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Stem Cell in medicine /

Bibliographic Details
Main Authors: Higuchi, Akon, 1956- (Author), Zhou, Yinghong (Author), Chiou, Shih-Hwa (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: Cambridge, MA : Academic Press, an imprint of Elsevier, [2023]
Edition:First edition.
Series:Progress in molecular biology and translational science ; 199.
Subjects:
Stem cells.
Stem cells > Therapeutic use.
Stem Cells
Cellules souches.
Cellules souches > Emploi en thérapeutique.
Stem cells
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Intro
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Fundamental of hPSCs for medical
  • Chapter One: Introduction to stem cells
  • Abstract
  • 1 Introduction
  • 2 Fundamentals of stem cell research
  • 3 hPSCs
  • 4 Somatic cell reprogramming and induced pluripotent stem cells
  • 5 Adult stem cells
  • 6 Conclusion
  • Acknowledgment
  • References
  • Chapter Two: Engineered adult stem cells: Current clinical trials status of disease treatment
  • Abstract
  • 1 Introduction
  • 2 Cell source and applications of adult MSCs and HSCs
  • 3 Engineering techniques for adult MSCs and HSCs
  • 4 CRISPR/Cas9 system and strategies to overcome challenges
  • 5 Current clinical trial status of engineered MSCs, HSCs and EVs
  • 6 Future perspectives of personalised medicine using engineered stem cells
  • 7 Concluding remarks
  • References
  • Chapter Three: Xeno-free culture and proliferation of hPSCs on 2D biomaterials
  • Abstract
  • 1 Introduction
  • 2 Pluripotency assay of hPSCs
  • 3 Physical cues of cell culture materials direct the pluripotency and differentiation of hPSCs
  • 4 Two-dimensional (2D) cultivation of hPSCs on ECM-coated surfaces
  • 5 hPSC cultivation on peptide-immobilized surfaces
  • 6 hPSC cultivation on recombinant E-cadherin matrices
  • 7 hPSC cultivation on polysaccharide-immobilized biomaterials
  • 8 hPSC cultivation on a synthetic polymer surface
  • 9 Conclusion and future perspectives
  • Acknowledgments
  • References
  • Chapter Four: Stem cell culture and differentiation in 3-D scaffolds
  • Abstract
  • 1 Introduction
  • 2 The 3-D cultivation of hPS cells on microcarriers
  • 3 The 3-D culture of hPS cells entrapped in hydrogels (microcapsules)
  • 4 Differentiation of hPS cells into hepatocytes on 3-D cultivation
  • 5 Conclusion and future perspectives
  • Acknowledgments
  • References
  • Clinical application.
  • Chapter Five: Current trends and promising clinical utility of IPSC-derived MSC (iMSC)
  • Abstract
  • 1 Introduction
  • 2 Generation of iMSCs from iPSC
  • 3 General characteristics of iMSC in comparison to primary MSC
  • 4 Properties of iMSC that may cater to large scale production of homogenous clinical grade MSCs
  • 5 Applications of iMSC
  • 6 Scaling up
  • 7 Conclusion
  • References
  • Chapter Six: Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells
  • Abstract
  • 1 Introduction
  • 2 Materials and methods
  • 3 Results
  • 4 Discussion
  • 5 Ethics approval and consent to participate
  • References
  • Chapter Seven: Cardiac cell sheet engineering for regenerative medicine and tissue modeling
  • Abstract
  • 1 Introduction
  • 2 Cell sheet engineering
  • 3 Development of human cardiac tissue for regenerative medicine
  • 4 Tissue function evaluation technologies
  • 5 For the improvement of human cardiac tissue function
  • 6 Tissue models for disease research
  • Acknowledgment
  • References
  • Chapter Eight: Mesenchymal stem cells in osteoarthritis: The need for translation into clinical therapy
  • Abstract
  • Abbreviations
  • 1 Properties of MSCs for regenerative medicine
  • 2 Functional effects of mesenchymal stem cells on OA
  • 3 MSCs therapy for human osteoarthritis
  • 4 MSCs therapy for OA in small animal model
  • 5 MSCs therapy for OA in large animal model
  • 6 Mechanisms of action of mesenchymal stem cells in cartilage repair
  • 7 MSCs derived factors in cartilage repair
  • 8 MSCs derived extracellular vesicles in cartilage repair
  • 9 Future, challenges and controversies
  • References
  • Chapter Nine: hPSC-derived RPE transplantation for the treatment of macular degeneration
  • Abstract
  • 1 Introduction
  • 2 Differentiation methods of hPSC-derived RPE
  • 3 Characterization of hPSC-derived RPE.
  • 4 Clinical outcomes of hPSC-derived RPE transplantation
  • 5 Conclusion and future perspective
  • Acknowledgment
  • References
  • Chapter Ten: Universal and hypoimmunogenic pluripotent stem cells for clinical usage
  • Abstract
  • 1 Introduction
  • 2 Preparation of universal (hypoimmunogenic) hPS cells
  • 3 Preparation of universal hPS cells using B2MG knockout
  • 4 Preparation of universal hPS cells by knocking down or knocking out HLA-A, -B, and/or -C
  • 5 Preparation of HLA-homozygous cells by genome editing techniques
  • 6 Universal hPS cell generation by knocking in several specific genes
  • 7 Universal hPSC generation from particular MSCs with immunomodulatory potential and culturing on specific extracellular matrix
  • 8 Universal hPS cell generation without gene modification
  • 9 Conclusion and future perspectives
  • Acknowledgment
  • References
  • Chapter Eleven: Clinical usage of dental stem cells and their derived extracellular vesicles
  • Abstract
  • 1 Introduction
  • 2 Stem cells of dental origin
  • 3 Preclinical and clinical applications of DSCs
  • 4 DSC-derived EVs and their clinical implications
  • 5 Conclusive remarks and future perspective
  • References
  • Chapter Twelve: Vascularization of cutaneous wounds by stem cells
  • Abstract
  • 1 Introduction
  • 2 Endothelial progenitor cells
  • 3 Induced pluripotent stem cells
  • 4 Mesenchymal stem/stromal cells
  • 5 Conclusions
  • References
  • Chapter Thirteen: Application of IPSC and Müller glia derivatives in retinal degenerative diseases
  • Abstract
  • 1 Regeneration of Müller glial cells
  • 2 Transplanted Müller glial cells promote neuronal repair
  • 3 Proliferation and reprogramming of Müller glial cells promoted by exogenous stem cell transplantation can be used for the experimental treatment of retinal nerve regeneration.
  • 4 Transplantation of Müller glial cell-derived neurons in an animal model of retinal degeneration
  • 5 The application of human pluripotent stem cells and Müller glial cells in the treatment of glaucoma
  • 6 The application of human pluripotent stem cells and Müller glial cells in the treatment of retinitis pigmentosa
  • References
  • Chapter Fourteen: Pluripotent stem cells as a therapy for type 1 diabetes
  • Abstract
  • 1 Current status of T1D
  • 2 Pancreatic islet therapy is a good alternative to subcutaneous insulin administration
  • 3 Pluripotent stem cell derived islets are a potential alternative to pancreatic islets
  • 4 Clinical trials with stem cell derived ß cell precursors
  • 5 Clinical trial with stem cell derived beta cells
  • 6 Immunoisolatory devices to prevent allograft and autoimmune rejection
  • 7 Conclusion
  • References
  • Chapter Fifteen: Stem cell challenges and opportunities
  • Abstract
  • 1 Introduction
  • 2 Materials and methods
  • 3 Results
  • 4 Discussion
  • Acknowledgments
  • References
  • Index.