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Cellular, molecular, and environmental contribution in cardiac remodeling
from lab bench work to its clinical perspective
Cellular, Molecular and Environmental Contribution in Cardiac Remodeling: From Lab Bench to Clinical Perspective consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucidating their mechanisms of action and the clinical.
Front Cover -- Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling -- Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling: From Lab Bench Work to Its Clinical Perspective -- Copyright -- Contents -- Preface -- 1 -- Cardiac remodeling: Impacts on cardiac health and disease -- 1. Introduction -- 2. Physiological cardiac remodeling -- 3. Exercise-induced cardiac remodeling -- 4. Pregnancy-induced cardiac remodeling -- 5. Pathological cardiac remodeling -- 6. Hypertensive left ventricular remodeling -- 7. Atrophic cardiac remodeling -- 8. Ventricular remodeling in myocardial infarction -- 9. Metabolic remodeling of the heart -- 10. Diagnosis -- 11. Consequences -- 12. Congestive heart failure -- 13. Therapeutic targets -- 14. Fibrosis -- 15. Cardiomyocyte hypertrophy -- 16. Cardiomyocyte death -- 17. Vascular remodeling -- 18. Metabolic remodeling -- 19. Conclusion -- References -- 2 -- Physiological cardiac modeling: Effects of exercise and other physical activities -- 1. Introduction -- 2. Effects of exercise and cardiovascular system -- 3. Effects of exercise on the cardiac remodeling -- 4. Effects of exercise on the left and right ventricles -- 5. Determinants of exercise-induced cardiac remodeling magnitude -- 6. Cellular and molecular mechanism of mechanisms of EICR -- 7. Energy metabolism, exercise, and cardiac remodeling -- 8. Cellular signaling system, exercise, and cardiac remodeling -- 9. Conclusions -- References -- 3 -- Prognostic elements of unfavorable cardiac remodeling -- 1. Introduction -- 2. Left ventricular ejection fraction -- 3. Myocardial infarction -- 4. Ventricular dilatation -- 5. Wall thickness -- 6. Biomarkers -- 7. Hypertrophy -- 8. Fibrosis -- 9. Hemodynamic changes -- 10. Functional impairment -- 11. Symptom severity -- 12. Comorbidities -- 13. Response to treatment.
14. Summary -- References -- 4 -- Neurohormones in cardiac remodeling and function -- 1. Introduction -- 2. Neurohormonal activation -- 3. The adrenergic nervous system in the heart -- 3.1 Adrenergic nervous system regulates cardiac inflammation -- 3.2 Adrenergic nervous system regulation in heart failure -- 3.3 Beta-adrenergic dysfunction on aging heart -- 3.4 Comparison between heart failure and aging heart -- 3.5 How safe to target the adrenergic nervous system to treat heart failure -- 4. RAAS perturbation -- 5. RAAS in cardiac remodeling -- 6. Conclusion -- References -- 5 -- Cardiokines and cardiac remodeling -- 1. Introduction -- 2. The heart as an endocrine organ -- 3. Cardiokines in cardiac stress -- 4. Autocrine/paracrine signaling of cardiokines -- 5. Endocrine activities of cardiokines -- 6. Cardiokines as cardiac disorders biomarkers -- 7. Conclusion -- References -- 6 -- Comparative effects of fatty acid and glucose in cardiac remodeling -- 1. Introduction -- 2. Cardiac hypertrophy impacting fatty acids and glucose metabolism -- 3. Glucose and cardiac remodeling -- 4. Fats and cardiac remodeling -- 5. Conclusions -- References -- 7 -- Vitamins, minerals, and nutraceuticals: Their cardioprotective functions -- 1. Introduction -- 2. Cardiac protection by vitamins -- 3. Minerals and cardiac remodeling -- 4. Phenolic compounds and cardiac remodeling -- 5. Conclusions -- References -- 8 -- Junctional adhesion molecules: Their roles in integrity and functionality of the heart -- 1. Introduction -- 2. Interactions and signaling pathways -- 3. Major functions -- 4. Role of junctional adhesion molecules in cardiovascular diseases -- 5. Conclusion and perspective -- References -- 9 -- Composition and function of ion channels and their effects on cardiac remodeling -- 1. Introduction.
