Exosomal RNA : role in human diseases and therapy /

Bibliographic Details
Corporate Author:	ScienceDirect (Online service)
Format:	eBook
Language:	English
Published:	[S.l.] : Academic Press, 2024.
Subjects:	RNA. Exosome Multienzyme Ribonuclease Complex Neoplasms RNA ARN. Electronic books.
Online Access:	Connect to the full text of this electronic book

Table of Contents:

Front Cover
Exosomal RNA
Exosomal RNA: ROLE IN HUMAN DISEASES AND THERAPY
Contents
Contributors
Preface
One
Exosomal RNA-an introduction
1 Introduction
2 Characteristics of exosomal RNA
2.1 Exosomal MiRNAs
2.2 Exosomal circular RNAs
3 Importance of exosomal RNAs
4 Role of exosomal RNAs in different diseases
4.1 Cancer diagnosis and prognosis
4.2 Autophagy-related disorder
4.3 Diabetic and metabolic diseases
4.4 Immunological diseases
4.5 Neurodegenerative diseases
4.6 Aging-related disorder
4.7 Cardiovascular diseases
4.8 Renal disease [81]
4.9 Bacterial infection diseases
4.10 Wound healing and tissue repairing
5 Concluding remarks
References
Two
Biogenesis of exosome and exosomal RNA and its isolation and physical characterizations
1 Introduction
1.1 Biogenesis and release of exosomes
1.2 Endosomal sorting complex required for transport and exosomal biogenesis
1.3 ESCRT-independent mechanism of exosome biogenesis
1.4 MVBs transport to the membrane and release exosomes
1.5 Basal composition and cargo
1.5.1 Nucleic acids
1.5.2 Proteins
1.5.3 Lipids
2 Exosome isolation
2.1 Ultrafiltration
2.2 Ultracentrifugation
2.2.1 Differential ultracentrifugation
2.2.2 Density gradient ultracentrifugation
2.3 Precipitation
2.4 Immunoaffinity capture
2.5 Size-exclusion chromatography
3 Characterization of exosomes
3.1 Ultrastructural analysis
3.2 Nanoparticle tracking analysis
3.2.1 Advantages of NTA
3.2.2 Disadvantages of NTA
3.3 Atomic force microscopy
3.4 Flow cytometry
3.5 Western blotting
3.6 Other methods
3.6.1 Fluid flow fraction
3.6.2 Raman spectroscopy
4 Conclusion
References
Three
Exosomal RNA in cancer progression
1 Introduction
2 Exosomal RNAs in cancer progression
2.1 Gastrointestinal cancer progression
2.1.1 Gastric cancer progression
2.1.2 Pancreatic cancer progression
2.1.3 Hepatocellular carcinoma progression
2.1.4 Colorectal cancer progression
2.2 Blood cancer progression
2.3 Lung cancer progression
2.4 Breast cancer progression
2.5 Glioma progression
2.6 Thyroid cancer progression
2.7 Cervical cancer progression
2.8 Prostate cancer progression
2.9 Ovarian cancer progression
3 Conclusion
References
Further reading
Four
Exosomal RNA as a biomarker in cancer diagnostics and therapy
1 Introduction
2 Exosomal RNA as a biomarker for diagnosis and therapy outcome of common tumor types
2.1 Brain cancer
2.2 Oral cancer
2.3 Breast cancer
2.4 Lung cancer
2.5 Skin cancer
2.6 Liver cancer
2.7 Gastric cancer
2.8 Pancreatic cancer
2.9 Prostate cancer
2.10 Gynecological cancers
2.11 Colorectal cancer
2.12 Hematological cancers
3 Conclusion
References
Five
Exosomal RNA and autophagy
1 Introduction
2 Exosome biogenesis and composition