Cellular, molecular, and environmental contribution in cardiac remodeling : from lab bench work to its clinical perspective /
Cellular, Molecular and Environmental Contribution in Cardiac Remodeling: From Lab Bench to Clinical Perspective consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucid...
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| Format: | eBook |
| Language: | English |
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London :
Academic Press,
2024.
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| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling
- Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling: From Lab Bench Work to Its Clinical Perspective
- Copyright
- Contents
- Preface
- 1
- Cardiac remodeling: Impacts on cardiac health and disease
- 1. Introduction
- 2. Physiological cardiac remodeling
- 3. Exercise-induced cardiac remodeling
- 4. Pregnancy-induced cardiac remodeling
- 5. Pathological cardiac remodeling
- 6. Hypertensive left ventricular remodeling
- 7. Atrophic cardiac remodeling
- 8. Ventricular remodeling in myocardial infarction
- 9. Metabolic remodeling of the heart
- 10. Diagnosis
- 11. Consequences
- 12. Congestive heart failure
- 13. Therapeutic targets
- 14. Fibrosis
- 15. Cardiomyocyte hypertrophy
- 16. Cardiomyocyte death
- 17. Vascular remodeling
- 18. Metabolic remodeling
- 19. Conclusion
- References
- 2
- Physiological cardiac modeling: Effects of exercise and other physical activities
- 1. Introduction
- 2. Effects of exercise and cardiovascular system
- 3. Effects of exercise on the cardiac remodeling
- 4. Effects of exercise on the left and right ventricles
- 5. Determinants of exercise-induced cardiac remodeling magnitude
- 6. Cellular and molecular mechanism of mechanisms of EICR
- 7. Energy metabolism, exercise, and cardiac remodeling
- 8. Cellular signaling system, exercise, and cardiac remodeling
- 9. Conclusions
- References
- 3
- Prognostic elements of unfavorable cardiac remodeling
- 1. Introduction
- 2. Left ventricular ejection fraction
- 3. Myocardial infarction
- 4. Ventricular dilatation
- 5. Wall thickness
- 6. Biomarkers
- 7. Hypertrophy
- 8. Fibrosis
- 9. Hemodynamic changes
- 10. Functional impairment
- 11. Symptom severity
- 12. Comorbidities
- 13. Response to treatment.
- 14. Summary
- References
- 4
- Neurohormones in cardiac remodeling and function
- 1. Introduction
- 2. Neurohormonal activation
- 3. The adrenergic nervous system in the heart
- 3.1 Adrenergic nervous system regulates cardiac inflammation
- 3.2 Adrenergic nervous system regulation in heart failure
- 3.3 Beta-adrenergic dysfunction on aging heart
- 3.4 Comparison between heart failure and aging heart
- 3.5 How safe to target the adrenergic nervous system to treat heart failure
- 4. RAAS perturbation
- 5. RAAS in cardiac remodeling
- 6. Conclusion
- References
- 5
- Cardiokines and cardiac remodeling
- 1. Introduction
- 2. The heart as an endocrine organ
- 3. Cardiokines in cardiac stress
- 4. Autocrine/paracrine signaling of cardiokines
- 5. Endocrine activities of cardiokines
- 6. Cardiokines as cardiac disorders biomarkers
- 7. Conclusion
- References
- 6
- Comparative effects of fatty acid and glucose in cardiac remodeling
- 1. Introduction
- 2. Cardiac hypertrophy impacting fatty acids and glucose metabolism
- 3. Glucose and cardiac remodeling
- 4. Fats and cardiac remodeling
- 5. Conclusions
- References
- 7
- Vitamins, minerals, and nutraceuticals: Their cardioprotective functions
- 1. Introduction
- 2. Cardiac protection by vitamins
- 3. Minerals and cardiac remodeling
- 4. Phenolic compounds and cardiac remodeling
- 5. Conclusions
- References
- 8
- Junctional adhesion molecules: Their roles in integrity and functionality of the heart
- 1. Introduction
- 2. Interactions and signaling pathways
- 3. Major functions
- 4. Role of junctional adhesion molecules in cardiovascular diseases
- 5. Conclusion and perspective
- References
- 9
- Composition and function of ion channels and their effects on cardiac remodeling
- 1. Introduction.
