Fundmental principles of oxidative stress in metabolism and reproduction : prevention and management /
This book, edited by Faiza Alam and Rehana Rehman, delves into the fundamental principles of oxidative stress and its impact on metabolism and reproduction. It presents a comprehensive examination of oxidative stress, exploring its sources, mechanisms, and effects on various bodily functions and dis...
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| Format: | eBook |
| Language: | English |
| Published: |
[S.l.] :
Academic Press,
2024.
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| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Fundamental Principles of Oxidative Stress in Metabolism and Reproduction
- Fundamental Principles of Oxidative Stress in Metabolism and Reproduction: Prevention and Management
- Dedication
- Contents
- Contributors
- Preface
- Acknowledgments
- I
- Overview: Cause and mechanisms
- 1
- Introduction to oxidative stress
- Oxidative stress
- What is oxidative stress?
- Redox hypothesis
- Sources of ROS that influence the human body
- Exogenous sources/factors: These include changes in the environment that increase ROS production in cells such as (Antunes ...
- Endogenous sources/factors: Endogenous or intracellular factors include
- Influence of ROS on body functions
- OS and the defense of the human body
- What is an "antioxidant"?
- Types of antioxidants
- Antioxidants-Mechanism of protection
- Influence of oxidative stress: From health to disease
- OS and cardiovascular diseases
- Reactive species (ROS/RNS) and OS in joint problems
- OS and the brain
- OS and the eyes
- OS and the respiratory system
- OS and the skin
- OS and renal functions
- OS and gastrointestinal tract
- OS and the immune system
- OS and multiple organs
- Diagnosis: Biomarkers of OS
- Antioxidant defense and therapeutic implications
- Prevention
- References
- 2
- Role of free radicals in normal human physiology
- Overview of oxidative stress
- Free radicals
- Superoxide anion
- Hydrogen peroxide
- Hydroxyl radical
- Peroxyl radical
- Singlet oxygen radical
- Hypochlorous acid
- Nitrous oxide
- Enzymatic and nonenzymatic reactions of free radicals
- Free radicals, antioxidant, and tissue injuries
- Categories of defense mechanisms
- Oxidative stress and diabetes mellitus
- Techniques used for the identification of free radicals
- Oxidative stress and mitochondria
- Oxidative stress and inflammation.
- Oxidative stress and chronic inflammatory disorders
- Oxidative stress and infertility
- References
- 3
- Role of diet in the development of oxidative stress
- Introduction to oxidative stress
- Correlation between diet and oxidative stress
- Exercise and oxidative stress
- Scavenger-antioxidants
- Types of antioxidants
- Types of antioxidants
- Classification of antioxidants
- Classification of antioxidants
- Neutralizer of free radicals
- Antioxidants
- Antioxidants
- Cardioprotective eating
- Cardioprotective eating
- Phytonutrients
- Phytonutrients
- Antioxidant capacity measurement
- Nutritionally mediated oxidative stress
- Carbohydrates
- Carbohydrates
- Fats
- Fats
- Strategies for decreasing oxidative stress
- Strategies for decreasing oxidative stress
- Strategies to decrease oxidative stress
- Strategies to decrease oxidative stress
- Oxidative stress-induced diseases ameliorating by diet
- Oxidative stress-induced diseases ameliorating by diet
- Dietary concern
- Dietary concern
- Conclusion
- References
- 4
- Occupational hazards and oxidative stress
- Introduction
- Definition
- History
- Example at workplaces
- Mechanism of oxidative stress
- Formation of free radicals at the workplace
- Effects to the workers
- Cancer and oxidative stress
- Cardiovascular disease and oxidative stress
- Neurological disease and oxidative stress
- Respiratory disease and oxidative stress
- Rheumatoid arthritis and oxidative stress
- Kidney disease and oxidative stress
- Aging and oxidative stress
- Gastrointestinal tract and oxidative stress
- Reproduction and oxidative stress
- Prevention/management of occupational hazards and oxidative stress
- Conclusion
- References
- 5
- Role of radio-frequency electromagnetic waves in causing oxidative stress
- Introduction
- Material and methods.
- Electron microscopy
- RNA extraction
- Results
- Discussion
- Conclusion
- References
- 6
- Genetic variations and lifestyle in oxidative stress
- Introduction
- Importance of balancing oxidants and antioxidants
- Genetic variations and oxidative stress
- Role of genetics in the production and metabolism of ROS
- Effect of genetic variations on antioxidant enzymes
- Lifestyle factors and oxidative stress
- Diet and oxidative stress
- Physical activity and oxidative stress
- Environmental toxins and oxidative stress
- Interplay between genetic variations and lifestyle in oxidative stress
- Importance of considering both factors in assessing risk
- Conclusion
- Summary of the interaction between genetic variations and lifestyle in oxidative stress
- Importance of a holistic approach to understanding and managing oxidative stress
- References
- Further reading
- 7
- Aging: Generation of oxidative stress
- What is aging?
