Ionotropic cross-linking of biopolymers : applications in drug delivery /

Ionotropic Cross-Linking of Biopolymers: Applications in Drug Delivery provides in-depth insights and presents the latest advances in ionotropic cross-linked biopolymeric systems for drug delivery and related applications.

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Other Authors:	Nayak, Amit Kumar, 1979-, Hasnain, Md Saquib, 1984-
Format:	eBook
Language:	English
Published:	Amsterdam : Elsevier, 2024.
Subjects:	Biopolymers. Drug delivery systems. Drug Delivery Systems. Alginates > therapeutic use. Drug Liberation. Ion Channels. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Ionotropic Cross-Linking of Biopolymers
Copyright Page
Contents
List of contributors
1 Introduction and fundamentals
1 Ionotropic cross-linking of biopolymers: basics and mechanisms
1.1 Introduction
1.2 Ionotropic gelation technique
1.3 Counter-ions (ionic cross-linkers) for ionotropic gelation
1.4 Some common ionic biopolymers and their ionotropic gelations
1.4.1 Alginates
1.4.2 Pectins
1.4.3 Gellan gum
1.4.4 Chitosan
1.4.5 Carrageenan
1.4.6 Dextran
1.4.7 Carboxymethyl polysaccharides
1.5 Formation of polyelectrolyte complexes via ionotropic gelations
1.6 Ionotropically gelled biopolymeric systems in drug delivery
1.7 Conclusion
References
2 Fundamentals and applications of ionic biopolymers
2.1 Introduction
2.2 Properties and advantages of ionic biopolymers
2.3 Challenges and limitations of ionic biopolymers
2.4 Preparation of Ionic Biopolymers
2.4.1 Polysaccharide/polysaccharide blends
2.4.2 Polysaccharide/polypeptide blends
2.4.3 Polysaccharide/bioplastic blends
2.5 Incorporation of pharmaceutical ingredients into biopolymer-based drug-delivery systems using ionic liquids
2.6 Strategies for assimilating pharmaceutical ingredients into biopolymer-based drug-delivery systems using ionic liquids
2.7 Electrospinning of biopolymer composites using ionic liquids
2.8 Enzyme-catalyzed processes in ionic liquids for biopolymer modification
References
3 Ionotropic cross-linking methods for different types of biopolymeric hydrogels
3.1 Introduction
3.2 Preparation of hydrogels
3.2.1 Chemical gelation
3.2.2 Physical gelation
3.2.2.1 Ionotropic gelation
3.2.2.2 Chitosan ionic gelation
3.2.2.2.1 Alginate gelation
3.2.2.2.2 Pectin
3.2.2.2.3 Biomedical application
3.3 Conclusion
References.
