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Heart development and disease /

Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Dubois, Nicole (Editor)
Format: eBook
Language:English
Published: London : Academic Press, an imprint of Elsevier, 2024
Edition:First edition.
Series:Current topics in developmental biology ; v. 156.
Subjects:
Heart > Growth.
Heart > Diseases.
Cœur > Croissance.
Cœur > Maladies.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Series Page
  • Title Page
  • Copyright
  • Contents
  • Contributors
  • Preface: Pushing the boundaries of cardiovascular research through interdisciplinary approaches, innovative thinking and new technologies
  • Chapter One: Macrophage lineages in heart development and regeneration
  • 1 Introduction
  • 2 Macrophage lineage transitions in the developing heart
  • 3 Contributions of macrophage lineages to cardiac organogenesis
  • 3.1 Valve remodeling and maturation
  • 3.2 Coronary and lymphatic vessel development
  • 3.3 Conduction system maturation and function
  • 4 Macrophages in cardiomyocyte maturation and heart regeneration after birth
  • 5 Summary and conclusions
  • Acknowledgements
  • References
  • Chapter Two: Computational approaches for mechanobiology in cardiovascular development and diseases
  • 1 Introduction
  • 2 Fundamental concepts in computational cardiovascular modeling
  • 3 Computational modeling to investigate mechanobiology in cardiac development
  • 4 Computational hemodynamic modeling for treatment planning in congenital heart
  • 5 Computational predictive modeling of tissue growth and remodeling
  • 6 Challenges and future opportunities
  • References
  • Chapter Three: RNA binding proteins in cardiovascular development and disease
  • 1 RNA binding proteins
  • 2 Role of RBPs in mRNA life cycle
  • 2.1 5' capping
  • 2.2 3' cleavage and polyadenylation and alternative polyadenylation
  • 2.3 RNA modifications/RNA editing
  • 2.4 Pre-mRNA splicing and alternative splicing
  • 2.5 mRNA transport and localization
  • 2.6 mRNA stability amp
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  • degradation
  • 2.7 mRNA translation
  • 3 RNA binding protein-RNA complexes
  • 4 RBPs in heart development
  • 5 RBPs in congenital heart defects
  • 6 Septation defects with RBP involvement
  • 6.1 Atrial septal defect
  • 6.2 Ventricular septal defect.
  • 6.3 Atrioventricular septal defect
  • 6.4 Persistent truncus arteriosus
  • 7 Outflow track/blood vessel/valve related congenital heart defects with RBP involvement
  • 7.1 Left coronary artery fistula
  • 7.2 Patent ductus arteriosus
  • 7.3 Pulmonary stenosis
  • 7.4 Valve defects
  • 8 Other congenital heart defects with RBP involvement
  • 8.1 Double outlet right ventricle
  • 8.2 Double outlet left ventricle
  • 8.3 Double inlet left ventricle
  • 9 Cardiomyopathy/heart failure with RBP involvement
  • 10 Dilated cardiomyopathy
  • 10.1 Hypertrophic cardiomyopathy
  • 10.2 Arrhythmogenic cardiomyopathy
  • 10.3 Non-compaction cardiomyopathy
  • 11 Complex congenital diseases with RBP involvement
  • 11.1 Hypoplastic left heart syndrome
  • 11.2 Tetralogy of fallot
  • 11.3 TARP syndrome
  • 11.4 Singleton-Morten syndrome
  • 12 RBPs in congenital heart diseases
  • 13 RBFOX2/RBM9 and RBFOX1/A2BP1 (RNA binding Fox-1 homolog 1 amp
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  • 14 GATA4 (GATA binding protein 4)
  • 15 DiGeorge syndrome critical region 8 (DGCR8)/Pasha
  • 16 CPSF6: cleavage and polyadenylation specific factor 6 (CFlm68 or CPSF68)
  • 17 NONO/ Non-POU domain containing octamer binding
  • 18 RBM20/ RNA binding motif protein 20
  • 19 RBM10/RNA binding motif protein 10
  • 20 hnRNPA1/heterogeneous nuclear ribonucleoprotein A1
  • 21 DDX3X/ DEAD-box helicase 3 X-linked
  • 22 ADAR/adenosine deaminase RNA specific
  • 23 hnRNPU/heterogeneous nuclear ribonucleoprotein U/scaffold attachment factor A (SAF-A)
  • 24 PUF60/Poly(U) binding splicing factor 60
  • 25 LRPPRC/leucine rich pentatricopeptide repeat containing/leucine-rich PPR motif-containing protein, mitochondrial
  • 26 RBM8A (RNA binding motif protein 8A)
  • 27 Ribosomal proteins
  • 28 RPL3L/ribosomal protein L3 like
  • 29 RBPs associated with congenital heart defects in animal models.
