Polymerase chain reaction
- Western blot
- Major areas of current investigation
- Osteoarthritis
- Chronic pain
- Three real-world examples of drug discovery
- Amyotrophic lateral sclerosis
- Osteoporosis
- Knee arthritis
- How to obtain funding and resources
- Get started with drug discovery
- Common mistakes and tips for drug discovery
- References
- 9
- Drug testing
- Key points
- "Why it matters?"
- Drug testing
- In vitro
- In vivo
- Harm
- Toxicity and dosing
- Good laboratory practice
- Get started
- Potential pitfalls