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Molecular biology of B cells.

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Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production.These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of c...

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Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Honjo, T. (Tasuku), 1942- (Editor), Reth, Michael (Editor), Radbruch, A. (Andreas) (Editor), Alt, Frederick W. (Editor), Martin, Alberto (Editor)
Format: eBook
Language:English
Published: Amsterdam : Academic Press, 2024.
Edition:Third edition. /
Subjects:
Molecular immunology.
B cells.
Immunoglobulins.
Immunoglobulin genes.
Immunologie moléculaire.
Lymphocytes B.
Gènes de l'immunoglobuline.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Molecular Biology of B Cells
  • Molecular Biology of B Cells
  • Copyright
  • Contents
  • Contributors
  • Preface
  • 1
  • The Structure and Regulation of the Immunoglobulin Loci
  • 1. INTRODUCTION
  • 2. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
  • 3. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS
  • 4. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS
  • 5. B CELL DEVELOPMENT AND REGULATION OF V(D)J RECOMBINATION
  • 6. JUNCTIONAL DIVERSITY
  • 7. COMBINATORIAL DIVERSITY
  • 8. NONCODING TRANSCRIPTION AND IMMUNOGLOBULIN LOCUS REARRANGEMENT
  • 9. THE PROCESS OF DH-JH RECOMBINATION
  • 10. EPIGENETICS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT
  • 11. INSULATORS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT
  • 12. 3D STRUCTURE AND COMPACTION OF THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
  • 13. CONCLUSION
  • References
  • 2
  • The Mechanism, Regulation and Evolution of V(D)J Recombination
  • 1. INTRODUCTION
  • 2. RAG 1/2 ACTIVITY IN V(D)J RECOMBINATION
  • 2.1 Overview
  • 2.2 Antigen Receptor Gene Assembly
  • 2.3 Recombination Signal Sequences
  • 2.4 Biochemistry of RAG-Mediated DNA Cleavage
  • 2.5 RAG1 and RAG2
  • 2.6 HMGB1 and HMGB2 in V(D)J Recombination
  • 2.7 The Structure of RAG-RSS Complexes and the Mechanism of the 12/23 Rule
  • 2.8 Structural Insights into the Mechanism of DNA Cleavage by RAG
  • 3. THE JOINING PHASE OF V(D)J RECOMBINATION
  • 3.1 Overview: V(D)J Joining Employs the Non-Homologous End Joining Pathway of DSB Repair Pathway
  • 3.2 Evolutionarily Conserved Core C-NHEJ Factors (KU70, KU80, XRCC4 and Ligase 4)
  • 3.3 Non-Evolutionarily Conserved C-NHEJ Factors with Specialised Functions: DNA-PKcs and Artemis
  • 3.4 Diversification of Antigen Receptor Repertoires by C-NHEJ Activities
  • 3.5 Impact of Defects in C-NHEJ Factors on Lymphocyte Development and Cancer.