- 4. Regulation of myosin
- 5. Actin-myosin structural transition in heart diseases
- 6. Cardiac troponin: Biomarker of cardiac damage
- 7. Conclusion
- References
- 15
- Growth and proliferation of cardiomyocytes: Roles of energy metabolism, cell death, oxidative stress, and meta ...
- 1. Introduction
- 2. Microanatomy
- 3. Development of the heart
- 4. Cardiomyocyte cell cycle and regeneration potential
- 5. Cardiomyocyte senescence in adult heart
- 6. Cross-talk between cardiomyocytes and cardiac resident other cells during cardiac remodeling
- 7. Clinical perspective
- 8. Conclusion
- References
- 16
- Cardiac endothelial cells and their cross-talks with neighboring cells in cardiac remodeling
- 1. Introduction
- 2. Cardiac endothelial cell transcriptome
- 3. Functional significance of endothelial cells during cardiac remodeling
- 3.1 Mechanosensing and mechanoregulation
- 4. Maintenance of vascular tone
- 5. Hemostasis
- 6. Role in neovascularization
- 7. Act as conditional immune cells
- 8. Interaction with cardiomyocytes
- 9. Cross-talk with leukocytes
- 10. Differentiation into mesenchymal cells
- 11. Contribute to cardiac fibrosis
- 12. Recruitment of endothelial progenitor cells
- 13. Conclusion
- References
- 17
- Pathophysiology of cardiac fibroblasts and impacts on the severity of the cardiac disease
- 1. Cardiac fibroblasts
- 2. Cardiac-resident fibroblast activation
- 3. Origins and characterization of cardiac fibroblasts
- 4. Fibroblast responses to microenvironmental stimuli
- 5. Prime regulator of extracellular matrix turnover
- 6. Electrophysiology of cardiac fibroblasts
- 7. Contribution to cardiac fibrosis
- 8. Conclusion
- References
- 18
- Involvement of cardiac stem cells in cardiac remodeling or myocardial regeneration
- 1. Introduction
- 2. Self-renewal cells in the heart.
- 3. Embryological origin of cardiac stem cells
- 4. Endogenous cardiac stem and progenitor cells
- 5. The regenerative capacity of cardiac stem and progenitor cells
- 6. Metabolism of cardiac stem cells
- 7. Paracrine role of cardiac stem cells following cardiac injury
- 8. Cross-talk between cardiac stem cells and other cells
- 9. Clinical prospect
- References
- 19
- Cardiac pericytes and cardiac remodeling
- 1. Introduction
- 2. Properties of cardiac pericytes
- 3. Pericyte secretome
- 4. Contribution to cardiac homeostasis
- 5. Contribution to the cardiac remodeling process
- 6. Are cardiac pericytes and cardiac stem cells similar
- 7. Therapeutic potential of cardiac pericytes
- 8. Conclusion
- References
- 20
- Macrophages in the remodeling of diseased heart
- 1. Introduction
- 2. Identification of cardiac macrophages
- 3. Origin of cardiac macrophages
- 4. Role of macrophages during cardiac remodeling
- 5. Mechanism of macrophage polarization
- 6. Role of macrophages in ventricular arrhythmia
- 7. Conclusion
- References
- 21
- Inflammatory role of neutrophils in cardiac remodeling: Damage versus resolution
- 1. Introduction
- 2. Phenotypic heterogeneity of neutrophils
- 3. Contribution in adaptive immunity
- 4. Does circadian oscillation affect the neutrophil counts: Prognostic factor of disease outcome?
- 5. Dual role of neutrophil infiltration kinetics in cardiac remodeling: Damage versus resolution?
- 6. NETosis
- 7. Secreted extracellular vesicle-mediated effects in the heart
- 8. Provoking granulopoiesis during myocardial infarction
- 9. Production of specialized proresolving mediators
- 10. Angiogenic properties
- 11. Sexual dimorphism in postmyocardial infarction inflammatory responses
- 12. Conclusion
- References
- 22
- Extracellular vesicle in cardiac remodeling
- 1. Introduction.