4 Ionotropic gelation in advanced drug delivery
4.1 Introduction
4.2 Biopolysaccharides
4.2.1 Definition
4.2.2 Properties
4.2.3 Composition
4.2.4 Classifications
4.2.4.1 By structure
4.2.4.1.1 Homopolysaccharides
4.2.4.1.2 Heteropolysaccharides
4.2.4.2 By source
4.2.4.3 By functions
4.3 Industrial applications of biopolysaccharides
4.4 Biomaterials-based hydrogels
4.4.1 Definition of hydrogel
4.4.2 Preparation techniques of hydrogels
4.4.3 Advantages of hydrogels
4.4.4 Hydrogels applications
4.5 Hydrogels based on biopolysaccharides and its potential application in drugs delivery
4.6 Conclusion
References
2 Ionotropically cross-linked biopolymers
5 Utilizing alginate-based delivery systems for anticancer therapeutics
5.1 Introduction
5.2 Alginate delivery systems
5.2.1 Alginate delivery systems used against colon cancer
5.2.2 Alginate delivery systems against breast and hepatic cancer
5.2.3 Alginate delivery systems used in various cell lines
5.3 Conclusion
References
6 Ionotropically crosslinked pectinate-based systems for drug delivery
6.1 Introduction
6.2 Pectin
6.2.1 Occurrence and structure
6.2.2 Physical and chemical behavior
6.2.3 Crosslinking of pectin
6.2.4 Factors affecting crosslinking
6.2.5 Types of crosslinking
6.2.5.1 Physical crosslinking
6.2.5.2 Chemical crosslinking
6.2.5.3 Ionotropic crosslinking
6.2.5.4 Miscellaneous crosslinking
6.2.6 Properties of crosslinked pectin (pectinate)
6.3 Applications of pectinate in drug delivery systems
6.3.1 pH-responsive drug delivery systems
6.3.2 Colon-specific targeting drug delivery systems
6.3.3 Floating drug delivery systems
6.3.4 Pulsatile drug delivery systems
6.3.5 Miscellaneous drug delivery systems
6.4 Current challenges and future prospects.
9.8.2 Swelling and charge density
9.8.3 Ionic cross-linkers
9.9 Ionotropical cross-linked carboxymethylated gums-based systems in drug delivery
9.9.1 Carboxymethylated xanthan gum
9.9.2 Carboxymethylated guar gum
9.9.3 Miscellaneous
9.10 Conclusion
References
10 Starches-blended ionotropically cross-linked biopolymeric matrices for sustained drug release
10.1 Introduction
10.1.1 Overview on starch
10.2 Ionotropic gelation of starch
10.3 Drug delivery applications
10.3.1 Rice starch
10.3.2 Jackfruit seed starch
10.3.3 Potato starch
10.3.4 Arrowroot
10.3.5 Cassava starch
10.3.6 Other starch
10.3.7 Modified starch
10.4 Other applications
10.5 Future remarks and conclusions
Acknowledgments
References
3 Ionotropically cross-linked biopolymeric systems
11 Ionotropically cross-linked polymeric nanoparticles for drug delivery
11.1 Introduction
11.2 Cross-linking technique for polymeric nanodrug delivery systems
11.2.1 Types of cross-linking technique
11.2.2 Hydrogel as cross-linked polymer
11.2.3 The importance of cross-linked polymeric nanoparticles for drug delivery
11.3 Ionotropic cross-linking technique
11.3.1 The mechanism of ionotropic cross-linking technique
11.3.2 Factors affecting preparation of ionotropically cross-linked polymeric nanoparticles
11.3.2.1 Effect of concentration
11.3.2.2 Effect of polyanion
11.3.2.3 Effect of surfactant
11.3.2.4 Effect of sonication
11.3.2.5 Temperature
11.3.2.6 pH of cross-linking solution
11.3.3 Ionotropic cross-linked polymeric nanoparticles
11.3.3.1 Chitosan
11.3.3.2 Alginate
11.3.3.3 Other polymeric species
11.4 Applications
11.5 Conclusion
References
12 Ionotropically cross-linked polymeric microparticles for drug delivery
12.1 Introduction.
12.2 Polymers in ionotropic gelation for drug delivery
12.2.1 Chitosan
12.2.2 Alginate
12.3 Methods of ionotropic gelation
12.4 Specific drug delivery applications of ionotropic-gelated microparticles
12.4.1 Controlled drug delivery
12.4.2 Targeted drug delivery
12.4.3 Vaccine delivery
12.4.4 Bioactive phytochemical compounds from plant
12.4.5 Encapsulation of probiotics
12.5 Evaluation of microparticles prepared by ionotropic gelation
12.5.1 Polymer-drug compatibility
12.5.1.1 Fourier transform infrared
12.5.1.2 Thermoanalytical methods
12.5.1.3 X-ray diffraction spectroscopy
12.5.2 Morphology
12.5.3 Zeta potential analysis
12.5.4 Porosity and density
12.5.5 Flow properties and compressibility index
12.5.6 Swelling index and erosion
12.5.7 Drug entrapment efficiency
12.5.8 Drug release study
12.5.8.1 Using dissolution test apparatus
12.5.8.2 Using container
12.5.8.3 Dialysis membrane method
12.5.9 Release mechanism
12.5.10 Mechanical strength of microparticles
12.6 Conclusion
Conflict of interest
References
13 Ionotropic cross-linked polymeric beads for drug delivery and in vitro applications
13.1 Introduction
13.2 Ionotropic polymers: basic mechanisms and processing techniques
13.2.1 Dripping method
13.2.2 Vibrating nozzle or laminar jet breakup
13.2.3 Mechanical cutting or jet cutter technology
13.2.4 Electrohydrodynamic atomization
13.3 Classification of ionotropic biopolymers
13.3.1 Alginate
13.3.2 Chitosan
13.3.3 Carboxymethyl cellulose
13.3.4 Gellan gum
13.4 Applications
13.4.1 Drug delivery
13.4.2 In vitro applications
Acknowledgments
References
14 Clay-reinforced ionotropically cross-linked biopolymeric matrices for drug release
14.1 Introduction.