4. Regulation of myosin -- 5. Actin-myosin structural transition in heart diseases -- 6. Cardiac troponin: Biomarker of cardiac damage -- 7. Conclusion -- References -- 15 -- Growth and proliferation of cardiomyocytes: Roles of energy metabolism, cell death, oxidative stress, and meta ... -- 1. Introduction -- 2. Microanatomy -- 3. Development of the heart -- 4. Cardiomyocyte cell cycle and regeneration potential -- 5. Cardiomyocyte senescence in adult heart -- 6. Cross-talk between cardiomyocytes and cardiac resident other cells during cardiac remodeling -- 7. Clinical perspective -- 8. Conclusion -- References -- 16 -- Cardiac endothelial cells and their cross-talks with neighboring cells in cardiac remodeling -- 1. Introduction -- 2. Cardiac endothelial cell transcriptome -- 3. Functional significance of endothelial cells during cardiac remodeling -- 3.1 Mechanosensing and mechanoregulation -- 4. Maintenance of vascular tone -- 5. Hemostasis -- 6. Role in neovascularization -- 7. Act as conditional immune cells -- 8. Interaction with cardiomyocytes -- 9. Cross-talk with leukocytes -- 10. Differentiation into mesenchymal cells -- 11. Contribute to cardiac fibrosis -- 12. Recruitment of endothelial progenitor cells -- 13. Conclusion -- References -- 17 -- Pathophysiology of cardiac fibroblasts and impacts on the severity of the cardiac disease -- 1. Cardiac fibroblasts -- 2. Cardiac-resident fibroblast activation -- 3. Origins and characterization of cardiac fibroblasts -- 4. Fibroblast responses to microenvironmental stimuli -- 5. Prime regulator of extracellular matrix turnover -- 6. Electrophysiology of cardiac fibroblasts -- 7. Contribution to cardiac fibrosis -- 8. Conclusion -- References -- 18 -- Involvement of cardiac stem cells in cardiac remodeling or myocardial regeneration -- 1. Introduction -- 2. Self-renewal cells in the heart.
3. Embryological origin of cardiac stem cells -- 4. Endogenous cardiac stem and progenitor cells -- 5. The regenerative capacity of cardiac stem and progenitor cells -- 6. Metabolism of cardiac stem cells -- 7. Paracrine role of cardiac stem cells following cardiac injury -- 8. Cross-talk between cardiac stem cells and other cells -- 9. Clinical prospect -- References -- 19 -- Cardiac pericytes and cardiac remodeling -- 1. Introduction -- 2. Properties of cardiac pericytes -- 3. Pericyte secretome -- 4. Contribution to cardiac homeostasis -- 5. Contribution to the cardiac remodeling process -- 6. Are cardiac pericytes and cardiac stem cells similar -- 7. Therapeutic potential of cardiac pericytes -- 8. Conclusion -- References -- 20 -- Macrophages in the remodeling of diseased heart -- 1. Introduction -- 2. Identification of cardiac macrophages -- 3. Origin of cardiac macrophages -- 4. Role of macrophages during cardiac remodeling -- 5. Mechanism of macrophage polarization -- 6. Role of macrophages in ventricular arrhythmia -- 7. Conclusion -- References -- 21 -- Inflammatory role of neutrophils in cardiac remodeling: Damage versus resolution -- 1. Introduction -- 2. Phenotypic heterogeneity of neutrophils -- 3. Contribution in adaptive immunity -- 4. Does circadian oscillation affect the neutrophil counts: Prognostic factor of disease outcome? -- 5. Dual role of neutrophil infiltration kinetics in cardiac remodeling: Damage versus resolution? -- 6. NETosis -- 7. Secreted extracellular vesicle-mediated effects in the heart -- 8. Provoking granulopoiesis during myocardial infarction -- 9. Production of specialized proresolving mediators -- 10. Angiogenic properties -- 11. Sexual dimorphism in postmyocardial infarction inflammatory responses -- 12. Conclusion -- References -- 22 -- Extracellular vesicle in cardiac remodeling -- 1. Introduction.