http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Molecular Biology of B Cells, Third Edition is a comprehensive reference to how B cells are generated, selected, activated, and engaged in antibody production.These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.
Front Cover -- Molecular Biology of B Cells -- Molecular Biology of B Cells -- Copyright -- Contents -- Contributors -- Preface -- 1 -- The Structure and Regulation of the Immunoglobulin Loci -- 1. INTRODUCTION -- 2. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN HEAVY CHAIN LOCUS -- 3. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS -- 4. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS -- 5. B CELL DEVELOPMENT AND REGULATION OF V(D)J RECOMBINATION -- 6. JUNCTIONAL DIVERSITY -- 7. COMBINATORIAL DIVERSITY -- 8. NONCODING TRANSCRIPTION AND IMMUNOGLOBULIN LOCUS REARRANGEMENT -- 9. THE PROCESS OF DH-JH RECOMBINATION -- 10. EPIGENETICS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT -- 11. INSULATORS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT -- 12. 3D STRUCTURE AND COMPACTION OF THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS -- 13. CONCLUSION -- References -- 2 -- The Mechanism, Regulation and Evolution of V(D)J Recombination -- 1. INTRODUCTION -- 2. RAG 1/2 ACTIVITY IN V(D)J RECOMBINATION -- 2.1 Overview -- 2.2 Antigen Receptor Gene Assembly -- 2.3 Recombination Signal Sequences -- 2.4 Biochemistry of RAG-Mediated DNA Cleavage -- 2.5 RAG1 and RAG2 -- 2.6 HMGB1 and HMGB2 in V(D)J Recombination -- 2.7 The Structure of RAG-RSS Complexes and the Mechanism of the 12/23 Rule -- 2.8 Structural Insights into the Mechanism of DNA Cleavage by RAG -- 3. THE JOINING PHASE OF V(D)J RECOMBINATION -- 3.1 Overview: V(D)J Joining Employs the Non-Homologous End Joining Pathway of DSB Repair Pathway -- 3.2 Evolutionarily Conserved Core C-NHEJ Factors (KU70, KU80, XRCC4 and Ligase 4) -- 3.3 Non-Evolutionarily Conserved C-NHEJ Factors with Specialised Functions: DNA-PKcs and Artemis -- 3.4 Diversification of Antigen Receptor Repertoires by C-NHEJ Activities -- 3.5 Impact of Defects in C-NHEJ Factors on Lymphocyte Development and Cancer.