  • 29.1 PABPC1/ Poly(A) binding protein cytoplasmic1/PABPN
  • 30 QKI/quaking
  • 31 PCBP1/poly(RC) binding protein1/ hnRNPE1/heterogeneous nuclear ribonucleoprotein E1
  • 32 RBPs involved in heart development
  • 32.1 RBPMS1 and RBPMS2/ RNA binding protein with multiple splicing 2
  • 33 Polypyrimidine tract binding protein 1
  • 34 RNA binding motif protein 15
  • 35 Concluding remarks
  • Acknowledgements
  • Declaration of interests
  • References
  • Chapter Four: Cardiac construction-Recent advances in morphological and transcriptional modeling of early heart development
  • 1 Introduction
  • 2 Early heart development: specification, differentiation and assembly
  • 2.1 Dissecting spatiotemporal specification of cardiac progenitors
  • 2.2 Integrating differentiation and morphogenesis to construct the heart tube
  • 2.3 Working together-how tissue interactions help build the heart
  • 2.4 Processes underlying tube assembly help promote early looping morphogenesis
  • 3 Feel the beat: the intersection of form and function in the early heart
  • 3.1 Onset of cardiac contractility coincides with early heart morphogenesis
  • 3.2 Cross-talk between cardiac function, morphology and differentiation in the early heart
  • 4 Stem cells, organoids, and cardioids: in vitro technologies to investigate early heart development
  • 5 Challenges and future perspectives
  • Acknowledgments
  • References
  • Chapter Five: The cardiac conduction system: History, development, and disease
  • 1 Introduction
  • 2 History of the CCS: Discovery and nomenclature
  • 2.1 Jan Evangelista Purkinje: Discovery of Purkinje fibers
  • 2.2 Walter Gaskell: Myogenic theory and understanding AV conduction
  • 2.3 Wilhelm His Jr.: Discovery of the AV bundle
  • 2.4 Sunao Tawara: Discovery of the AVN and the "Reizleitungssystem" model
  • 2.5 Sir Arthur Keith and Martin Flack: Discovery of the SAN.
  • 5.2 Transcription factors controlling differentiation and maturation
  • 5.3 Development and differentiation pathways
  • 5.4 Metabolism and oxidative stress response genes
  • 5.5 Sarcomere, structural, and scaffold encoding genes
  • 6 Ploidy and basal heart function or other non-injury phenotypes
  • 6.1 Increased polyploidy coincides with ventricular dimension phenotypes
  • 6.2 Conduction
  • 7 Ploidy and injury response
  • 7.1 Individual gene manipulation and the injury response
  • 7.2 Genetic interaction enhancements
  • 7.3 Ploidy and transient improvement
  • 7.4 No observed improvement
  • 7.5 Genetic changes to regenerative-competent models
  • 8 Conclusions
  • Acknowledgements
  • References
  • Chapter Eight: Genetics and etiology of congenital heart disease
  • 1 Introduction: genetic etiologies of congenital heart disease
  • 2 Aneuploidies
  • 2.1 Fly (Drosophila melanogaster)
  • 2.2 Zebrafish (Danio rerio)
  • 2.3 Mouse (Mus musculus)
  • 2.4 Human data
  • 3 Structural variants
  • 3.1 Fly models
  • 3.2 Human data
  • 4 Single gene variants
  • 4.1 Mendelian inheritance
  • 4.1.1 Fly models
  • 4.2 Zebrafish models
  • 4.3 Mouse models
  • 4.4 Human studies
  • 4.4.1 De novo variants
  • 4.5 Animal models
  • 4.6 Human studies
  • 4.7 Mosaicism
  • 5 Noncoding variants: common, rare, and de novo CHD risk
  • 6 Conclusions
  • References
  • Back Cover.