- Why it is important to know about the processes involved in aging?
- Overview of aging theories
- "Somatic mutation" theory
- Free radical theory/oxidative stress theory
- The cross-linking theory of aging
- Cell and role of organelles in ROS production
- Role of peroxisomes
- Role of endoplasmic reticulum
- Oxidative stress and age-related diseases
- How can we minimize OS?
- Polyphenols in honey
- Polyphenols in blueberries
- Polyphenols in green tea
- Polyphenols in red wine
- Dietary polyphenols in combating aging
- Summary
- References
- II
- Systemic effects of oxidative stress
- 8
- Oxidative stress and insulin resistance
- Introduction
- Insulin resistance
- Insulin and insulin signaling
- Pathophysiology of insulin resistance
- Etiology of insulin resistance
- Obesity
- Inflammation
- Mitochondrial dysfunction
- Aging
- Endoplasmic reticulum stress
- Oxidative stress.
- Mechanisms causing insulin resistance by oxidative stress
- Adipokine dysregulation
- NF-kB pathway
- JNK signaling pathway
- Symptoms of insulin resistance
- Complications of insulin resistance
- Role of antioxidants in insulin resistance
- Conclusion
- References
- 9
- Oxidative stress and cardiovascular diseases
- Background
- Free radicals involved in cardiovascular diseases
- Mechanism of redox signaling pathway
- What is the link between OS and cardiovascular disease? cause/association
- OS and pathogenesis of cardiovascular disease: The basic mechanism
- The role of endothelium and oxidative stress in cardiovascular disease
- Oxidative stress and hypertension
- Oxidative stress and myocardial damage
- Basis of cardiac failure and arrhythmias
- Oxidative stress and atherosclerosis
- The main contributor to ischemic heart disease
- Antioxidant therapy and drugs used to treat cardiovascular diseases due to oxidative stress
- Conclusion and future perspective
- References
- 10
- Oxidative stress and chronic kidney disease
- Background
- Introduction
- Reactive oxygen species
- Antioxidants
- Enzymatic antioxidants
- Water soluble antioxidants
- Dietary antioxidants
- Ascorbic acid
- Ascorbic acid
- Polyphenols-flavonoids
- Polyphenols-flavonoids
- Endogenous antioxidants
- Lipid-soluble antioxidants
- Trace elements
- Oxidative stress and chronic kidney disease
- Pathogenesis of oxidative stress in CKD
- Uremia and dialysis-related factors
- Diabetes and oxidative stress
- Dyslipidemia and oxidative stress
- Inflammation and oxidative stress
- Biomarkers of oxidative stress in CKD patients
- Clinical implications of oxidative stress in CKD patients
- Oxidative stress and CKD-mediated cardiovascular disease
- Atherosclerosis
- Anemia
- Amyloidosis
- Immunodeficiency.
- Protein-energy wasting syndrome
- Treatment
- N-acetylcysteine
- Vitamin E
- Vitamin C
- Omega-3 fatty acids
- Carnitine
- Coenzyme Q10
- Folic acid
- Trace elements
- Newer agents in modulating oxidative stress in CKD
- Conclusion
- References
- 11
- Oxidative stress in neurodegenerative diseases
- Alzheimer disease
- Treatment of Alzheimer's disease
- Parkinson's disease
- Treatment of Parkinson's disease
- Amyotrophic lateral sclerosis
- Treatment of amyotrophic lateral sclerosis
- References
- 12
- Oxidative stress, mechanisms of subfertility, and reproductive disorders in females
- Introduction
- Sources of ROS in the female reproductive system
- The role of reactive oxygen species in the normal functions of female reproductive organs
- Impact of oxidative stress on ovarian function
- Ovarian cycle
- Follicular phase
- Ovulatory phase
- Post ovulatory phase
- Corpus luteum formation
- Oxidative stress: Steroidogenesis
- The impact of OS on female reproductive health organs
- Effects on ovary
- Effects on oocyte
- Effects on uterus
- Effects on embryo
- Oxidative stress manifestations as a disease leading to infertility
- Polycystic ovary syndrome
- Endometriosis
- Preeclampsia
- Lifestyle: Oxidative stress and female infertility
- Conclusion and future directions
- References
- 13
- Oxidative stress, mechanisms, and subfertility in male
- Male subfertility
- Oxidative stress definition
- Sources of reactive oxygen stress
- Extrinsic
- Intrinsic
- Physiological role of reactive oxygen stress on spermatozoa
- Pathological effects of reactive oxygen stress on spermatozoa
- Oxidative-induced changes in conventional semen parameters
- Current approach for assessment of reactive oxygen stress markers in sperm and semen
- Direct assays
- Indirect assays.