Scale-up and chemical process for microbial production of plant-derived bioactive compounds : from laboratory to industry.
This book provides a comprehensive overview of the processes involved in the microbial production of plant-derived bioactive compounds, from laboratory research to commercial production. It covers various aspects of scale-up and chemical processes, including optimization of fermentation, metabolic e...
| Corporate Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
[S.l.] :
Academic Press,
2024.
|
| Series: | Developments in microbial cell factories
|
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover
- Scale-up and Chemical Process for Microbial Production of Plant-Derived Bioactive Compounds
- Copyright Page
- Contents
- List of contributors
- 1 Advances and prospects for advanced biomanufacturing
- Introduction
- Optimization and scale-up of fermentation process based on process parameter correlation analysis
- Key technologies and applications of optimization and scale-up of biological fermentation process based on process model
- Rational scale-up methodology combining cellular physiology and flow field of biochemical reactor
- Intelligent biomanufacturing is a strong driving force for the transformation and upgrading of bioeconomy
- Intelligent sensing of cell metabolism based on advanced online sensing technology
- Intelligent analysis of biological processes based on data science
- Intelligent manufacturing of industrial-scale bioprocess
- Acknowledgment
- References
- 2 Different microbial strategies used for industrial-scale production of plant-derived bioactive compounds
- Metabolic engineering facilitates de novo synthesis
- Typical steps
- Gene identification and characterization
- Suitable microbial host
- Introduction of target gene
- Optimization of target gene expression level
- Metabolic network modification
- Positive strains selection
- Scale-up fermentation
- Enzyme engineering for continuous biotransformation
- Enzyme engineering
- Identification of target enzyme with desired properties
- Mutant library generation
- High-throughput screening
- Processing technology
- Whole-cell catalysis
- Cell-free catalysis
- References
- 3 Optimization parameters for efficient scale-up of fermentation process
- Introduction
- Fermentation process characterization
- Process data acquiring, fusing, and visualization
- Laboratory scale-down tools for efficient and rational scale-up.
- Emerging trends and future directions
- References
- 4 Development of economic extraction and purification process for plant-derived bioactive compounds
- Introduction
- Separation and purification methods for bioactive compounds
- Solvent extraction method
- Microwave extraction method
- Adsorption separation technology
- Activated carbon adsorption separation technology
- Macroporous resin adsorption separation technology
- Foam separation technique
- Membrane separation technology
- Simulated moving bed chromatography
- Supercritical fluid extraction technology
- Existing problems and prospects
- Acknowledgment
- Declaration of interest
- References
- 5 Screening and characterization of probiotics for large-scale production of plant-derived prebiotics
- Methods for screening probiotics for plant fermentation
- Isolation of probiotics from plant-based foods and in vitro studies
- Whole-genome sequencing technologies
- Animal models
- Human clinical studies
- Generation of prebiotics from engineered microbes via plant biomass fermentation
- Grain fermentation to produce prebiotics
- Bean fermentation for prebiotic production
- Fruit and vegetable fermentation for prebiotic production
- Fermentation of other plants for prebiotic production
- Fermented tea
- Fermented feed
- Isolation of bioactive compounds
- Extraction of dietary fiber, polysaccharide, and oligosaccharide
- Physical methods
- Water extraction
- Microwave-assisted extraction
- Ultrasonic extraction
- Ultra-high-pressure extraction
- Chemical separation
- Enzyme separation
- Membrane separation
- Separation and extraction of functional peptides
- Macroporous resin adsorption chromatography
- Gel filtration chromatography
- Ion exchange chromatography
- Affinity chromatography
- Reversed-phase high-performance liquid chromatography (RP-HPLC).
- Separation and extraction of phenols
- Commercial production of plant-derived bioactive compounds
- Cereal-based production
- Vegetable- and fruit-based production
- Soy-based production
- Other plant-based materials
- Perspective
- Acknowledgments
- Declaration of interest
- References
- 6 Designing and engineering synthetic microbiota to utilize plant lignin-based biomass for the synthesis of bioactive compounds
- Introduction
- Upstream processing of lignin
- Lignin fractionation
- Depolymerization of lignin
- Acid/base-catalyzed depolymerization
- Oxidative depolymerization
- Reductive depolymerization
- Thermochemical transformation
- Photocatalytic depolymerization
- Bioprocessing
- Downstream bioprocessing of lignin
- Efficient utilization of lignin hydrolysate by lignin-degrading bacteria
- Transformation of platform compounds by lignin-degrading bacteria
- Biosynthesis of value-added aromatic compounds from platform compounds
- Biosynthesis of amines from platform compounds
- Biosynthesis of other refined compounds from platform compounds
- Conclusion and outlook
- Acknowledgments
- Author contributions
- Competing financial interests
- References
- 7 The principles to design and optimization of industrial bioprocesses
- Introduction
- Typical modes of bioprocess used in production
- Batch fermentation
- Continuous fermentation
- Fed-batch fermentation
- Design principles of the fermentation process
- Each fermentation type has its optimal application scenarios
- Basic principles for bioprocess design
- Strategies to improve performance of bioprocess
- Optimization of fermentation process based on online/offline parameters
- Optimization of fermentation processes based on predictions from machine learning
- Flow field optimization within bioreactors
- Changing the stirring method.
- Improving the flow field with baffles
- Simulation and optimization of the flow fluid within the fermenter
- Perspectives
- Acknowledgments
- Declaration of interests
- References
- 8 The synthetic probiotic microbiota and their potential applications in the production of plant-derived products
- Introduction
- Probiotics derived from fermented foods
- Synthetic probiotic microbiota
- Production of plant-derived products using synthetic probiotic microbiota
- Conclusions and perspectives
- Acknowledgments
- Declaration of interests
- References
- 9 Fermentation utilizing engineered microbes: revolutionizing the production of commercial products from plant-derived bioa...
- Abbreviations
- Introduction
- Commonly used engineered microorganisms for plant bioactive compound synthesis
- Escherichia coli
- Saccharomyces cerevisiae
- Advances in engineering metabolic pathways for plant bioactive compound synthesis
- Terpenoids
- Monoterpenoids
- Geraniol
- Linalool
- Sesquiterpenes
- Artemisinin
- Nerolidol
- Diterpenoids
- Triterpenoids
- Tetraterpenoids
- Alkaloids
- Monoterpene indole alkaloids
- Benzylisoquinoline alkaloids
- Flavonoids
- Flavanones
- Isoflavones
- Factors impacting the fermentation process of plant-derived bioactive compounds
- Strain engineering and optimization
- Carbon source
- Nitrogen source
- Incubation temperature
- Three main modes: batch, fed-batch, and continuous fermentation
- Batch mode
- Fed-batch mode
- Continuous mode
- Scaling up of industrial microbial fermentations
- Fermentation techniques: solid-state fermentation and submerged fermentation
- Solid-state fermentation
- Submerged fermentation
- Challenges ahead for the microbial synthesis of plant bioactive compounds
- Summary and future prospects
- References.